Medicine "Cyclophosphamide": aʻo no ka hoʻohana 'ana, uku, analogs, ka hoʻohua a me ka hōʻike manaʻo

"Cyclophosphamide" mea he alkylating hui. Kēia lāʻau antitumor hope paha. Ua Ua hua mai la me he keʻokeʻo paha kokoke ia mea pōaka ka pauka. Hou lāliʻi e pili ana i keia k.

"Cyclophosphamide" - ka hoʻohua

E ka lāʻau i loko o ka Lūkini huakai JSC "Biochemistry." Ua Ua Aia i loko o ke kūlanakauhale o Saransk ma ke alanui Vasenko, d. 15A.

kāki o

oe ke kuai i ka lepo №1 «Cyclophosphamide" i loko o kekahi drugstore. Kona kumukuai Ua puni 90-98 rubles.

Ka lāʻau 'ano apau loa

Mai keia he lepo lā, i ka pāʻoihana mea makaukau. Ua Ua manaoia no intramuscular a me ka intravenous hooponopono

hiʻona haku mele 'ana

I ka haku mele 'ana o kēlā me kēia hue me ka lepo kikowaenaʻeleu type waiwai i kapaia "cyclophosphamide". Kekahi mau mea i kona helu. O kekahi mau "Cyclophosphamide" 200 mg o la waiwai no hue. Kēia lāʻau lapaʻau huahana ole excipients.

Description o ka pharmacological 'ana

Ma muli o ka aʻo no ka hoʻohana 'ana, "Cyclophosphamide" - mea he alkylating cytostatic lāʻau. Kona Nine Inch haku mele 'ana, ua like no ka waiwai e like me naikokene makeke. Pharmacological hookoia "cyclophosphamide" mea, e hoʻokō i ka transverse type crosslinking ma waena o DNA a me ka RNA kaula makalii. I keia kanaka e hoomakaukau i paipai 'ia ka kumuʻiʻo hoʻololi kemikala inhibition.

"Cyclophosphamide" - analogues

Ma keia hihia, e koho i na dala e like ka kivila ATH ha waeʻano. Nō auaneʻiʻoukou o ka "Cyclophosphamide". Analogs o keia k, aia nō he nui helu. Ka loa, he pono ole i:

1. "Endoxane".
2. "Ifosfamide".
3. "Alkeran."
4. "Holoxan"
5. "Ribomustin".
6. "Leykeran".

Ke koho ana o kela a me keia o na hoomakaukau hanaia e ke kahuna lapaau e pono ma luna o kekahi kanaka manawa. Ma keia hihia, e lawe i loko no o ka ola kino a me ke ahonui, eiiiiiaiou.

I kekahi manawa, he?

E hoi kakou i keia wahi i loko o hou au mamuli. Nō auaneʻiʻoukou i ka hoʻohana 'o ia i ka lāʻau' like "Cyclophosphamide". Na Ke Kumu no ka hana i loko o kēia e pili ana i ka paʻa mau mea paahana. Ua hākālia nō i ka lāʻau 'ua hoike mai ia ma ka mea i kēia hihia.

1. Inā e 'ike maʻi a me ka huʻi lymphocytic leukemia.
2. Ma ke alo o ka mau myeloma.
3. Inā symptoms o ole-Hodgkin lymphoma.
4. Ma ka hanana o ke mycosis fungoides a me retinoblastoma.
5. Ma ke alo o Hodgkin ka maʻi a me ka ovarian a me ka umauma Ka maʻi 'aʻai.
6. A hiki i ka hoike ana mai o symptoms o neuroblastoma.

Ma waho a pau keia, ua hoʻohana 'ia ka lāʻau i loko o ka hui pu ana me nā ai' antitumor Luna no ka lapaau ana i ka ana ma lalo nei:

1. I ka germ aeea hikoko.
2. Bladder Ka maʻi 'aʻai, a akemāmā.
3. Sarcoma oʻaeʻae'aʻaʻa type.
4. Ma ka hanana o ke prostate a me cervical Ka maʻi 'aʻai.
5. A lohe o Ewing ka sarcoma.
6. Ma ka hihia o Wilms 'hikoko.
7. I ka retikulosarkome.

I ka hoʻomākaukau me "Cyclophosphamide", pane i nā 'oluʻolu, ua mana e like me he immunosuppressive Agena' ano me ka holumua ai hoike ana o autoimmune ka maʻi. Ma keia hihia ka mea, 'o ia hoʻi keʻano o psoriatic a me ka rheumatoid arthritis, autoimmune hemolytic anaemia, collagen, nephrotic maʻi pale. Pū akula hoʻi suppresses pakuiia auanei lakou rejection naoh.

Contraindications

"Cyclophosphamide" i kekahi contraindications. Ua hiki ole ke hoʻohana:

1. Iloko o ka breastfeeding wā a me ka hāpai keiki.
2. Ma na hiohiona kue o ka iwi lolo kuleana pili i.
3. Inā symptoms o hypersensitivity.
4. I ka kali hou aku; urination.
5. Ma ke alo o ka hana nā mea palahēhē.
6. Ma ka hoike ana o ka cystitis.

Ke mālama nui Ua pono "Cyclophosphamide", analogues o i i helu 'ia ma luna, lawelawe ma kekahi mau hihia. ʻo ia, i ke alo o ke kēia mau maʻi:

1. Nefrourolitiaza.
2. Loa naau maʻi, ake a me ka hakuʻala.
3. Gout.
4. ʻeho infiltration o ka iwi lolo keena.
5. Adrenalectomy.
6. Suppression o ka iwi lolo kuleana pili i.

Description o kaʻaoʻao loa

"Cyclophosphamide", synonyms (analogues) i mea i hoakaka ia maluna, e hoʻonui i ka muli o ke kēiaʻaoʻao ole:

1. Ka digestive'ōnaehana e hoike symptoms e like me ka luaʻi, nausea, anorexia, discomfort, stomatitis,ʻeha ma ka abdominal wahi, diarrhea paha constipation. No hoi i ike i kanaka hihia o ka jaundice a me ka hemorrhagic colitis.
2. Ma ka hematopoietic'ōnaehana hoikeana i malama neutropenia, anaemia, thrombocytopenia, leukopenia. Ma ka lā 7-14? Eaia e iki emi i ka helu ana o platelets a me leukocytes.
3. Ma ka ili hoikeana o alopecia malama. Ulu lauoho hou ma hope piha lāʻau. Eia hou, i ka iapaau ana kānāwai ma luna o ka ili poʻe noʻonoʻoʻole. He hiki no hoi ia i ke alo o ka pigmentation o kaʻili, a kui loli.
4. Ma ka mea'ōnaehana mānowai koko'ōnaehana ka wā lawelawe kiʻekiʻe nā māhele o ka lāʻau ma luna o ka lōʻihi manawa au e ia he kīnā o ke cardiotoxicity. He nui ke hoomanao. Eia hou, ua malama i ke muli o ka luna ', a me kekahi manawa ona e, na hihia o ka naʻau ole. Keia mea aie a hiki i ka hanana o ke myocarditis hemorrhagic type.
5. Ma ka urinary'āpana hiki i necrosis o kaʻaʻa puʻuwai auwai a (a me ka make), hemorrhagic cystitis a urethritis, urinary bladder fibrosis. Ma pohihihi keia hihia, i ka noi o kiʻekiʻe dosages o ka lāʻau i hana nephropathy, hyperuricemia a me kaʻaʻa puʻuwai kuleana pili i. Ke alo aku o ka epithelial keena ma ka mimi ke kānāwai.
6. Ma ka naehana'ōnaehana i ia he kīnā o interstitial pulmonary fibrosis.
7. Ke reproductive'ōnaehana kāna hana ke hana oogenesis a me ka spermatogenesis, a me ka sterility. Hope i symptom ma kekahi hihia mea paha e irreversible. Ka hapanui o nā wāhine i loko o ka noi o ka Agena malama i ka hooulu ana o ka amenorrhea. Ma hope o ka lapaau, o ka regularity o menses pele ua ho'ōla mai kēlā. Men lawe i ka lāʻau 'ke alakai i ka muli o oligospermia a azoospermia, e like me loli iki degere o testicular atrophy.
8. Ma keia hihia hiki e malama a me ka allergic reactions. Ia mea he kīnā o ka ili poʻe noʻonoʻoʻole, ka ohane, hives, anaphylactic reactions.
9. ¶ A i loko o keia hihia, aole e ia i ka hanana o kaʻaoʻao loa. Ie koko i ka lehalehu tʻili, redness, malignant kiʻekiʻe hikoko, excessive sweating, headaches.

ano o ka AaOIeIOUIeXAOAaIN

I ka loaa ana keia k, kekahi kumu e hoʻonui i ka microsomal'okesaside ma ke akepaʻa, e hoʻokō i kaʻinaʻonou microsomal pūnao o cyclophosphamide. Ua hiki aku ai i kekahi mau aʻe. ʻo ia, a hiki i ka ho okumu nui alikiliruyuschego type metabolites. Kēia ho'ēmi i kā ka wā no i ua lawe mai ka hapa-ola o ka cyclophosphamide, a me maoli kona hope. Cyclophosphamide, a ua hoʻolōʻihiʻia markedly a inhibits cholinesterase aayoaeuiinoe, hoʻohuiʻana paha i ka hana o ka suxamethonium. mea no hoi e kokua i ka ho'ēmi i 'ole' ūlōlohi mai ana i ka pūnao o cocaine. E like me ka hopena, hoʻokāʻoi a mahuahua lōʻihi like 'ole o kona ai, a maoli he i ka pilikia o kaʻawahia loa. Kēia i ka hopena maikaʻi ia ma luna o ka meaola holoʻokoʻa. Eia hou, i ka i ka wā hoʻokahi noi o allopurinol e hoʻonui i kaʻawahia 'ole ma ka iwi ka lolo.

I ka ke kākoʻo '-lawelawe me ka cyclophosphamide allopurinol, colchicine, probenecid, sulfinpyrazone e pono ai? Iaea nā māhele protivopodagricakih' ano ai 'ma ka lapaau ana o gout a me ka hyperuricemia. No hoi, i ka wa a keia mea ulu e hoike nephropathy kamepiula i ua pili i hoonuiia? Iecaianoaaiiuo o uricʻakika hoʻohana 'cyclophosphamide.

Ka hope waiwai hiki i ka mahuahua ma ka anticoagulant hope. No keia hoʻololi kemikala ma ke akepaʻa emi kumumea ka paepaeʻana koko clotting, a hihia hoʻi platelet? Iecaianoaaiiuo. Eia naʻe, he hiki no hoi i hoʻomaka ai i ka emi anticoagulant ha awina ma kaʻikeʻano papa hana type.

Cyclophosphamide hoʻokāʻoi aʻe ana i ka cardiotoxicity o daunorubicin a me ka doxorubicin. Other immunosuppressive konohiki (chlorambucil, azathioprine, tacrolimus, corticosteroids, mercaptopurine, etc.) e hoomahuahua i ka manawa kūpono o nā haumāna nā mea palahēhē a me ka hikoko.

Ke i ka wā hoʻokahi 'ana o ka lovastatin i loko o nā mea maʻi me ka naau transplantation ke hoʻonui i ka pilikia o ka maʻi e like me rhabdomyolysis a me ka huʻiʻaʻa puʻuwai' ole.

Inā ma ka hui pu ana, i keia k ua hoʻohana 'ia myelosuppressive ai' ole ka pāhawewe Inc, he mea hiki hoakaka ana'ku mea hoʻonui inhibition o ka iwi lolo kuleana pili i.

I ka wā hoʻokahi aaieieno? O cytarabine ma kiʻekiʻe nā māhele me ka mea e like me cyclophosphamide, ma ka hoomakaukau kahua i ka iwi lolo transplantation kaʻina hiki aku ai i cardiomyopathy me ka ulu alapine (frequency) hoouka kaua o ka make.

Ka papa kuhikuhiE ana hoʻohālike

Ma ka noi i loko o ka mooolelo o kēia:

1. Iloko o ka iapaau ana me keia k e mau lawe mai i kekahi koko ho'āʻo e Loiloi i ka loa o ka myelosuppression. He pakahi aku la ia e pono ai, e hoʻolohe i ka helu ana o platelets a me neutrophils.
2. Oe E kekahi mau hāpai mai i ka mimi ho'āʻo no ke alo o kaʻulaʻula koko aeea helu. Lākou alo aku e hoʻonui i ka ulu ana o na maʻi like hemorrhagic cystitis. Ma ka loaʻaʻana o ia mau symptoms lapaʻau me "Cyclophosphamide", ke kumukuai o ka i ua helu 'ia ma luna, oe e hooki aku.
3. E like me ka helu o nā platelets (emi o 100.000 / ml) a / a keʻokeʻo keena koko (<2500 / L) o ka loaa ana lā hoʻi e hoʻi i kāpiliʻia.
4. I ka maʻiʻaʻai ia lŘlŘ i loko o ke au o ka lāʻau Inc, i mai la lapaʻau e e nōʻoe, a keʻakeʻa. Ina e hoomaikai aku i loko o ka hihia o ka loaa ana i ka laʻau heluna e hoemiia e. Na kanaka a me na wahine i ka iapaau ana kaʻina hana, "cyclophosphamide" mea pono e hoʻohana 'ike loea ano o ka contraception.
5. Ma Inc me keia k Pono, e hookaaokoa lakou mai ka waiʻona.
6. Ma ka hihia ma ka hala mua he umi mau lā ma hope o ka hana, a i lawe mai ma lalo o mau anesthesia, a me ka hoʻomanawanui i hoakaka ia "Cyclophosphamide", ke kumukuai o ka i ua helu 'ia ma luna, oe e hoike aku i ka anesthesiologist waiho.
7. Hoomanawanui ma hope iho o kona paʻa adrenalectomy, ia mea e pono ke lawe mai lakou malama ana i ka laʻau heluna hoʻoponopono e like me nā corticosteroids, a i hoʻohana no ka hope Inc kaʻina hana, a me ka ia i ka lāʻau ', like me ka lapaʻau, "Cyclophosphamide".

pono kaiapuni

? Eaia o ka lāʻau mea hiki ma lalo o ka hooponopono ana o kekahi kahuna lapaau e loaʻa ka hoao ana i ka chemotherapy wale. Ua E hoi e kānana kaʻaeʻana i ka laʻau heluna? Eia. Kēia E e hana oi loa aku hoi ma ka hui pu ana, Inc. No hoi, e ole pono e kali i ka pili a pāpālua hoʻi o ka mahele lāʻau ina ka mua kekahi i lilo. I ka makaukau ana o keia k no ka hoʻohana i na kamalii uuku ia i paipai i ka hoʻohana diluents i pihaʻi me benzyl ka waiʻona. No keia hiki alakai i ke kūpono 'ana o ka onaʻawahia maʻi pale. ʻo ia, a hiki i ka helehelena o metabolic acidosis, CNS kaumaha, naehana hanu ole,ʻaʻa puʻuwai e hemahema, hypotension, ke kāʻili 'ana, intracranial hemorrhage.

I loko o ka papa holoʻokoʻa o ka lapaʻau ua? Aeiiaiaoaony e lawe mai i kekahi koko transfusion (1 manawa no hebedoma 100-125 ml). Kēia E e hana ai no ka hana o ka Kāohiʻana o ka maʻi e like me hyperuricemia a me ka nephropathy, i mea ku pono i ke kahua o ka mahuahua dala o uricʻakika. Mau symptoms pinepine ana i ka hoʻomaka o ka iapaau ana wā. Nō hoʻi, mamua, e olelo aku lāʻau Inc, a iloko o 72 hola ma hope o aaieieno? Ua? Aeiiaiaoaony e hana i kekahi loliʻai ana (ma kahi o 3 nā lika o ka lā), ka pono o ka allopurinol (i loko o kūikawā hihia), a me nā mea i i kona'ākilikai mimi. No ka mea Kāohiʻana o ka hoikeana o ka hemorrhagic cystitis mea pinepine pono e lawe mai emptying o ka bladder, a no ka lawe "UROMITEKSAN". Inā he loiloi mua hoailona o ka maʻi, i ka laau mai la hoomakaukau e E pani a ka piha hoʻopau o kekahi symptoms.

E attenuateʻano dyspepticʻike manaʻo ke lawe cyclophosphamide loko o ka lā mua o ka poe liilii, nā māhele. Piha a hapa alopecia, a e hana ana i ka lapaau mea reversible, a ma hope o ka papa ua hoemi hana o ka lauoho ulu maʻamau. Eia naʻe, kā lākou mau waihoʻoluʻu a me ka 'ole i hoʻokuleana i ka hoʻololi' ana i.

Inā e 'ike' ole, ke kuni, cough a hoarseness,ʻeha ma ka lalo wahi hope, a ma kaʻaoʻao, eha paha pilikia urination, kahe ana ke koko a me kahe ana ke koko, eleele pā holoi, ke koko i loko o ka noho 'ole mimi lakou e ike koke nīnau aku i ke kauka.

I ka manawa kūpono o ka thrombocytopenia, e alakai ana i ka pono no ka kūikawā i nā hana e like me invasive ke kaʻina hana a me nā kahua niho kaʻina hana. Ka mea, e mau nānā i kaʻili, a me ka mucous membranes a me ka intravenous paena. Kēia mea ma ka mea e huai ae i na hoailona o ke kahe ana ke koko. Ua mea i pono, e kali i ka alapine (frequency) o ke venipuncture, a hoole intramuscular ka pahu kui. He mea pono i ka mana i ke koko maʻiʻo ma feces, luai, mimi. pono hana kēia mau hoʻomanawanui iki mai me ka lōʻihi mālama nui ka umiumi, komo kaʻina, manicure, dentifrices, toothpicks, etc. Spaces I ka Ia manawa e e malama ikaika käpae 'Falls, a me nā nā palapū. Acetylsalicylicʻakika a me ka waiʻona ua i papa ia e hoomahuahua i ka pilikia o gastrointestinal kahe ana ke koko. Ma keia hihia ia mea e pono e hoʻokō i kekahi manaʻo kali hou aku vaccination haʻalele 'ana (ma hope o 3-12 mahina ma hope o ka hope chemotherapy papa paa). He kupono e pale aku hui 'ana me infectious nā mea maʻi. Ma lapaʻau ia mea pono e pili kūpono contraceptive ana.

A pau ka hoʻomaopopoʻana mai la lāʻau me ka mucosa a ili pono e ho'ōla loa holoiia me ka papu ka wai i ka hapa a me ke kopa, niioaaonoaaiii.

Breastfeeding a me ka hāpai keiki

Aia He auaneʻiʻoukou i kaupalena 'ia ma keia manao, a i ka "Cyclophosphamide". Manual Hōʻike i contraindicated o ka hana ana o keia k i hāpai keiki. Ma keia hihia, no ka waeʻano o ka hopena ma luna o ka fetus denoted «D» e FDA. Ma lapaʻau ia mea e pono ke hele breastfeeding.

overdose

Ma keia hihia, eia kekahi mau nuances. Ke alo aku o kekahi mau 'antidote me ka overdose o ka la hoʻomanaʻo mea IKE OLE IA. He He loea mea. Ma overdose noi pono hoʻokō i ke kākoʻo nui ana me kūpono lapaʻau o infectious maʻi, e like me kaʻatikala o cardiac a / a myelosuppression.

waho pūnaewele ana

Ma keia manao, e pono i kekahi mau rula e like hoʻomākaukau me "Cyclophosphamide". Na Ke Kumu no ka hoʻohana stipulates i ka mea pono e waiho waho i ole e oi aku 10 ° C ma ka wahi i mea maloʻo ana wela a me ka palekana mai ka malamalama. Ma ke kōkua o kēia keiki i ka ia ia e ke kapu.

holopapa ola

Aia o kekahi kōā o ka manawa a ma ia mea i ka lāʻau hiki ke hoʻohana i "Cyclophosphamide". Na Ke Kumu no ka hoʻohana i ka 'i kona hana ola o 3 makahiki. Ma keia hihia, oe e hoopili aku i kekahi mau ana. , Ae waiho nei ma ka mea i ikaika ke hookapu i ka hana ana o keia k ma hope o kēia wā make.

manaʻo

Ma keia olelo, he mea no hoi i ke ano o ia mea "Cyclophosphamide". Na Ke Kumu ma ka noi Hōʻike i ka lāʻau 'ua hookuu wale i loko o keʻena kūʻai lāʻau lapaʻau ma kuhikuhi.

ka hopena

Ma keia kikokikona, aia no he wahi lihi iki o ka maikaʻi kēia 'ike. A me ka pono ka mea he "Cyclophosphamide", aʻo no ka hoʻohana 'ana, i ke kumukuai o keia k. Eia naʻe, i kekahi ia e amo ai i ka manaʻo i mua ana i ka lāʻau, e kukakuka pu me ka palapala hōʻoia no kauka.