Gamma-interferon: ke ko'iko'i a me ke ko'iko'i o ke kino kanaka

No ka pale'ana i ke kino o ke kanaka mai ka hopena ho'omāinoino o nā pathogenic pathogens - huakō, he mechanics ka pūnaewele pili i ka hakakā'ana i nā ma'i ma'i. 'O ia ka hana'ana o nā pūnaewele, me he la'ana, nā T-lymphocytes, o nā mea kūikawā, kahi o ia mea he gamma-interferon. Ho'okumu'ia i loko o ka pūnaewele papahana, ho'okani ka pūpū i ke kuleana o ka pale pale pūnaewele. No ke aha i ko'iko'i loa ai ka hana'ana, a me ke'ano o ka hana a ka pilina o ke kino - nā nīnau e loa'a iā mākou nā pane ma kēia'atikala.

Ke Nine Inch 'ole a me ka loaa ana

'O ke kumu o ka waiwai he glycoprotein, kahi peptide i ho'opa'a'ia i ka wai'ahu. Ho'oka'awale'ia nā'ano'elua o nā meaola e like me ka mea amino acid o ka mua a me 139 mau monomers ma ka kaula polypeptide. Kapa'ia lākou he gamma-interferon 1 a me 2a. 'O ka mīkini kaumaha ma'amau e like 20-25 kDa. Ho'onoho'ia i pane no ka ho'okomo'ia'ana o nā'ōpala a me nā pūnaewele o nā mea ma'i pathogenic e hō'ike'ia ana e nā'āpana viral. Ma lalo o nā kumu kūikawā, loa'a ka waiwai ma nā'ano o ka biotechnology a me ke enekelikene pūnaewele e ho'ohana ana i nā'eha o ka bacteria E. coli,'o ka plasmid o loko o ka pūpū interferon kanaka. Kapa'ia kēlā gamma-interferon he recombinant, he hapa ia o nā ho'omākaukau'ana: "Imuneron", "Ingaron", "Immunomax".

Ka hana o nā hana kūpono'ole

'O ke'ano i loko o ke kino o nā ma'i pathogens malihini e hele pū me ke'ano o nā papa hana palekana, ho'okahi o ia mau wela. 'O ia he hō'ailona e hō'ike ana i ka ho'omaka'ana o ka ma'i a me ka pane o nā pūnaewele i nā antigens o ka pathogen. Aia kekahi paakiki o nā pilina ma waena o nā mea o ka ma'i a i'ole ke kīpona. Ho'okumu'ia ia ma nā mea i hana'ia e nā pūnaewele o ka'i'o lymphoid: cytokines (lymphokines). Eia kekahi la'ana,'o ke gamma interferon kanaka, interleukin 2, ma o ke'ano o ka membrane interactions, ke ho'oikaika i nā pūnaewele i'ole e pilikino i ka ho'omaka'ana i ka inoa o nā pū'ali āpau, a,'o ka mea'oia'i'o, he mau hō'ailona kēia. E no'ono'o nui kākou.

Nā'ano o lymphokines

I loko o 6 mau paila o nā chromosomes kanaka he kahi kahi i loko o ka pū'ulu o nā genes e halihali ana i ka'ike e pili ana i nā waiwai antigenic o ka membrane cytoplasmic a me nā mea'ē a'e o ke kelepona: nuclei, mitochondria, etc. 'A'ole hiki i nā lymphokine ke ho'ololi pono i nā antigens o nā mea'ino, akā ua ho'ouna wikiwiki lākou i ka'ike e pili ana i ke komo'ana o nā mea'ē mai kahi pūnaewele i kekahi. Eia kekahi la'ana,'o ka'āpana antigen o ka heluna kōkua a me nā T-lymphocytes TOR e ho'okomo i kahi hō'ailona intramellular, e ho'ouka ai i'elua mau proteena kūikawā. Hou i loko o ka lymphoid'aʻaʻa ua hoʻokāʻoi mitotic mahele kaʻina - ka hoʻonuiʻana, a me ka aeea-mediated e hoʻonele ua nui mahuahua. E like me nā'ano lymphokines,'ehā ka gamma interferes me nā hana o ka transcription o ka waipika nucleic viral, a hana pū i ka mechanism o ka hui'ana i nā moleculo kinaila o ka pathogenic pathogen. Hiki ke'ōlelo'ia,'o ka pūmua pūnaehu i'ike'ia e mākou,'o ia ke kumu o ka ho'opa'i palekana.

Pehea e hana ai ka pūnaewele ho'oponopono

'O ka momona o Thymus, nā lihili'u, palatinine tonsils, ke'āpana o nā wahi o nā lymphocytes. Hiki i nā pūnaewele ho'omalu ke hana i nā mea palepili e ho'oke'ake'a i ka ulu'ana o ka ho'omaka'ana o ka ma'i ma ke kino. I nā lā mua o kā lākou ulu'ana, nā pūnaewele o ka pūnaewele immune, i kapa'ia he naive, hiki'ole ke hahai i nā antigens haole, bacteria a me nā ma'i. Pono lākou e o'o a lilo i po'e kōkua'ole - hiki kēia ma ka laumus. 'O ke kino pūnaewele, ka mea nāna e ho'opuka nā pūnaewele'elua: macrophages, T-lymphocytes, killer cells, and various types of gamma-interferon, e ho'omalu'ia e nā kikowaena ki'eki'e o ka lolo.

Ho'oponopono'ia kāna mau hana e nā'ale'a o ke kino, ka pituitary gland a me ka hypothalamus. 'O nā ma'i a me nā mana'o no ka na'au, ka'ai'ole ka maika'i a me nā mea maika'i'ole e ho'oemi i nā pane o ke kino a me ke'ano o ka pilikia. Ma muli o ka pane o ke kino ka hopena o ka hana o kona mau pūnaewele, hiki i ka hō'eha o ka homeostasis ka hopena a me ka hō'ino'ia o ke olakino.

'O nā kinakoki i ke kanaka āpau gamma

I loko o ka'oihana olakino, ua ho'ohana'ia nā meaola e mālama'ia ai nā protein i loa'a i ka lā'au āpau o nā holoholona me ka interferon recombinant e like me ke'ano palekana a me ka mea ho'oponopono kino. Ho'okomo'ia ka mole anti molekino mai ke koko koko, ho'oma'ema'e'ia a ho'ohana'ia me he lā'au hō'ailona. Hiki iā ia ke ho'onui i ka hana o kāna pū'ali pale pono'ī o ke kino, e like me nā gamma globulins, a me ka hō'emi'ana i nā hō'ailona o ka ma'i o ka'ōpū hanu: ka ihu a me ka'ākau āpau, ka ma'i.

'O ka hopena maika'i o ka pale

Aiiay glycoprotein inhibits ka multiplication o nā mea hoʻomaʻi a stimulates aeea nā'ūhū, e like me kumuʻiʻo kinase adenilatsintetazu a me ka hoomaopopo ana suppression o ka hoʻololi kemikala o nukelea nāʻakika a me nā polokina o ka mea hoʻomaʻi wahī. Hiki i ka waiwai ke ho'oikaika i ka pilikino o nā protein cellular membrane i nā lymphokines,'o ia ho'i, he immunomodulator. Ho'omaopopo ka Gamma interferon no nā keiki a me nā mākua no ka pale'ana a mālama'ana i nā ma'i pīnī a me nā ma'i o ka'ōpū, me kahi hi'ohi'ona maika'i no ke kū'ana o ka'ōpū o Koch i loko o ke kino. Hiki ke lā'au lapa'au ma ke'ano o nā papa, nā mea'aila, nā mea ho'omana'o a me nā hana'ākau.

'O ka ho'ohana'ana i kahi lā'au lā'au i kauoha'ia e ke kauka e hiki ke ho'omaka'ia i nā keiki mai nā mahina 6 mai, e no'ono'o ana i ka loa'a'ole o nā ma'i mai ka ma'i a me nā ma'i o ka pūnaewele cardiovascular. 'O ka ku'una i ka mālama'ana i nā wāhine he ma'i pākiki a me ka hāpai. Ho'omākaukau hou kēia mau mea, i ho'ohana'ia i nā pediatric, i loko o ka protein me ka ki'eki'e o ka ho'oma'ema'e a me ka puka'ole o nā'āpana polypeptide.