Hoʻokolohua-blockers

Hoʻokolohua-blockers i hoʻohana like antihypertensive ai ' mai ka kakahiaka nui sixties. No ka mea, ua pono hoʻopaʻa pepa paʻi kiʻi i ka ka loaʻaʻana o nā hopena mua o ka lapaau a me ka la o ko lākou laulā ma lehulehu kekahi lāʻau 'haʻawina, e like me ka e like me ka hopena o ka nui kēiaʻano.

Hoʻokolohua-blockers e hoʻohana ana i lalo ke koko, a me ka pale aku i ka ulu ana o ka mea'ōnaehana mānowai koko mai a me ka make. Keʻano papa hana o ko lākou antihypertensive ana ua ma muli o ka ka ho'ēmiʻana i loko o cardiac auoiaea ku i ka ka ho'ēmiʻana o ka ikaika a me ka alapine (frequency) o contractions. Eia hou kekahi, Hoʻokolohua-blockers he hoʻonui i ka suppression o secretion o renin i loko o ka juxtaglomerular (okoloklubochkovom) hakuʻala i hoʻomākaukauʻia, a ma keia manao, i ka pono uhi i ka ha awina o ka renin-angiotenzinaldosteronovoy a kikowaena vasomotor nenoai.

Lākou hooloihi ae i pono ai ke hoʻonāukiuki i ka emi ana o vascular ia'ku (huinaʻike ākea), ma muli o ka mahuahua baroreceptor pā lonoaʻili, a? Iecaianoaaiiuo i loko o ka pā o ka vascular prostacyclin (prostaglandin vasodilating).

Ke Kula Kaiapuni 'Hoʻokolohua-blockers hoʻohana i like nā māhele, i kekahi like hypotensive hopena. Full antihypertensive 'ole e hoʻomōhala ana i loko o' elua i eha pule. "Ke kāpaeʻana" maʻi pale kānāwai ma luna o ke kāʻei kua o ka lōʻihi-makahiki lapaau. No kona Kāohi lāʻau ua i pani koke, a me ke kiʻekiʻe o emi i ka mahele lāʻau no he umi i kaʻumikumamāhā mau lā.

Systemic waiū ia ai ', pakahi aku la ia ole-e wae, ke hoʻonāukiuki ulu o clinically nui cardiac a noncardiacʻaoʻao' ole.

Ka mua pūʻulu nā kāna hana i loko o ka psycho-mea naʻau kāʻei kua (kaumaha, hiamoe kāna hana, etc.), naehana symptoms (bronchospasm),ʻike ākea vasoconstriction (intermittent claudication, anuʻaoʻao, etc.), Muscle nawaliwali, impotence. Extracardiacʻaoʻao waiwai ho i hoʻopilikia o kaʻaʻa puʻuwai hana, kena ae la ia e hoemi koko i loko o ka hakuʻala, hihia ma ka lipid a me ka carbohydrate pūnao.

Ma cardiac hoikeana pae kikowaena:

• cardiac pumping papa nahae pu me symptoms o ka deficiency;
• blockade (atrioventricular sinoatrialnaya) naau a me ka bradycardia;
• hypotension ku e excessive emi i loko o ke koko,;
• antiarrhythmic hopena.

It E e kaulana i keʻano o ka pharmacological waiwai blocker e leie aku oe, e koho i ka mea e pono ai ke lāʻau Aneane kela hihia. Kēia mea i loko o no a me tolerability o ka lapaau, me ka haahaa pilikia o adverse hanana, ka lōʻihi like 'ole o ka waiū a me ka' ano o ka lapaʻau kulana.

Ka hoʻokohu 'ana Hoʻokolohua-blockers like me ka pau Inc e leie aku no ka normalization ana o ke koko, i loko o kahi o 40-50% o nā mea maʻi me ka hypertension. I e like me ka hopena ma luna o nā mea maʻi i loko o opiopio, waena, a 'oi makahiki, i ka hookoia, kŘpa a haahaa ma ka kūpuna. Ka hoʻohana a thiazide diuretics ma ka hui pu ana, me ka Hoʻokolohua-blocker eliminates oko ao. Ke'ī mai, me ka laulā o ka Inc i loko o ia ka hoʻohui pū maoli i 78-80%.

Hoʻokolohua-blockers e hana angina kūlana 'he kupaianaha wahi. Ma keia maʻi, e hoʻohana 'ia ai' me Anaprillin (obzidan), Sotalol, Atenolol, Konkor, Monotard.

Ke kanawai no a pau o kēia mau ai 'pahuna ma hoemi ke koko, a me ka "deceleration" naʻau kōmi. Ke laʻau heluna o kekahi lāʻau 'E e wae hoʻokahi wale nō kanaka kauka.

Ai 'i contraindicated ma ka asthma, maʻi obstructive pulmonary maʻi, atrioventricular aeie lua a me ke kolu o degere. 'Aʻole pono ka hana o ka Hoʻokolohua-blockers i hoʻopōʻino monakō koko ioeeiiaiey, ʻike ākea arterial maʻi,' âlapa a kāohi hana kanaka.