Antiplatelet konohiki: papa inoa o ka ai '. Anticoagulants a me antiplatelet hope, i ko lakou mau ano

Mahuahua kahe ana ke koko pinepine ke kumu no thrombosis, a hiki aku i ka loa ka hopena, a me ka make. Pharmacology E hana 'ia ae hoola ola o nā mea maʻi me ka ia kāna hana ma muli o ka mālama' ana i Inc like loaa antiplatelet ai '.

He aha nā anticoagulants?

Rheological waiwai o ke koko, e pepehi i ke koena ma waena o coagulation a me ka anticoagulation nenoai. Ma ka malama ana i kēia koena me he maoli anticoagulant komo antithrombin III a me heparin, a hana pololei antithrombotic papa, i ua, pale aku i ke kahua o ke koko clot. Keʻano papa hana o ka hana ana i ka la mahope, ua pili i ka hana i ka luna 'me ka antithrombin III, kūpono ana ma ke kahua o kaʻeleu antithrombin. He, ma ka huli, he kuleana no ka paa i ka thrombin, ana ia AEeOEXAaI - ia ka poʻea pau i ka inhibition o thrombus ho okumu. Antithrombin III iho no hoi, ua anticoagulant waiwai ma ka inactivating thrombin, nae, o ka naoh puka loa lohi.

I ka hiki ana o heparin e hōʻoia 'inactivation o thrombin hilinaʻi nui ma luna o ka nui o ka antithrombin III i loko o ke koko. Koi mahele lāʻau hoʻoponopono ua koi 'ia ma muli o ke Ka Ikepili. Pinepine he pono ke kohoia ana o na ai 'elua i ka manawa hookahi - heparin a me ka antithrombin III, ma ka ia laʻau heluna i wae pākahi no kēlā me kēia kanaka.

Paa i ka antithrombin - i ka wale hana o ka heparin. Eia hou, oia mea hiki ke uhai iho fibrin me ke komo 'ana o ka plasmin, ua kapa ole-enzymatic lysis. Kēia naoh o ke kahua o nā hui me keʻano o ka biologically hana waiwai, me peptides a me hormones. I waena o nā hiʻona maopopo i ka suppression o ka helu o nā'ūhū komo i loko o ka hoʻoʻino kaʻina (ho'ēmi i kā kona pinepine '), e like me ka ho'ā hope o ka lipoprotein lipase a me ka hoʻoikaika' ana i ke koko kahe i loko o nā ipu naau.

He aha ka ka antiplatelet konohiki?

Hoomakaukau anticoagulants a antiplatelet Luna i ka pono ia ma ka laau lapaau. Kēia inoa i loaa na dala, i inhibit ka ka ponaʻana (aggregation) o ke koko keena - ulaula koko keena a me platelets. Keʻano papa hana o ka hana ana i kēia mau 'ona mea okoa, i ae kekahi mau pūʻulu. Antiplatelet konohiki, nui ka papa inoa o ka ai 'a i hoʻolaha like penei.

1. Kalipuna hakaka ( "Verapamil").
2. 'ūhū nā mea kūpale, i nā waiwai i uhi cyclooxygenase (acetylsalicylicʻakika, "naproxen", "Indomethacin"), a me ka adenylate cyclase a me ka phosphodiesterase ( "Ticlopidine", "Pentoxifylline").
3. Ai 'i hoʻoulu i ke kahua o ka prostacyclin ( "pirazolinov").
4. Prostanoids ( "Prostacyclin" a me kona analogues o kemikala me Kinohi).
5. Ai 'e uhi i ka hookuuia ana o' ona na ma platelets ( "Pyracetam").

hoike

Antiplatelet ai '- ai' nona ka inoa i ike i na mea he nui no i ke ākea noi. O ka papa kuhikuhi hana o keia pae - o ka thrombosis prophylaxis. Antiplatelet ai '- ai' i ka pono pili i ka helu o ka mea'ōnaehana mānowai koko pathologies, e like me ma hope oʻoki kino (prosthetic naʻau kiwikā).

Antiplatelet konohiki: papa inoa o ka ai 'i mea mau i hoʻohana i ka' inikua hoʻomaʻamaʻa

Ai 'e pili ana i keia hui, loa ai i ka puu, a me ka mea a pau i kā lākou mau peculiarities. Koho ana o ka lāʻau hilinaʻi nui ma luna o ka lapaʻau hihia. A, o ka papa, pakiko-ka lapaʻauʻia i loko o keia kulana mea ole.

"Aspirin"

Ma ka rula o ka hemostasis eicosanoids e hoʻomau ana i mea i ka huina hoonui o ka'okesaside o arachidonicʻakika. Mawaena o ka mea nui o ka thromboxane A2, a me kona papa kuhikuhi hana - kaulike platelet aggregation. I ka hana o ka aspirin ua kuhikuhi ia inhibition o ka'ūhū, kapa cyclooxygenase. E like me ka hopena o keia hoʻololi kemikala ua uhi pū tomboksana A2, nolaila, inhibited thrombus ho okumu keʻano o ka hanaʻana. Ke kanawai maoli he wā hou-e lawe i ka lāʻau ma muli o ka hoʻomāhuahua. No ka piha inhibition o cyclooxygenase koi 'ia i kela laʻai ana. Na kaʻoi loa laʻau heluna ho'ēmi i kā ka likelihood o kaʻaoʻao waiwai, "Aspirin" a hiki me ka mau ana. Mahele lāʻau escalation mea unacceptable, mai ka mea, no ka pilikia o ke kahe ana ke koko complications.

"Ticlopidine"

Na ai 'i ka nānā' ana ma luna o ka paleʻana i kekahi mau receptors i nā kuleana no ke koko clots. Maʻamau, ka wā e kuhikihi ana iā ia ma laila mea he loli o ADP platelet aggregation hauma¯na kahi a me ka hoʻokino, a "Ticlopidine" inhibits keia kaʻina. A hiʻona o ka antiplatelet konohiki mea he kiʻekiʻe bioavailability, a ua loaʻa ma kiʻekiʻe māmā omo. Ma hope o canceling hookoia ua malama a hiki i 3-5 lā. Ke drawback o ka nui helu o kaʻaoʻao waiwai, a me na nausea, diarrhea, anaemia, a agranulocytosis.

"Clopidogrel"

Antiplatelet konohiki e like me keʻano o ka hana mea i 'ano like me ka "ticlopidine", akā, kona pono o ka kŘpa a haʻahaʻa kaʻawahia. Eia hou, i ka pilikia o ka wā e lawe keia kʻaoʻao 'ole ka nui emi. Ma keia manawa i ka hoʻomalu haawi makemake i "clopidogrel" aie a hiki i ka wa e kaawale aku o complications e like me agranulocytosis a me ka thrombocytopenia.

"Eptifibatide"

Ka lāʻau 'haawi aggregation ma ka paleʻana i ka glycoprotein, i ua aia i loko o ka plateletʻili lahilahi. Ia no ka intravenous bolus, IeAUPIIe, IAa IO ma angina a me ka angioplasty e emi i ka likelihood o myocardial infarction.

"Dipyridamole"

I ka papa kuhikuhiE hopena o ka lāʻau - e kaukaʻi vasodilatation, oa ke anoe ana o na moku koko, akā, kaheaia antiplatelet hookoia ua malama ka wā hui me'ē aʻe ai '. "Dipyridamole" i'ōleloʻia ai me ka "aspirin", ina he mea kekahi kamepiula kiʻekiʻe o ke koko clots. Ua mea i hiki ke hui pu iho la me ka "warfarin", i ua pono pili ma hope o ka prosthetic naau kiwikā e emi i ka likelihood o embolisms. I monotherapy ai ka emi hai.

Antiplatelet ai '- ai' (o ka papa: "Elikvis", "clopidogrel" a me na mea e ae), ua hoʻomano hoʻohana ma ka hoʻomaʻamaʻa.

Contraindications

Ka hoʻokohu 'ana i antiplatelet Inc pono akahele mōʻaukala, i nā hōʻike ma comorbidity. Ma ke alo o ka maʻi i mea he contraindication no ka loaa ana i ka ai 'loko o keia hui, he? Iaea o ka iapaau ana kumumanao. Ma ia ano hihia, he koho ana o kanaka, ai 'a me kā lākou mau dosages, a me ka lapaʻau ua lawe mai ma lalo o ke kanana' 'inikua hooponopono. I ole hihia, e he kuokoa hookohu o antiplatelet hope, no ka mea, o ka hopena hiki e disastrous.

Ka papa inoa o nā contraindications:

• allergies;
• hemorrhagic diathesis;
• ka pilikia o ke kahe ana ke koko;
• loa ake a me ka hakuʻala insufficiency;
• mōʻaukala o ka arrhythmia;
• hypertension, loa;
• obstructive maʻi o ka naehana oihana;
• Children ka makahiki (no ka hapanui me nā huahana).

Eia hou kekahi, he nui wale o ka antiplatelet konohiki (i ka papa inoa o nā huahana nānā 'ia ma kēia' atikala) e contraindicated i hāpai keiki, a lactation. I loko o kēia wā, e e he makemake ko ai 'i ua pakele no ke keiki, a no ka makuwahine.

Antiplatelet konohiki. Ai ': i ka papa inoa o ka hāpai keiki

Inā e kue ana i ka fetal holo i ka pilikia o ka abortion. O kŰia ua kapaia fetoplacental insufficiency. Inā e kue ana i ka haawi ana o oxygen a hiki i ke koko o ka fetus ulu loa hypoxia, i Hoʻoweliweli 'ole wale i ka likeʻole i loko o kona ulu ana, akā, i ka make. I ka diagnosing kekahi pathology pono ke ake lapaʻau, a he loko o ka hoʻomaikaʻi koko, hoemi i ke koko (viscosity). No keia a ua waeia antiplatelet hope, nae, e makaala i ole ai ka ai 'a pau i loko o kēia hui e pakele i hāpai keiki. Hiki ke hana wale i kekahi o na dala.

"Kurantil"

Ka lāʻau 'Ua loa mahalo no i ka mea i loko o kona papa inoa o contraindications i hāpai keiki, a breastfeeding. ʻeleu 'Oponopono "chimes" - i hōʻike mua dipyridamole, i dilates ipu koko a inhibits thrombus ho okumu. Ua hoonui ae i myocardial koko, kaulike i ka haawi ana o ke koi nui o ka oxygen. Ma keia ala, K "Urantia" hiki ke hoʻohana 'ia i loko o ke alo o ka mea'ōnaehana mānowai koko maʻi i loko o hapai wahine. Naʻe, i ka papa kuhikuhiE PAaIEN no ka hapai ia mea placentofetal ole. Ma ka hoʻomaikaʻi rheological waiwai o ke koko a me ka vasodilatation, Kāohi puka liiiU ipu o ke keiki, no laila, ke fetus aole i hana eha iaʻi mai ka hypoxia. A hou pomaikai o ka lāʻau hiki ke kapaia immunomodulating hopena. Ke k stimulates ka? Iecaianoaaiiie o interferon, hiki hoemi i ka pilikia o ka mea hoʻomaʻi maʻi i loko o ka makuwahine. ʻOiai "Kurantil" a me ka mea hiki ke hoʻohana i hāpai keiki, a lactation, akā, e wale i koi 'ia inā hōʻike. Oiai ka lawe i ka lāʻau e emi i ka hokii o ke kī a me ka kope me ka mea emi iho kona laulā. Antiplatelet ai '- ai' (papa luna) i e ole e hui me ia i ka mea inu. 'Oiai, hāpai keiki ua i aʻo aku ai iā ia e ia e komo ai i loko o kekahi alanui.

Antiplatelet konohiki, he papa inoa o ka ai 'i nā ōlaʻi i ka inoa, e hoʻohana ka pono ma ka iapaau ana o ka maʻi o ka mea'ōnaehana mānowai koko nenoaiu. Eia naʻe, e ike no ka hiki complications pili i ua hoʻemi koko (viscosity) a me ka clotting inhibition. Antiplatelet ai '- ai' ana e hoʻohana hiki ma lalo o ka hooponopono ana o ka mea e hele ana i kahuna lapaau wale,ʻo ia, e lawe ia i ka mea e pono ai laʻau heluna a me ka papa o ka nohoʻana.