I ka makaukau ana o Hepatitis C "sofosbuvir": hōʻike manaʻo, kuhi no ka hoʻohana

Uluwehi O "sofosbuvir" me ka oihana inoa "Sovaldi" e leie aku oe i ka loa hoola hepatitis C, i ka maikaʻi hopena ua loaa koke lawa, a ua hookupaa iho la ia ma ka lapaʻau haʻawina.

Uluwehi O "sofosbuvir" hana maʻi hepatitis C shape. Hui Inc me ka hana ana o keia lāʻau a me nā ai 'lawelawe ai i kanaka makua nā mea maʻi. Medicine, a hana nā mea maʻi me HIV ke kākoʻo '-maʻiʻaʻai.

Kaʻeleu ke keʻena o ka papa - sofosbuvir. Lakou i lole komoʻuʻuku nona, a ke komo 400 mg o na kumu o ka waiwai. Ke AEeAaOA be 28 na papa.

Ka waiwai i lāʻau e poipu "sofosbuvir"

Ka lāʻau e kaumaha ana ia ma luna o RNA-polymerase NS5B. E like me ka hopena, kona kanawai ma ke kino o inhibited mea hoʻomaʻi replication kaʻina hana, i mea ka causative Agena o hepatitis C.

Where e kūʻai "sofosbuvir" ma ka affordable kuai

Ka loa maikaʻi kēia hōʻike ma pehea e loaa ka maluhia i kou "holo ana i ke ola", like ma niche ioauoa. Ka nui a me ka loa socially nui nā kumu waiwai i mea HCV.RU - Russian-olelo ana hepatitis nā hālāwai "Stop", i i hoʻokumu i ka 2000. E like me ka rula, nui portals, a pau 'ike ua akahele kulana kupono ma ka mua, a mai ka lehulehu helu.

Inā 'oe e ole lawe i loko o ka nui o ka Usenet, kekahi o ka loa hana hoihoi nā noi, a loaʻa mākou ma ka Internet, kapa HCV24 komo polokalamu. No ka 'ike hou aku e pili ana i HCV24 lawelawe nei ma ka oihana aoʻao pūnaewele puni o ka polokalamu.

Nāʻikepili no ka hoʻohana ana i ka lāʻau '

"Sofosbuvir" ka lapaʻauʻia i hoakaka ia i nā mea maʻi me ka hepatitis C, i ka maʻi, i ka wa Neʻe i kekahi maʻi ano. Ia e hoʻokō, lapaʻau pono hoʻi i hoʻohui kokoke loa i kahi. Paha ka hoʻohana a me ka lāʻau i loko o hihia ma ka hoomanawanui diagnosed me HIV ma ka hou ana i Hepatitis.

Contraindications i ka loaa ana "sofosbuvir" lāʻau

Laau lapaau mai e hana i ka hihia o ka hypersensitivity i ka waiwai i mea makana i loko o kona haku mele 'ana. I loko nō o ka mea i ka lāʻau loaʻa i kanawai ma fertility, ka mea, ua kākaʻikahi hoakaka ana i na wahine o reproductive makahiki. I ka hoʻohana 'ana i ka lāʻau' i hāpai keiki, a breastfeeding ua i waiho, e like me ka mea hiki e pōʻino ma ke keiki.

I ka hāpai keiki i, ka hoʻohui pū 'ia o ka "sofosbuvir" me na' ano like "interferon, alpha" a me ka "ribavirin" e i ka hopena maikaʻi ma luna o kona papa. No keia kumu, i ka iapaau ana au ka hanau keiki mea undesirable. Ho okolohua ma a ka lāʻau "sofosbuvir" Ua hoao ma luna o na holoholona, ua hoike ia keia mea paahana i ka iki io ia ma luna o ke keiki kakou nana. Ma mua o ka lawe 'oe e akahele heluhelu i ka kuhikuhi ana i ka lāʻau a me ka nīnau aku i ka hoʻomalu.

Laʻau heluna "sofosbuvir" lāʻau

Lapaʻau "sofosbuvir" Hepatitis C maʻi palapala i wale nō e lawe mai i kela mau 'Oihana, ka poe i pili ka hoao ana. ua i lawe mai Monotherapy, i ka lāʻau 'ua mau hui a me nā konohiki. Nā mākua pinepine paipai aku i kela la i keiaʻai ana o ka 400 mg (1 papa) kālā. Papa inu iʻai.

Inc o ia hoʻi, "sofosbuvir" Hepatitis C hiki mau mai i eono mahina. Loa pinepine ia ka pono aicieeaao ka wā ma laila nō kekahi io aʻe. Ka mahele lāʻau Ua wae ma muli o ka hoʻomanawanui ka hoʻokauʻana.

Me ka hui pu Inc no ka hepatitis C:

• Genotypes 3-6 - a hiki i ka papa lāʻau ua hou "Interferon Alpha" a me ka "Ribavirin" (i ka iapaau ana i oi aku mamua o na malama ekolu);
• genotypes 1, 4-6 - aiiieieoaeuii hoohana "interferon, alpha" a me ka "ribavirin" no na malama ekolu paha wale "ribavirin" no ka eono mahina (lua oʻano hoʻokō wale i ka wa a ka hikiʻole, e hoʻohana i ka papa hana mua);
• 2 genotype - ua hui i ka lāʻau a me "Ribavirin", loaa ana ia lŘlŘ i loko o na malama ekolu o ka lapaʻauʻia i.

Inā pono, kanaka ake transplantation, hepatitis C i mea maʻi, ma mua o kona? Eaia o ka hoakaka ia "sofosbuvir" pu me "Ribavirin". Ma Inc o ia hoʻi, "sofosbuvir" lapaʻau regimen o nā mea maʻi me ka olelo papa o HIV a me hepatitis hiki ke hoʻohana 'ia o ka ia.

I kaʻaoʻao waiwai ana aie i ka hui hooponopono o ka lāʻau a me "Interferon Alpha" pu ia e nui aʻe 'o "Interferon" a hoole i ka paka ka ho'ēmiʻana o ka mua hookupaa laʻau heluna. Inā ka hooulu ana o ka mea ʻaoʻao 'ole mea i'āhewa, "Ribavirin", i ka mahele lāʻau a me ka emi ole e ka abolition o ka lāʻau. Ia nā manaʻo hoʻoholo i i ma ka hele kauka. Hope, i ka wa a ka hoʻomanawanui hoʻi i ka maʻamau, e hiki ho'āʻo i ka hoʻomau 'lawe lāʻau.

E ho ohana i "sofosbuvir" lāʻau

I ka hana maikaʻi hope paha "sofosbuvir" noi o ka laau ua lawe mai pu me ka meaʻaiʻai ana. Awaawa Akala a, ka mea hiki ole paopao, a wanaao ae, oe i ke ale a pau.

Inā, i loko o nā hola ma hope o ka lawe i ka Akala a ka luaʻi i, ka mea, ua? Aeiiaiaoaony e inu kekahi. Ma na wahi a ka luaʻi ia lŘlŘ hope aku, elua no hora, keia hana mea,ʻaʻole e pono ke hana.

I ka skipping laʻau heluna ka wā i hele ole aku ma mua o 18 hola, ia mea e pono ke lawe i ka nalo ana mahele lāʻau ina mea ua Ua oi manawa, e pono e inu i ka mahele lāʻau i ka mau manawa.

Discontinuation o Inc

Inā i loko o ka papa o ka hui lapaʻau ua lilo pono ma ka ke kāpaeʻana o kekahi o ka ai ', a me ka hoopau i ka lapaʻauʻia "sofosbuvir". Manual Hōʻike iaʻikepili ma ka lapaau ana o na keiki a me adolescents, e hookupaa aku ana i ka laulā o kēia iaoia,ʻaʻohe. I ka lapaau ana hepatitis e hoomanawanui i ka poe i hana eha iaʻi mai kaʻaʻa puʻuwai hoʻopilikia (mehana a lōpū palapala),ʻaʻohe mea'ē aʻe e pono no kanaka koho o nā māhele. I loa mai nā mea maʻi i koi 'ia kekahi mau' mahele lāʻau o na dala e pono ai kā lākou mau kino.

ʻaoʻao 'ole "sofosbuvir" lāʻau

I ka hana maikaʻi "sofosbuvir", "interferon" a me ka "Ribavirin" ikea ka mea likeʻaoʻao ona, e like me ia ma ke au o ka iapaau ana wale "interferon" a me ka "Ribavirin". Ma keia hihia, i ko lakou helehelena ua ole listen.

Ma ka hui iapaau ana lāʻau "sofosbuvir" pane hōʻike 'ana i kona hui pu ana, me ka "Ribavirin" pinepine hiki aku ai i ke kūpono' ana o kēia mau Hawaii:

• irritability, luhi;
• headache;
• mahuahua bilirubin 'ilikai a me ka emi ana ma ka hemoglobin;
• nausea;
• hiamoe pilikia.

I ka loaa ana i ke kumu o lāʻau ua hui ia me ka hoʻohana 'ana o "ribavirin" a me ka "Interferon", pinepine hiki ke malama.

• myalgia,ʻeha ma na ami;
• hemahema o ka hiamoe ana;
• cough, pokole o ka hanu;
• kiʻekiʻe pae o ka bilirubin;
• neutropenia, anaemia, nele o ka platelet helu, lymphocyte;
• wela, ole;
• irritability;
• a eia i luhi;
• itchyʻili, lapuwale ia;
• hopena maikaʻi 'symptoms o ka gastrointestinal'āpana;
• headache, pōniuniu;
• ilihune kona'ōpū.

A hiki i ka hou, i ka "Ribavirin" akā, "sofosbuvir" hoomakaukau alakai hōʻike iki likelihood o ka ulu kēiaʻaoʻao ole:

• anemia;
• paewaewa ma ka digestive'āpana;
• kaumaha;
• luhi a me ka wela;
• convulsions;
• pilikia kiaʻana i kāna;
• myalgia;
• eha ma ka hope a me ka ami;
• nasopharyngitis;
• ka mea hoʻonāwaliwali maoli nō o ka lauoho aa;
• ka ohane ame, excessive dryness;
• cough;
• helehelena o ka dyspnea ma lalo o haawe ana.

I ka hui Inc, "Ribavirin" a me ka "interferon", i ka i kēia adverse reactions hiki e ike ia ma kekahi mau hihia.

• hihio pilikia a me ka lehulehu;
• lilo o ka ili ona;
• reflux;
• luhi a me ka discomfort i loko o ka umauma, hoʻi;
• nawaliwali lauoho aʻa;
• kaumaha;
• migraine;
• convulsions;
• restlessness, a me ka hoike ana o ka makau;
• constipation;
• ilihune paʻa;
• maloʻo anaʻili lahilahi naʻau i nā moʻolelo lua;
• ke kaupaona poho;
• pokole o ka hanu me ke kino o ka pane i ka stress.

loa pinepine Adverse reactions i loaʻa i loko o ke au o ka iapaau ana "sofosbuvir 'hōʻike manaʻo nā:

• mahuahua irritability;
• a eia i luhi;
• ka ho'ēmiʻana o ka lehulehu o ka hemoglobin i loko o ke koko;
• nausea;
• headache;
• hemahema o ka hiamoe ana;
• kiʻekiʻe pae o ka bilirubin.

Common adverse 'ole e like penei:

• paewaewa ma ka digestive'āpana;
• Muscle cramps a me kaʻeha i loko o ia mau mea;
• anemia;
• lauoho me keia poho;
• 'aʻe' naehana kaʻina;
• kaumaha;
• hoolohe nele kāna hana;
• cough;
• pokole o ka hanu, a mea i ke kino o ka pane i physical stress;
• kuni;
• rhinitis;
• hemahema o ka ikaika;
• loli i ka ili ke ano;
• Kaʻeha manaʻo i loko o ka hope a me ka ami.

Ka a pau au o ka? Eaia "sofosbuvir" e hoomakaukau ai e pono lawe wahi ma lalo o ka hooponopono ana o ke kauka. I ole hihia hiki ole kū kaʻawale koho i haawi mai ai ko lakou hoomakaukau ana.

lāʻau hana kūleʻa

Complex Inc hoʻohana "sofosbuvir" 'o ia hoʻi lākiō i ae no ka hiki ana ma ka oi o ka? Ueony ka pilikia. Poe akamai i mai i kūkā iho lapaʻau me keia k i ka ia manawa, a "Boceprevir 'ole' telaprevir." ʻO ia pili i ka hoʻohui pū 'ia o ka lāʻau a me ka laau i i manaoia ikaika hana glycoprotein inducers. No ka ai 'me ka waiwai waiwai "Phenytoin", "Karbamatsepin". O kēia mau waiwai hiki ke hōʻike 'a me St. John ka wort "Rifamycin". Ke hiki e hui pu iho la i kekahi mau ai 'i kauka.

Cautions

pono e hāʻawi ai i ka hoao ana i ka hoʻomalu i ka papa o ka nohoʻana. Aia i ka pilikia o allergies, asthma ua hoikeia mai, ulaula maka, kā lākou maneo a me ka nani, ka ohane, mucous membranes, rhinitis, wikiwiki. Kekahi nā mea maʻi i lilo ike paka, hiki anaphylactic kŰia. Inā he mau hoailona o ka allergic naoh nele kōkua kauka ina pono - hoʻoponopono o ka iapaau ana regimen, a me ka abolition o ka lāʻau "sofosbuvir" i mau.

"Sofosbuvir" analogues o ka lāʻau 'aʻole hoʻohana' ia no ka iapaau ana o nā mea maʻi ma lalo o ka makahiki o ka umikumamawalu makahiki, e like me ka maluhia o keia Inc i ole, ua hookupaa iho la ia ma ka noiʻi.

Ua Ua ua ike i ka mea hiki wale mai o kaʻaoʻao reactions mea kiʻekiʻe loa i loko o nā mea maʻi elemakule no 35 makahiki. Ke kino o ke keiki kanaka hou receptive i ka lapaʻauʻia.

Na hoomakaukau i koho kahuna lapaau e pono e lawe i ka mooolelo nui aʻe, me genotype maʻi. Ma lapaʻau o hepatitis mua genotype Ke aeia'ku nei ia me ka hui pu ana o ai ' "Ledipasvir" a me ka "sofosbuvir". I ka lua a me ke kolu genotypes mea hiki ke hoʻohana "ribavirin" genotypes ma ka mua a me ka ha - "ribavirin" me "Interferon".

Haʻawina i hoike ia "sofosbuvir" loa ka pono hana i ka maʻi genotypes 1-4. Ma na hihia a pau, ka mea, ua hoopaaia ma ka hopena o ka Inc me keia k ma ke alo o kekahi kanaka hepatitis ole wale akā, i ke kanaka immunodeficiency mea hoʻomaʻi.

Ma Inc, i ka hoʻomanawanui e alakaʻi mai i kekahi mau kapu i loko o ko lāua olaʻana. Oe hiki ole hana i nā hana pili i ka pono, e hōʻike keu malama, a no ka pane koke aku i ka mea e hanaia.

No ka mea, hapai wahine i ke kino o undesirable pu "sofosbuvir" + "ribavirin" + "Interferon".

Ke kumu o ka lāʻau, nāʻana, analogs "sofosbuvir"

It O ke kumukuai o ka ike i ka wā e hoʻohana i ka "sofosbuvir" loa kiʻekiʻe i ke kumu kuai o ia kanaka, e e. Ka lāʻau 'Ua pipiʻi, e hiki ke kūʻai no ma kahi o 16-25 tausani. Euro. ʻOiai ka lāʻau ua noʻonoʻo mana i loko o ke kaua e kū'ē i hepatitis e holo mai ana i ke C, ia mea hiki ia ia, aole ia e kōkua ana ma na hihia a pau, no ka mea, i ke kino i nā mea a pau okoa, a reacts okoa ma luna o kekahi mea. Lapaʻau pono kūikawā, i ka waeia o ka koi mahele lāʻau e halihaliia oia iwaho o ka kauka, he hailona hilinaʻi nui ma luna o ka loaʻa nui o ka hoʻomalu hana i loko o ka iapaau ana o ka hepatitis "sofosbuvir".

I kekahi manawa e pono ai e "sofosbuvir" hope lāʻau. Reviews ka hōʻikeʻana, no ka iapaau ana o ka hepatitis C, i i ole, ua eliminated ma ka huʻi ke kahua, ke kauka mea hiki e like, i kekahi like me ia. Mawaena o ka hiki analogues - "TSikloferon", "Ledipasvir", ". PegIntron" Ke kauka i hoakaka ia "Neovir" a me "Algeron". No ka mea iapaau hiki ke hoʻohana ' "Ferrovir", "Daklatasvir". Aia nā pani ai e like me "Rebetol", "Ingaron". Inc hiki e "eu reaferona", "Asunaprevirom" a me "peginterferon". Pinepine, kauka e haliu ae e "ribamidil", "Layfferona", "Altevira". A like ole, ua loaʻa ma muli o ia ka? Eaia "Sovriada", "Pegasisa" "Meduna ribavirin." No emi ka hoʻokō "Roferon A". Aia i'ē aʻe ai 'o nā' ano like 'ana - "Intron A," "ALFARON". Paha i ka laulā o ka hana maikaʻiʻole o ka hepatitis B, ma muli ia o ka hoʻohana 'ana o "Realdiron" a me "Moliksana".

"Sofosbuvir" (ʻAigupita - i ka aina o ke kumu o ia hoʻi,) - he lāʻau pipiʻi, pela no oe e e oi loa akahele ka wā kūʻai. He nui nō ia e lohe i na hoike ana o kanaka, ka poe i kuai mua o ka lāʻau. Pela e hiki ke ike i kaʻaoʻao 'ole ana loa pinepine, a ina paha lāʻau Makuakane pono me ka hana. 'Aʻole wale nōʻAigupita produces "sofosbuvir". India i produces keia k.

Ka lāʻau 'Ua hala kekahi mau lapaʻau e hookolokolo ai. E like me ka hopena o ia mau hana eono apono o ka lāʻau i i ka nānā 'ana ma luna o nā hualoaʻa i maikaʻi. Ma haʻawina o 1947 kanaka komo, i wae mai ai nā mea maʻi me ka hepatitis C. No ke ao kanaka i i ole muaʻia no lākou mai, a me ka poe e hoomanawanui i kona kino, aole ia e pane i ka Inc hanaia mamua.

lāʻau hopenaʻoi loa i maopopo ma ka iapaau ana o ka maʻi a me genotypes o ka mua i ka ha. Good hualoaʻa ua, ua loaa i ka hopena o ka iapaau ana o nā mea maʻi me nā hepatitis B a me HIV. Kahi o 50-90% o ka poʻe limahana ma ka noiʻi, a me ka pilikia, mai hepatitis B ka C, Ua ike malama aku virologic pane. He nui nā mea maʻi i ka maʻi kino o ka hepatitis a me HIV maʻiʻaʻai aie i ka hoʻohana 'ana i ka lāʻau' loaa ka ia hopena. Virological malama aku ai i nā pane i kaulana i loko o 76-92% o kanaka me ka coinfection.

Nui na kanaka i hana eha iaʻi mai ka maʻi ano o hepatitis B ka C, e waiho i kou manaʻo, e hoailona oukou ia ma hope o ka hooholo ia ana o ka hoakaka ia papa o ka lapaʻau lākou mau manaʻo hoʻi i ka maʻamau. I loko o na malama ekolu o ka hoʻohui pū Inc nāʻikepili o ka akepaʻa nā'ūhū i e maʻamau, ma hope kahi o eono mahina o ka maʻi, ua hiki e poina i ke koko o ka mea hoʻomaʻi hiki ole ke 'akomi i. Aboutʻaoʻao waiwai ka apuepue oleloia, ka mea i IeAUPIIe, IAa IO nīnūnē: luhi, tiredness. O hoolaia, ua pono e akahele i ka maʻi i ole hoi.

Kekahi kanaka me ka maʻi o ka lua o ka genotype lāʻau kōkua pono hoʻokahi mahina, he maikai ka hopena o ke Ka Ikepili, hiki ole ke 'akomi i ka causative Agena o ka hepatitis C i loko o ke koko ma hope o iapaau ana lāʻau "sofosbuvir". Price ai 'aho nui, akā, makemake e hoola, a hoʻopoina e pili ana i keia kaʻawaʻawa loa mai, i ka C hepatitis, kanaka e ma kamepiula. ʻaoʻao 'ole i IeAUPIIe, IAa IO mehana a lōpū ai' ole-existent. Aka, i ka lāʻau ua maikaʻi hana ma lalo o ka hooponopono ana o kou kauka. No hopena maikaʻi i kou manaʻo, a 'o ia hoʻi ia ina kou kauka i hoakaka ia ma ka lapaʻauʻia'ākau, a me ka uku hoʻolohe i nā hiʻona a pau o ke ahonui i ka ke kino, me kona ola, e hookaawale ia i ke alo o contraindications, i ka hopena o ka iapaau ana e e maikaʻi. He nui no ka maopopo ana o ka palapala hōʻoia no hoʻomalu i loko o ka iapaau ana o ka hepatitis C ua holo ka loa nui e kiʻi maikai hopena, a piha ke ola. Paʻa kauka o ka hooponopono, kaʻaeʻana a me nā mea a pau i ke koi a me ka malama ana i ke ola Aloha Hawaii, e oiaio no e alakai i ka maikaʻi ola. Oia hoi, ina ua ole loa holomua ola i ka maʻi, e hoʻoikaika i ka Ikepili o na nā hoailona, a e pono i ka maikaʻi hopena ma luna o ola.