Ka palapala noi a me ka hopena o "Cefotaxime." "Cefotaxime": he mea like o ka lāʻau

Antibiotic "cefotaxime" - He lāʻau ikaika no ka iapaau ana o infectious maʻi a me ka Kāohiʻana o postoperative complications. Ka lāʻau 'hoʻolauna i loko o ke kino ma ka pahu kui, ka mea, ua pinepine hoakaka no nā mākua a me nā keiki. He He semisynthetic antibiotic me kaʻeleu waiwai sefotaksim paʻakai.

Pharmacological 'ole

"Cefotaxime" - Lunamakaainana cephalosporins, bactericidal hana ua i hōʻoiaʻiʻo aku ma ka suppression o ke kahua o ka halepaahao pā o koʻohune.

Antimicrobial ua manaoia no parenteral ana, ia mea pono ka wā paku ole ia i Gram-io koʻohune mea e hoʻopale ai i nā antibiotics, hiki ke hana i gram-maikaʻi cocci, akā, emi hana ma mua o gram-io koʻohune.

Pharmacokinetics

Ka lāʻau 'Ua hoʻomaka koke paka, ke kaumaha ma muli o ka laʻau heluna mea i loko o ka wai koko o ka elima minuke a me ka hapalua o ka hola ma hope o injecting a malama bactericidal nā hoʻohui like i loko o ke koko no ka oi mamua o 12 hola. Ka lāʻau e komo i ka'aʻaʻa a me ka loli, pono puunaue i loko o ia mau mea. Wā hoʻohana 'ia i loko o lactation lapaau ke kiʻi i loko o ka umauma o ka waiu. ʻO kā mākou ia "Cefotaxime" ua loaʻa ka wā pono nā hoʻohui like i loko o ka synovial, peritoneal a me pleural fluids. Derivation ua hana ua hoʻololiʻia ma ka mimi (ma kahi o 60%), a ma ke ano o metabolites. No ka hapa-ola i ka hopena o ka V / ka m, a / ma ka koi 'ia 1 HR.

Nāʻikepili no ka hoʻohana ana i ka medicament

Nāʻikepili no ka hoʻohana ai 'i infectious ano o ka li nui hoʻonāukiuki e anakahi iki-meaola i mea okoa sensitivities e "cefotaxime" (ʻano nui gram-io). Hoopukaia wale o ia hoʻi, no ka injections "Cefotaxime" analogs ma ka papa loaʻa, ua hoʻohana 'ia ka lāʻau i loko o nä ia Hawaii:

• maʻiʻaʻai ka heluna o ka abdominal lua;
• lesions o kaʻili, ami,ʻaeʻae'aʻaʻa a me ka iwi;
• nā mea palahēhē o ka naehana'āpana, ihu, puʻu, pepeiao;
• maʻiʻaʻai ka heluna o ka urinary oihana;
• Lyme maʻi;
• hoʻoʻino keʻano o ka hanaʻana o infectious ano i loko o ka pelvic nā loko, gonorrhea;
• 'ā, mailoko oʻeha;
• meningitis, endocarditis, septicemia;
• nā mea palahēhē o immunocompromised;
• Kāohiʻana o infectious maʻi ma hope oʻoki lāʻau lapaʻau ke kaʻina hana (ana ma luna o ka gastrointestinal'āpana nā loko, a me ka obstetric gynecological a me ka urological kaʻina hana).

Contraindications

"Cefotaxime" analogues ma na injections i kekahi contraindications e pono e manaoia mamua i ka hooponopono ana o ka lāʻau.

Ka lāʻau 'Ua contraindicated ma ka hihia o ka hypersensitivity i penicillins, carbapenems a me nā cephalosporins. Kona pono hoakaka no ka ake a me nā konāhua maʻi, ulcerative colitis, lactation. Hapai na wahine i hoakaka ia wale nō inā he mea he nui kamepiula a hiki i ka fetus a me ka makuwahine o ke kino, manao iho la e pono ai me ka nui loa ma mua o ka hiki ka pilikia. Wā hoʻohana 'ia ma ka pili ana i na keiki ma lalo o ka makahiki o 2,5 makahiki,ʻaʻole ae e hoʻohana i ke ano o intramuscular ka pahu kui.

E ho ohana ana i ka lāʻau, laʻau heluna

E ike pehea e Kamakawiwo Ole "cefotaxime", ia mea pono e heluhelu i ka ike hāʻawiʻia i loko o ka'ōlelo aʻo no ka hoʻohanaʻana i ka lāʻau. Ka lapaʻauʻia manaoia no ka i / m + a / ma ka hoʻokomo 'ia' (i kekahi dropper a bolus).

Ka lāʻau 'ua hoakaka ia no nā mea maʻi mua o 12 makahiki, i ka wa a ke kino kaumaha, ua oi aku ma mua o 50 kilograms:

• infectious maʻi o ka urinary'āpana, a ma ia mau hihia, i ka wa o ka maʻiʻaʻai ia lŘlŘ ole complications meaola ma kekahi papa hana i loaʻa i 1 g. o ka hoʻomākaukau i nāʻanuʻu o ka 8-12 hola;
• uncomplicated huʻi gonorrhea ano lawelawe singly ma ka intramuscular ala 1 g. o ka lāʻau;
• hoʻohana 'ana i ka lāʻau no ka iapaau ana o ka infectious ano, ka oolea o ka i mea ka awelika, ma kekahi hiki ala e hoʻolauna 1-2 g. o ia hoʻi, i ka manawa i 12 hola (ma mua o ka oki mare "cefotaxime", ia mea pono e akahele hoʻopaʻa haʻawina i ka rula e a he makaukau pāʻoihana no ka pahu kui) ;
• ikaika i hana nā mea palahēhē, e laʻa me, meningitis, e noi mai ana i ka hoʻokomo 'ia' i loko o ka aa koko 2 g. o ka lāʻau maʻanuʻu o ka 4-8 hora, a me ka mea i kā mākou mahele lāʻau no ka lā e e ole oi mamua o 12 g.; lōʻihi like 'ole o ka hana me ka nānā' ana i ka oolea o keʻano;
• mua ana i anesthesia, e hoʻopau i ka likelihood o ka maʻiʻaʻai ua lawelawe 1 g. o ka lāʻau, i loko o kekahi mau hihia 6-12 hola ua lawe reintroduction 'o ia hoʻi;
• cesarean pauku ua hana e 1 g. o "Cefotaxime" hope i ke kaʻina hana ua hai i hoʻolaunaʻia ma.

Ka lāʻau 'Ua hoi hoʻohana intravenously i pili i premature keiki a me nā pēpē i:

• makahiki, ua emi mai o 1 hebedoma - hoʻohana 50 mg no 1 kg o ke kino ke kaupaonaʻana me ke alapine (frequency) 12 hola;
• makahiki o ka 1 i 4 hebedoma - 50 mg no 1 kg o ke kino ke kaupaonaʻana me ka periodicity o 8 hola.

Keiki ka mea kaupaona emi o 50 kilograms ma ka makahiki o 2,5 makahiki, e hoonoho 4-6 Introduction One o ka hiki ano o 50-180 mg no kilogram o ke kino ke kaupaonaʻana (e e maopopo like "cefotaxime" ole novocaine, oe e heluhelu i ka olelo akahele) . Inā he mea he nui papa o ka maʻi, hoʻohana a 100-200 mg / kg. I ka lā i oluolu i 12 g. O ka lāʻau.

Makaukau o nā pāʻoihana no ka pahu kui

intravenous ka pahu kui

Ke sterile ka wai no ka pahu kui (4 ml) Ua nāu kekahi me ka 1 g. O ka lāʻau. Ka pāʻoihana Ua lawelawe ma 3-5 minuke, ia mea nui ia i ka lohi hānau i loko o ke kino.

Intravenous infusion (drip)

Ma 50-100 ML o'ūheheʻe (dextrose 5% a me ka paʻakai koloriside 0,9% la) nāu kekahi 1-2 g. O ka lāʻau a me ka infusion ua lawe mai no 50-60 minuke.

intramuscular

I 4 ml o ka pāʻoihana (1% novocaine pāʻoihana -th, wai no ka pahu kui) lawe 1 g. O ka lāʻau, e injections ma na lākou kīkala, ke kui kele ma e komo nui i loko o ka Muscle.

Hoʻokō 'ana i ka lapaʻauʻia kauoha hoʻohana

no ka mea, ua loaʻa "Cefotaxime" analogues i loko o na papa, noi i loko o kaʻaeʻana me ka ho'ākāka 'ia i ao. Mua ana i ka ka lapaʻauʻia pono, e hookaawale i ka likelihood o allergies. E hoomanawanui i ka poe i hiki ia i allergic naoh i ka penicillin, e e hoʻohana i ka lāʻau me ka lōʻihi mālama nui. Inā he mea pā lonoaʻili i ka waiwai i loaʻa ma loko o ka lāʻau lapaʻau huina hoonui, kona hoʻohana ua hoʻi i kāpiliʻia. Ma ka iapaau ana o ka oi mamua o 10 mau lā pono papa'āweʻaweʻa kemika nana ana iʻike ākea koko holo. E hoʻopau undesirable reactions i lapaau pono, e haawi aku i ka waiʻona.

Overdosingʻaoʻao waiwai

"Cefotaxime" analogues i loko o ka wehe i ka nui helu o kaʻaoʻao ole:

• allergic reactions (urticaria, ka ohane, poʻe noʻonoʻoʻole, kuni, ole, bronchospasm, anafillaksiya, eosinophilia, angioedema, ʻawahia epidermal necrolysis a me Stevens-Johnson);
• dyspepsia (ʻeha i loko o ka abdomen, dysbacteriosis, flatulence, nausea, ka luaʻi, constipation a diarrhea, kāna hana o ke akepaa, me ka pohihihi keia hihia - pseudomembranous colitis);
• glossitis, stomatitis;
• haunaele ma ka hematopoiesis'ōnaehana (hypocoagulation, hemolytic anaemia, thrombocytopenia, granulocytopenia, neutropenia, leukopenia);
• abnormalities ma ka urinary nā loko (interstitial nephritis, anuria, oliguria, azotemia, kiʻekiʻe pae o ka urea i loko o ke koko);
• pōniuniu, headache;
• hopena maikaʻi 'keʻano o ka hanaʻana i loko o ka mea'ōnaehana mānowai koko'ōnaehana (arrhythmias e hali ana i kekahi ikehu hoʻoweliweli' ana i ke ola);
• undesirable i nā reactions (infiltrate, ola / m, phlebitis);
• loli ma ka keʻena hoʻokolohua kiko'î (wahahee maikaʻi Coombs 'ho'āʻo);
• superinfection (ku una candidiasis, candida vaginitis).

"Cefotaxime" mea like o ka lāʻau 'ia ka wā i loko o nā māhele kiʻekiʻe ke alakai i ka overdose, i ukali ia e convulsions a me nā symptoms, iwaena o lakou - o ka nui, tremors, encephalopathy (loa pinepine keia symptom ua mālama i nā mea maʻi e loaa ana mai kaʻaʻa puʻuwai ole). E hoʻopau i ka hopena o ka overdose symptomatic kanaka ua hoʻohana 'ia.

Uluwehi O AaOIeIOUIeXAOAaIN me nā lapaʻauʻia

Inā 'oe pono e' imi i ka mea a me ka haku mele i 'ano like me ka haku mele' ana o na dala i "cefotaxime" mea like kaʻohiʻana i e e pilikia. Akā,ʻaʻohe mea, me ke kōkua o ka lāʻau Inc ua hana ka hoʻohana 'ana i ka palapala mea like paha, ma kekahi hihia, e pono e lawe i loko, no ka AaOIeIOUIeXAOAaIN o ka lāʻau a me nā lāʻau.

I ka "cefotaxime" Ua pili nā palena papaha i nephrotoxic ai 'e like me furosemide, aminoglycoside antibiotics, ka mea, he pono e malama i ka hana o nā puʻupaʻa, no ka mea, no ka pilikia o nephrotic hopena.

No ka iapaau ana o ka maʻi he nui, a ole ai i ko lakou ulu pinepine hoʻohana "cefotaxime". Na Ke Kumu no ka hoʻohana 'ana, ua e e? Anoee lāʻau' analogues, e like me keia mea paahana hiki i allergies, i ka hailona o kaʻaoʻao 'ole a me nā hiʻona. hiki ole e hoʻohana 'ia nā pāʻoihana o ka lāʻau i loko o ka huipūʻana me nā pāʻoihana o antibiotics, ka mea hiki ole e pili ana i ka drip keena, a me ka' ohe.

analogs

O ia hoʻi, no ka "cefotaxime" Analog pono e koho no kaʻeleu waiwai. Mall analogues hiki ke hōʻike ':

• cefotaxime paʻakai;
• cefotaxime hue, Sandoz, paʻakai a me ka lek;
• tsefosin;
• tsefantral;
• tsefabol;
• tsetaks;
• tirotaks;
• tartsefoksim;
• taltsef;
• auhau-i-ke uwe;
• spirozin;
• rezibelakta;
• oritaksim;
• oritaks;
• liforan;
• klafotaksim;
• klaforan;
• klafobrin;
• kefoteks;
• intrataksim.

No ka mea, he ākea huahelu o ka mea paahana no ka la hoomalolo "cefotaxime" Analog koho oluolu, akā, na, no, ka analogs ke i nāʻaoʻao waiwai, a me kā lākou hoola ole paha e hemahema, ke kūapoʻana i ka palapala lāʻau e e koho loa akahele. E pale undesirable hopena, e aʻo i ka 'ike e pili ana ai' e i? Aaony ia e hoʻohana.