"Kardosal": Na Ke Kumu no ka ho ohana, nāʻana, wehewehena, analogs

"Kardosal" (lahui inoa - "olmesartan medoxomil") mea he hoa o ka angiotensin II mea loaʻa ( 'ano AT1) - iniiaiie vasoactive hōmona RAAS e pili ana i ka hooulu ana o ka nui hypertension.

Palapala hookuu aku i ka lāʻau, kona eiiiiiaiou

Ka lāʻau 'Ua loaʻa ma ka papa i uhi ia e ka wahi. XIX. Waiwai, no ka mea, a he medicament o olmesartan medoxomil ia i loko o ka papa loaʻa mai ka 10 a hiki i 40 mg ( "Kardosal 10", "20 Kardosal", "Kardosal 40").

Eia kekahi, o ka lāʻau i huiia makanekiuma stearate, microcrystalline kelulose, lactose monohydrate. Nō hoʻi, e like me kākoʻo koponentov hoʻohana giproloza a me ka haahaa hookomoia giproloza. Ka iwi Ua hana mai titanium'okikene lua me i hoʻohuiʻia talc a me ka hypromellose.

Pharmacological 'ole

Ua Ua ea ae ka hana i ka lāʻau "Kardosal" e hana ma luna o ka meaola, ka poʻea pau i ka paleʻana i ka hopena o ka angiotensin II, _AT1 mea loaʻa mediated. I hypertension medicament emi arterial puʻe, ua like me ia mau mea i ka lōʻihi manawa. 'Aʻohe' ikepili e hookupaa aku ana i ka hanana o hypotension ma hope o ka hana mua o ka loiloi mua mahele lāʻau o ka lāʻau a me ka tachycardia ma muli o ka loa-makahiki Inc ( "Kardosal 20", "Kardosal 40"), i keʻano o ka withdrawal pu ma kahi nihinihi hiki mahuahua i loko o ke koko,.

I ka hoʻohana 'ana i ka lāʻau, hoʻokahi nō ka lā i nā hualoaʻa ma ka mehana emi i loko o ke koko, nā hoailona. Ka makemake ole e hoʻomōhala ana i luna o 24 hola. Nō kāu, ka hypotensive ia ua loaʻa i ka lāʻumikumamāhā o ka lapaau, i ka maikai hualoaʻa i malama ma hope o lapaʻau o ma kahi o elua mahina.

Pharmacokinetics

Ke omo o ka lāʻau, kona hoi o ka makana

Inu i ka papa hoʻomaka koke i ka palapala o ka pharmacologicallyʻeleu metabolite i loko o ka naʻau liʻiliʻi (ma muli o ia i ka hana mana a ma nā'ūhū) a me ka puka koko (i omo mai ka gastrointestinal'āpana).

Iloko o ka pākōlea haku mele 'ana o ke koko wai koko ua ole' akomi iʻeleu waiwai ua hoʻololiʻia. Ka bioavailability mea ma kahi o 26%. ʻO kā mākou kiʻekiʻe o ka lāʻau i loaʻa i loko o ka awelika o ka, elua no hora hope lawe ia, me ka mahuahua laʻau heluna (hookahi mahele lāʻau - 80 mg) o ka mea maoli.

"Kardosal 40", e like me huahana me kekahi laʻau heluna o kaʻeleu 'Oponopono, hiki ke laweʻia me hoʻomālama ma kaʻai hokii. Aiʻaneʻane i kanawai ma bioavailability.

E pili ana me ka wai koko kumuʻiʻo Ua kokoke loa, a me ka hoʻopili like ia 99,7%. Naʻe, ka mea i ka wā hoʻokahi pono "Kardosala" vysokosvyazyvayuschimisya me nā ai 'ia ua kūpono kou hoemiia.

Uluwehi O pūnao a me kona excretion mai i ke kino

Holo nōhie lāʻau loko ake (60%), i ke koena (40%) - puʻupaʻaʻelua. Intrahepatic holo o ka hana waiwai ka mailuilu haalele. Mai excretion ua hua maiʻano nui ma ke akepaʻa, me nā hana maikaʻiʻole konohiki "Kardosal hua hoʻohui" ka mea, ua papa ia ina ka hoʻomanawanui i biliary'āpana iaʻi. Ma hope iho o ka puana 'ana o ka lapaʻauʻia hapa' ia e hōʻike 'ia ma luna o ka awelika no ka 12 hola. Good hopena ua malamaia ma luna o ka loaa ana i ka laʻau heluna o ka lāʻau, a hoʻopili like i kekahi mau nā māhele o ka "Kardosala". A nui ai ka makana, a ma hope o umikumamaha lā o ka lapaʻau, i hoakaka ia hoʻomāhuahua 'aʻole i kānāwai. Ma keia huahelu, e like me kaʻaʻa puʻuwaiʻae ua ole loli ana ma kekahi lāʻau laʻau heluna, ia mea ma ka laulā o ka mai 0.5 hiki i 0,7 L / h (ka hola).

Special lapaʻau hihia

O na e hoomanawanui i ka poe i loaʻa ma ka 'aʻe' ana iʻaʻa puʻuwai hana (mehana, lōpū, loa), AUC mahuahua ma ka 62, 82 a me 179%, ka wā i ke ano ka hale lio.

I ka akepaa pilikia, iki, a moderately i olelo ia, hookahi mahele lāʻau AUC mahuahua mea kōkua i 6 a me 65%.

hoike

Ka manawa o ia hoʻi, "Kardosal" aʻo ma ka noi mau hiʻohiʻona nō ka loaʻaʻana o ka nui hypertension.

Malamaia lakou nei, "Kardosalom" i hāpai keiki mea unacceptable. Inā ka hāpai keiki i loko o ka iapaau ana kaʻina, ia mea e pono ia e ka abolition o ka lāʻau.

Ma muli o ka nele o nāʻikepili kākoʻo i ka maluhia o ka iapaau ana o ka umauma, e ai ana i ka manawa o ka iapaau ana ho'ōki breastfeeding.

Ia e hiki ke kūʻai "Kardosal" a hoʻomaka me ia ia e hana, i ke kauka e kākau i kekahi kuhikuhi.

Contraindications

Contraindications nā hypersensitivity i ua mau waiwai a pau i komo i loko o ka hoʻomanaʻo, keiki (ma lalo makahiki 18), hāpai keiki, umauma-e ai ana. Eia hou, i ka Akala a ua i koi 'ia ma ka kēia hihia.

• iaʻi o ka biliary'āpana;
• i ke alo o ka malabsorption maʻi pale, galactosemia;
• hemahema o ka lactase;
• manawa ma hope o ka hakuʻala transplant;
• ʻaʻa puʻuwai ole ma haʻahaʻa QC (emi o 20 ml / min).

"Kardosal" - he lāʻau i ua lawelawe me ka lōʻihi mālama nui i nā mea maʻi i ana:

• coronary artery maʻi;
• hyperaldosteronism (iniiaiie);
• kāna hana o ke ake;
• ʻaʻa puʻuwai ole, ma a KK mea oi aku mamua o 20 ml / min;
• stenosis, lesion pu ma ka mitral a aortic kiwikā;
• maʻi naʻau ole pele;
• cerebrovascular maʻi;
• ʻai pu e kaupalena paʻakaiʻai ana;
• hyponatremia, hyperkalemia (ʻaʻohe mea he pilikia o kaʻaʻa puʻuwai insufficiency, hypotension paha dehydration);
• moku'āina ka wā bcc emi hou ka luaʻi, diarrhea;
• stenosis, hitting ka artery wale hakuʻala,ʻeluaʻaoʻao stenosis, ma i ka loli ana oʻaʻa puʻuwai artery;
• hypertrophic obstructive cardiomyopathy;
• makahiki no 65 makahiki;
• i ka pono no ka diuretics.

E ho ohana i "Kardosala"

"Kardosal" manual ia kekahi hoʻohana 10 mg, a hoʻopili like ai i ka loiloi mua mahele lāʻau. I ka lawa ke koko, normalization no lā mea pono e hana 20 mg o ka lāʻau. Oi mahele lāʻau o 40 mg lāʻau no ka lā mea unacceptable. Kela la i keia ka lapaʻauʻia e inu i kekahi manawa, ma kekahi a me na ia manawa. No nā mea maʻi hakuʻala pilikia me hoikeia mehana e hoʻokanahaʻi oolea, ka wā o kaʻae mea i loko o ka laulā o ka mai 20 a hiki i 60 ml / min, i ka i kā mākou mahele lāʻau "Kardosala"ʻaʻole e hiki oi ma mua o 20 mg. Ma na wahi he mea i pono, e hooikaika i ka kūpono hookoia ua hua mai la i luna 'lapaʻau (koe wale no "Kardosala" pili "Hydrochlorothiazide").

ʻaoʻao waiwai

Ma ka hana maikaʻi i ka lāʻau ' "Kardosal" manual ae iaʻaoʻao ole:

• hopena maikaʻi naoh mai ka ÷ naehana hanu a me ka digestive nenoai, i ke ano o ka haunaele ma ka musculoskeletal'ōnaehana, urinary'āpana a me nā konāhuaʻelua, hoʻololi kekahi keʻena hoʻokolohua kiko'î, ka hooulu ana o kekahi mauʻano kāna hana (e likeʻaoʻao 'ole i hoʻomaka ai pinepine);
• ulu o angina, i keʻano o kāna hana ka heluna i ka'emi'ōnaehana (kekahi manawa hou);
• hoʻololi i ka mea'ōnaehana mānowai koko'ōnaehana, i ka ulu ana o ka hyperkalemia (kākaʻikahi ike).

ʻaoʻao waiwai e ala mai loa kākaʻikahi ma hope o ka loaa ana medicament "Kardosal" kauoha no ka hoʻohana nā:

• haunaele ma ka hematopoietic oihana;
• cough;
• huʻi ano o kaʻaʻa puʻuwai ole;
• ili pilikia;
• asthenic maʻi pale;
• headache, pōniuniu helehelena;
• myalgia;
• convulsive moku'āina;
• nausea pu ma ka luaʻi, abdominal eha;
• mahuahua ana o ka urea, creatinine i loko o ke koko;
• loli i ake - mahuahua ma ka hope o kona nā'ūhū.

overdose

Overdose mea hiki, e hoike mai ai ia i na hiohiona ka ho'ēmiʻana o ke koko, nā hoailona. Ma ka hihia o ia i ka hopena o ka hana pono ai ka pololei, ka mālamaʻana o nā mea maʻi. E hoʻopau i ka symptoms e pili ana i ke overdose o ia hoʻi, "Kardosal", kauka paipai aku ia oe hana hōʻike manaʻo symptomatic lapaau, a ma hope Inc e normalize ke koko. I Ina o overdose kau i ka hoʻomanawanui ma luna o kona kua, a e hapai i kona mau wawae. Eia hou, i ka wa a ka hoʻohana 'ana i ka nui mahele lāʻau o ka lāʻau ua? Aeiiaiaoaony e hana gastric lavage, e haawi mai i ke kanaka ho'ā' kalapona. Aia He He pono no ka leo hope, hoʻopau o ka dehydration a me ka hoihoi hou ia ana o ka wai-paakai koena. Information e pili ana i ka manawa kūpono o ka excretion o ka waiwai olmesartan medoxomil ma dialysis malaila.

Cautions

Ma nā mea maʻi i mua o ka Inc intensively ia me diuretics, a hahai ma hope o kaʻai i ka neʻe aku o ka hoopau ana o ka paʻakai, e i hypotension like me ka hopena o ka mua mahele lāʻau i o ka lāʻau. Na ia mau hopena hiki ke malama i ka hoʻomanawanui iki mai ka poe i hana ka luaʻi paha diarrhea. Ke kumu no keia naoh o ke kino - ka ho'ēmiʻana o BCC. Adverse hanana o keia ano e e Hāʻule maila lākou. I ka pilikia o kona hanana E e noʻonoʻo mua hoʻomaka Inc.

Inā he kanaka ua uhaʻiʻia nā puʻupaʻa, ia mea nui i kekahi manawa ka huli mau kii, he lāʻau lapaʻau like creatinine, potasiuma. Ka hoʻohana a ACE nā mea kūpale e hoʻomanawanui iki mai ka poe i ua diagnosed hyperaldosteronism (iniiaiie), mea meaningless, no laila, ka mea e ole i hoakaka iaʻano "Kardosal" (lākiō i hōʻike i pane i ACE nā mea kūpale).

E hoʻomanaʻoʻoukou i ka ikaika emi i loko o ke koko, i loko o nā mea maʻi me ka atherosclerosis, i loli ai ka ipu lolo, a me ka coronary artery maʻi hiki i ka hooulu ana o ka pilikia olelo e like me ischemic hahauʻana a me ka myocardial infarction.

Inā ke kanaka e hana hoomau o technically luna 'hana a kipaku i ke kaa, ia mea nui i ka ike i ka lawe "Kardosala" hiki i kekahi mea hōʻemi o ke ola (luhi, nawaliwali, vertigo), eia nae keia kākaʻikahi hana.

Aie i ka mea lactose ka maʻiʻo ma ka lāʻau lawe ia i papaia, e hoʻomanawanui iki mai me ka hereditary galactose intolerance külana. ʻO ia pili i nā mea maʻi me ka malabsorption maʻi pale galactose a me ka monakō koko, lactase deficiency i loko o ke kino.

AaOIeIOUIeXAOAaIN me nā ai '

Ke kauka Pono e kākau i kekahi kuhikuhi, a loaʻa mai ina ka hoʻomanawanui ua malamaia lakou nei, e kūpale 'ia e, e ole hua'ōlelo i makemake reactions. Ua UaʻAʻole pono e hoʻohana nā "Kardosalom" a me ka hahai ana i ke ano o ka ai '.

• o ia hoʻi, i loaʻa potasiuma;
• paakai ae pani ai, i loaʻa mau o ka potasiuma mea i hiki mai;
• Potasiuma-loa lakou e minamina diuretics;
• lapaʻauʻia i aloha ia potasiuma pae i loko o ke koko lāʻau lapaʻau (mahuahua keia huahelu).

An kumu o iaʻano o ka "Heparin". He hiki ke ho ololi i ka maʻiʻo o potasiuma i loko o ke koko. At impossibility o ka lapaʻau "Kardosal" analogues i ka manawa, e hana i kona hope.

Hoʻoikaika 'ana i ka antihypertensive hookoia ua malama ia ka lapaau ana o ka antihypertensive ai' 'ē aʻe, a NSAIDs, oa i ka manaʻo o nā hulina lapaau. Inc me ka noniakahi hoʻokokoke komo ai i ka hoʻohana 'ana o Punk-2 nā mea kūpale, acetylsalicylicʻakika (kela la i keia mahele lāʻau - oi ma mua o 3 g). I ka hana o ka angiotensin II mea loaʻa hakaka hiki e synergistically i alakaʻi ai i ka glomerular kānana ma kona ka ho'ēmiʻana.

Me ka i ka wā hoʻokahi 'ana o ia mau medicaments me angiotensin II mea loaʻa hakaka, a me NSAIDs, aia no he likelihood o ka hoʻomanawanui ka huʻiʻaʻa puʻuwai ole shape. No keia kumu, ka mālamaʻana o kaʻaʻa puʻuwai kūlana ma ka loiloi mua kahua o ka lapaʻau E e hana mau. Oia lapaʻau E maopopo leʻa inu lawa fluids. Naʻe, ka mea hiki ka ho'ēmiʻana i loko o ka oolea o antihypertensive hana, a ma mea hōʻemi ua malama pinepine laulā o ka Inc.

Inā "Kardosal" ua hoʻohana 'ia i loko o ka iapaau ana au antacids, o Aluminum hydroxide a me ka makanekiuma, aia no he kamepiula ka ho'ēmiʻana i loko o ka bioavailability o kaʻeleu waiwai (lōpū).

Ua hoike reversible, piʻi pū likiuma pae i loko o ke koko lāʻau lapaʻau a me ka hōʻike 'ana iʻawahia waiwai mai ana i ke kaʻana o ACE nā mea kūpale, angiotensin II mea loaʻa hakaka a me ka ai' i loaʻa likiuma. I ka pili ana me ka hui pu ana, Inc kākau'ōlelo "Kardosalom" a me ka ai ', kekahi o i eiiiiiaiou - likiuma,ʻaʻole paipai. Eia naʻe, ina ia he mea e pono ole, hooponopono o ke koko e e mau.

Ke kāki o ka ai ', analogs, hōʻike manaʻo

I ka ka lanakila "Kardosal" na papa e like me ka kumukuai mea,ʻaʻole i nā nā mea maʻi, no laila, ka mea, e hoihoi i loko o ka manawa kūpono o ka lapaau ana me ka hoʻohana 'ana o kekahi, oi ka hoʻokō' ana. "Kardosal" me ka maʻiʻo o ka 10 mg o ka hana 'Oponopono hiki ke kuai no ka hamo i 610, i ka lāʻau no a ka haku mele i 20 mg oʻeleu' Oponopono -. Over 756 hamo i. "Kardosal", nona kumukuai mea e pili ana 860 rubles., He 40 mg o ka papa kuhikuhiE ke keʻena.

Ma ka analogy, ka wā 'oe i ke koho' ē aʻe mea, e hoʻokō Inc, kahi o "Kardosala" oe ke pili i ka lapaau "Olimestra" a paka i kekahi hui malu pu ana Inc ma muli o ka hana o ka "hydrochlorothiazide", "olmesartan medoxomil". 'Oe ke lawe ka lanakila o na analogs me "Lozarel' ole 'Cozaar'. A, no ka mea, o ka hope o ke kupono ai ' "Nortivan" "Valsartan Zentiva".

Ike o na mea haʻilula keimikala me "Olmesar", "Plaunak". IeAUPIIe, IAa IO ae pani ai oko mai o ka palapala dala, kekahi o na oko mea kupono kumukuai, a hoemiia bioavailability kiko'î a, no laila, ka mea i emi mai kona mana, eia nae ka mea hiki ke Makuakane me ka hana.

mea mau hoʻohana 'ia ma lalo o ka ikaika nā limahana o ka hoʻomalu Analogs, ia mea pono, e mau ka huli ke koko. Inā 'oe pono e lawe ia i mea like me ka hale "Kardosal" ma mua o puku i keia k, ke kauka hoʻoholo, e lawe i ka mooolelo o kaʻokoʻa ka manawa ihola. Ma ka loaʻaʻana o ka adverse hanana i ka lapaau au i ka mea like e lilo ia e hana i ka mea hana i loko o ka 'eleu kūpono pahuna ma kā lākou hoʻopau. Ma lapaʻau ia mea e pono, e kaha i ka hopena ma luna o ke kino.

A hiki aku ka palapala me ka hoʻololi 'ana i na mea paahana, hiki ole ke hana, e haawi aku ana kāu mau koho ia ai' ua hanaʻia maʻEulopa poʻe ho'āʻo. I ka hoʻolalaʻo e puku "Kardosal" papa analogues oe wale i ke koho i ka lani kiekie loa e like ai.

Comments haʻalele i ke kauka-ahonui Usenet, e hōʻike i ka lāʻau "Kardosal" i lapaau pinepine ke kumu no adverse reactions, ka loa, he pono ole o ka a - ka pahu eha a me ka ikaika aku luhi. Akā, mamua mau kaʻawaʻawa loa minute, ka hypotensive ia ka manawa maikaʻi loa. Helehelena o adverse 'ole pono kōkua i ka hoʻomalu no ka'ōlelo aʻo, a me ke hoʻololi i ka iapaau ana regimen.

Ma ka iapaau ana o nā mea maʻi me ka arterial hypertension i hoikeia, ia mea pono i ke ahonui o ka paʻa 'ana. Manaʻo o ka Inc, pela e hoʻolako i ka makemake kanawai, a me ka hahai i ka moku'āina o ka meaola, a ma ka hihia o ka 'aʻe' - e koho ia i ka manawa. Nui noniakahi hookokoke, akā, lāʻau lapaʻau mea,ʻaʻole lawa, ua pono no hoi koho i kekahi kupaianaha meaʻai. Mawaena o na koi iapaau ana kūlana - kaʻaeʻana akahai pololei o ka hana, Kaniak hoopakele ia o ka maikaʻiʻoleʻano me, kali physical hana a me kaʻaeʻana i nā aha hookolokolo i i ua manaoia no ke kauka i ka maikaʻi loa iapaau ana i nā hualoaʻa.