Lapaʻau "sofosbuvir": hōʻike manaʻo. "Sofosbuvir" + "Daklatasvir": hōʻike manaʻo hoʻomalu. "Sofosbuvir": i ke aʻo o nā kauka hōʻike manaʻo

Ke ake nei keʻano o ka huikala Kānana no ke kanaka kino. Ano o ke kino e loli ai ka functioning o na mea he nui nenoai, a me ka pono o ke kanaka ola i loko o mau. Kekahi o ka loa mea akepaʻa ua manaoia e e hepatitis C. I ka keia manawa, e hana me ka maʻi ulu i ka hailona o ka ai '. Kekahi o ka loa ka hoʻokō hana ua noʻonoʻo (i ua hookupaa iho la ia ma ka 'inikua hōʻike manaʻo) "sofosbuvir".

Nāʻikepili no ka hoʻohana

Nui sofosbuvir ka mea, kapaʻeleu 'Oponopono i loko o ka papa, a me ka hao iho i ka oihana inoa "Sovaldi". Pela, e mea hiki ke olelo aku i keia ka lapaʻauʻia ho'ēmi ae pani - nōhie "sofosbuvir" i hōʻike manaʻo wehewehe i ka lāʻau 'me kekahi o ka loa ka hoʻokō ai' no ka iapaau ana o ka hepatitis C. kēia mea i kona papa kuhikuhiE wahi o ka palapala noi.

Baseʻia - sofosbuvir - mea he inhibitor o ka NS5B mea hoʻomaʻi polymerase, 'o ia hoʻi, inhibits mea hoʻomaʻi replication kaʻina - .. Ka causative Agena o ka hepatitis C. naʻe, loa' inikua kilo'ōlelo mai e waiho aku monotherapy "sofosbuvir" (naʻe ia mea i loko o loina hooponopono hiki). Akā, e like me ka papa kuhikuhi hana ke keʻena o ka luna 'Inc o antiviral lāʻau "sofosbuvir" pane ka mea i wale nō o ka maikaʻi kuhikuhi, characterizing ia me he lahui ka hoʻokō' ana. E like me ka hana lapaʻau haʻawina, me ka lāʻau i loko o tandem me nā ai 'hōʻike maikaʻi loa i nā hualoaʻa ma ka iapaau ana o ka hepatitis C (genotypes 1, 2, 3).

Lapaʻau "sofosbuvir" ola ka poe e hana i ka maikaʻi i kou manaʻo,ʻaʻole wale no ia, aole loaʻia nā mea maʻi, akā, no hoi no ka poe i loaa mamua Inc me nā antiviral ai ', a ma ka hope o ka hana maikaʻiʻole ma hope o ka manawa, e kiʻi i kekahi relapse.

Ma waho o ka luna-i ho'ākāka 'ia wahi o ke keiki, "sofosbuvir' hōʻike manaʻo a me nā koi o nā kumu aʻo ae i ka hana i loko o ka iapaau ana o nā mea maʻi e loaa ana mai ka cirrhosis o ke akepaʻa.

E pili ana i ka laulā o ka lāʻau e ku e HIV a me ke kākoʻo 'hepatitis-maʻiʻaʻai (he' ano, he pono ole kulana home 'ole), i kēia' ike mea a ianoiyuaa aʻaʻole i loaʻa, eia nae o ka lāʻau ua hōʻike no ka hoʻohana i loko o ia mau wahi, i hiki.

Contraindications

Ma ka hapanui o na hihia, i ka lāʻau ia iho a me kona nōhie ai 'ua pono tolerated e hoʻomanawanui iki mai.

Eia naʻe medicament no ka iapaau ana o ka hepatitis C "Sovaldi" ( 'ole "sofosbuvir") pane i nā maikaʻi kuhikuhi, e like me kekahi laekahi nui efficient medicament, he contraindications no kekahi mau noi.

Mua, keia kanaka hypersensitivity i ka papa kuhikuhi, a kākoʻo eiiiiiaiou medicament. pono e manao oe ia me ka hoʻohana 'ia nā wāhine, ka poe o ka hanau keiki makahiki. I ka pau, ina "Sovaldi" ( "sofosbuvir") ua ia ma ka huipūʻana me "Ribavirin" a me "interferon-Alpha" (maoli genotypes no 3, 4, 5, 6, hepatitis) e e käpae 'ia ma nāʻaoʻao hāpai keiki. He hoi loa kupono e hana i kēia mau konohiki i hāpai keiki, a lactation.

Currently, Ua loaʻa ka aoao o ka "sofosbuvir" reproductive kanaka ike. Aia mea no hoi i 'ike i ka maluhia a me ka hopenaʻoi loa o ka lāʻau i loko o nā mea maʻi ma lalo makahiki 18 o ka makahiki.

Laʻau heluna a me ka lōʻihi like 'ole o ka Inc papa

First mea e stipulate i ka antiviral Inc, ua maikaʻi nō e lawe mai i ka poe 'inikua' Oihana wale nō ka mea i lawa ka hoao ana i loko o ka hana maikaʻi i nā mea maʻi e loaa ana mai ka hepatitis C. A maʻamau regimen - 1 papa (400 mg oʻeleu waiwai) ma ka lā, i loko o kekahi manawa o ka 'ai, inu. E like me ka Akala a (e like me ka lalau ana mai ka lapaʻauʻia hōʻike manaʻo) awaawa "sofosbuvir" E ke ale ole e kamaiʻilio ana a wawahi i ka.

Inā ka papa i ua hookama, a ma ia hope ma ka hope 2 hola Kaleohano ka luaʻi, ka mea, ua? Aeiiaiaoaony e lawe kekahi i kekahi papa. Ma ka hihia o ka luaʻi no ka wā o ka manawa i hala, oi ma mua o 2 hola, lawe i hou mahele lāʻau mea i pono.

Inā ka kekahi mahele lāʻau no kekahi kumu huli mai e e skipped (i ka manawa o ke kali ole e oi aku 18 hola), ka mea, ua waiho, e lawe i ka nalo ana mahele lāʻau, a laila, i ka maʻamau manawa e hoʻomau lapaau. Inā ke kali hou aku i 18 hola - lawe i ka kekahi mahele lāʻau i ka mau manawa.

me ka hui pu therapies

Like eiiiiiaiou prolechivanii adjuvant Inc ma ka hepatitis C, a me ka "sofosbuvir" hana paha "ribavirin", "Alpha interferon", "Daklatasvira", "Ledipasvira", "Asunaprevira".

Nui, i ka tandem "sofosbuvir" + "Daklatasvir" hōʻike manaʻo ola kino mālama poe hana a me nā mea maʻi wehewehe aku i kona mana i ka hepatitis C genotypes 1,2,3.

I ka lā, "Daklatasvir" hiki ke kauoha Pau online WWW.ARV24.COM haawi i kou mau lima - i loko o ka lehulehu me ka lōʻihi-ku kūlana. Eia nae, ua loaʻa nō ka lima a pau o ka mea 'ike e pili ana i ke alo o ka maʻi.

Genotypes 4, 5, 6, ua malamaia lakou nei, medicaments eiiieaena "sofosbuvir", "ribavirin" a me ka "Interferon Alpha". Hae pākōlea manawa mea ma ka liʻiliʻi loa 12 pule. Ma na wahi nā mea maʻi i genotypes 1, 4, 5, 6 i contraindications no ka loaa ana "Interferon, alpha" ua kau paha hypersensitivity i ka waiwai, "sofosbuvir" me "Ribavirin" Ua häʻawi mai ai iä loaa 24 pule.

Tandem "Ribavirin" me "sofosbuvir" lāʻau no ka genotype 2 hōʻike manaʻo hoʻomalu i wehewehe pehea e optimally ka hoʻokō pu ana i ua häʻawi mai ai iä loaa no i ka manawa o ka ole e emi malalo o 12 pule. Kēia mau medicament, akā, ma luna o ke au o ka ma ka liʻiliʻi 24 pule, ka wā e noi 3 genotype o hepatitis C.

Information e pili ana i ka laulā o ka hoʻohui pū Inc me "Ribavirin" a me ka "interferon" no ka iapaau ana o ka genotype 1 mea,ʻaʻole i loaʻa.

Ma ia hihia, ina o ka hoʻomanawanui ua loaa mai ka hepatocarcinoma a / a kaliʻoki kino no ke akepaa transplant, i ka hana o ka i kauoha mai ai "sofosbuvir" ma ka hui pu ana, me ka "Ribavirin" no 48 pule paha a hiki i ka lā o keʻoki kino no ka hui, transplant. He mea nui i mea e pale aku maʻiʻaʻai ana i ke akepaʻa ma hope transplantation.

Lapaʻau haʻawina paipai i ka hui? Eaia "sofosbuvir" me nā ai 'hoʻolako i ka hale hānai maikaʻi virological pane i loko o 92% o ka hihia o ka adjuvant Inc ma ka iapaau ana o ka hepatitis C.

Hikiʻaoʻao waiwai

Ma ka papa o ka lapaʻau e hookolokolo ai i ka lāʻau 'ua loa maikaʻi tolerated e hoʻomanawanui iki mai (e like me ko lakou lākiō i). "Sofosbuvir" ke kumu adverse hanana ma ka hapanui o na hihia wā hoʻohana ma ka hui pu ana, me ka "Ribavirin" a me ka "interferon".

I ka hui "sofosbuvir" me "Ribavirin" pinepine lawa (oi ma mua o 10% o nā hihia) ma ka hemoglobin lehulehu, a ua mahuahua bilirubin e hoike ana o ka luhi emi koko haku mele 'ana, a me ka irritability Kanikani'āʻula, nausea.

Emi mau (emi o 10% o ka hoopii), keia hui malu pu ana o ka ai 'hoʻonāukiukiʻana mai o kaumaha, anaemia, nasopharyngitis, hoʻopōʻino lehulehu, dyspepsia, constipation a me intestinal kāna hana, allergic reactions ma ka ili (ka ohane, wikiwiki). I kekahi manawa, e haʻalele nā mea maʻi, a me kēia mau lākiō i "sofosbuvir" hoʻohana i ia laua me ka "Ribavirin" i ke kumu o ka lauoho poho a me ka hoʻi eha, cramps, myalgia, a me ka asthenia.

Inā 'oe ke hoʻohana i ka luna' o ekolu lapaau (mau luna inoa hou "interferon, alpha"), loa pinepine (oi ma mua o 10% o nā hihia) aia mea he nui lehulehu papa inoa o adverse hanana. Eia mākou e kamaʻilio e pili ana i loli i loko o ke koko: ka mea, ua hoemi i ka helu ana o lymphocytes, neutrophils a me platelets, anaemia, ke kiekie bilirubin pae. Ma ka hapa o ka digestive'āpana e ulu diarrhea, nausea, ka luaʻi. Eia hou kekahi, "sofosbuvir" (Instruction, ahonui e hoike, a ola 'Oihana kākoʻo) hiki i headaches, pōniuniu, cough, maʻi o, maneo a me ka poʻe noʻonoʻoʻole, myalgia a me ka olelo eha. Nā mea maʻi pinepine olelo e pili ana i ka luhi, irritability, ka luaʻi, mahuahua kino mahana.

Emi mau (1 i 10%) e hoomanawanui i olelo e pili ana i na makau, a me ka hooulu ana o ke kaumaha, e ho'ēmi i ke kino ke kaupaonaʻana, no iaiyoe a me ka lehulehu deviations o migraines. Aia ka 'ike e pili ana i ka mea hōʻemi o ka hihio, lauoho lilo, e ulu ai o ka reflux a me ka pokole o ka hanu i ka wa a ka haawe, piʻi pū. I kekahi manawa nā mea maʻi i aku nei au e pili ana i ka eha ma ka hope a me ka pahu, cramps a me ka luhi.

He aha kou pono e ike?

Inā ka hoʻomanawanui i kekahi a oi io aʻe - kiʻekiʻe loiloi mea hoʻomaʻi haawe, fibrosis i loko o ka holomua ke kahua, he pouliʻili - ka iapaau ana o "sofosbuvir" (hōʻike manaʻo o ka poe akamai i, a kuhikuhi pehea e hoʻohana kākoʻo) i ke mahuahua e mai i ka 24 pule. I ka hoʻokō 'o ka hoʻohui pū Inc ka hoʻokō mahele lāʻau "ribavirin" ua koho e like me ke kino ke kaumaha o ka hoomanawanui, oa. E. 75 kg kino kaumaha i kauoha mai 1,2 g. O ka medicament. Ka holoʻokoʻa dala o ka lāʻau ua maheleia i nā māhele, a lawe i ka ai.

Emi i ka laʻau heluna "sofosbuvir" ua i paipai.

Inā he mau palapala noi "Solfosbuvira" a me ka "interferon, alpha" hoʻomōhala hopena maikaʻi 'hoike ana ano o ka hope lāʻau, loaa i kekahi mahele lāʻau o "Interferon" Ua koi' ia e ho'ēmi i 'ole e lawe i kēia ka lapaʻauʻia pau ana (piha rula ma luna o ka ho'ēmiʻana o ka mahele lāʻau a me withdrawal o ka lāʻau, he mea kūikawā ao).

Ma kēia nui ka ua hana ia he mea he hui pu ana, "sofosbuvir" me "Ribavirin", a ua kūkulu i ka hopena maikaʻi ia ma luna o ka? Eaia o ka hope - mahele lāʻau emi iho paha aɃe loa hookipa ana, "Ribavirin". Hope hoʻoikaika i ka hopena o ke koko e ho'āʻo ai, ka mea, ua oluolu ke ho'āʻo i ka hoʻomau 'loaa "ribavirin", e hoʻomaka ana mai 600 mg a me ke kiʻekiʻe o ka lawe ana mai i 800 mg. Ua UaʻAʻole pono ke hoʻonui i ka mahele lāʻau a hiki i ka palapala ana.

Inā e ana i kekahi o ka lapaʻauʻia hui Inc mea pono e lawe i "sofosbuvir" e loa ana - loa mai o ka poe akamai a me ka olelo ao no ka i kuhikuhi i ka ia i loko o keia pili ana.

AaOIeIOUIeXAOAaIN a me nā waiwai

Health poe hana i ole e waiho no nā mea maʻi i loko o laua me ka manaoia lāʻau e hoʻohana antiviral ai '' ē aʻe (koe wale no ka hana maikaʻi kauka) i loko o ke au ka wā iapaau ana ua lawe hepatitis. "Sofosbuvir" hōʻike manaʻo hoʻomalu manaʻo ka mea e hiki ai ke hui pu iho me kekahi mea'ē aʻe wale nō i loko o hihia kahi o ka pomaikai i manaoia, mai ka hui malu pu ana o ka ai 'ma mua o ka Loaʻaʻia kamepiula o adverse loa.

Aia mau no hoi ka pae ana o ai ', ka ami pono me "sofosbuvir" hiki kūpono kou ho'ēmi i kona omo ( "sofosbuvir") i loko o ka naʻau liʻiliʻi. Mau ai '- o anticonvulsants - nā "Phenytoin", "Phenobarbital", "carbamazepine" a me "Oxcarbazepine." Antimycobacterial pūʻulu lapaau i maupaʻa ia mau mea e "Rifabutin", "Rifampicin", "Rifapentine". Mai ka lāʻau lapaʻau kumukanawai a me ka nui loa haʻahaʻa absorbability "sofosbuvir" ke Hypericum. No hoi i paipai i ka hui pu iho la ka lapaʻauʻia me HIV protease nā mea kūpale, "Tipranavir", "Ritonavir".

Special ao

Wale no ke kauka e hoʻokau i ka poʻe uʻi a akau o ka iapaau ana regimen no hepatitis C, a me ka ai 'mea i hoakaka ia no ka "Ledipasvir", "Asunaprevir", "sofosbuvir", "Daklatasvir". Manaʻo Kōkua mai nā mea maʻi a pau generics "Sovaldi" i maikaʻi.

Naʻe, ka mea e e kaʻikaʻiʻia ma ka manao ana, no nā mea maʻi me ka loaʻaʻa puʻuwai e hemahema, e e wae manaʻoi ka mahele lāʻau ka leo. Aia mea i pono, e recalculate i ka laʻau heluna o ka poe i hana eha iaʻi mai mehana i ka lōpū maʻi. Me ka pili ana i ka akepaa nele, aole mea i pono, e hoʻomaʻa i ka mahele lāʻau no nā mea maʻi me kekahi degere o ka oolea o ka maʻi.

Ma ka iapaau ana o ka hepatitis C me ka hoʻohana ma o ka muli o "sofosbuvir" hoʻohui pū Inc uaʻaʻole pono e komo i loko o ia mau hana i kauoha kiʻekiʻe lehulehu a me ka mämä holo o ka psychomotor reactions.

kuai laulā

Ke kāki o kuni lāʻau i loko o Germany mea ma waena o 18 a hiki i 20 tausani Euro. A e kuai ia a hiki i keia kumu kūʻai, e pono i ke kuhikuhi mai i ka hele kauka. Oia ke kiʻekiʻe waiwai o ka huina aie i ka mea i ka poe-nā mea haku polokalamu mea e recoup i kona koina no ka noiʻi, a me ka hoʻomōhala ikea ai o ka lāʻau.

Nui ho'ēmi kāki i ke consumer laau lapaau, nōhie (ho'ēmi analogues momoku ahi me ka loa'ālikeʻeleu waiwai). Ua mea ia ia e hopohopo nei "Daklatasvir", "Asunaprevir", "Ledipasvir" a me ka "sofosbuvir". Consumer hōʻike manaʻo i loko o ka 'ike e pili ana i ke kiʻekiʻe lilo o kēia mau ai', nae, ua mea e kamailio pu ana e pili ana i na umi o na tausani o Euro.

E hoʻomaka ana mai March 2015, e like me ka poe-nā mea haku polokalamu palapalaʻae male, kahe o "sofosbuvir" Natko koa i hoomaka ai i ka Mauna mea lāʻau lapaʻau poʻe (o ka papa, a me ka ae o ke Kuhina o Health o India).

Currently, Rusia mea maoli ma online, hale kūʻai, e kūʻai i ka AEeAaOA (28 papa) lāʻau "sofosbuvir" no ka 39 900 rubles (1 papa e loaʻa i ka consumer i loko o ka nui o ka ma kahi o 1800 rubles). OʻAʻole nike, akā, likeʻo ia'ōpala kuni "Sovaldi" E hoopai waihona kālā i loko o ka nui o 1.5 miliona rubles, i mea aneane 35 mau manawa oi pipiʻi ma mua o ka lilo ana o kekahi nōhie.

Ma hale kūʻai lāʻau lapaʻau, i elua kaula a oe hiki ole kūʻai i kēia k, 'ole. To, ke palapala hoʻomaikaʻi kaʻina hana no ka hou ai' i loko o Rusia Uaʻano lōʻihi.

Ka manao ana o nā mea kūʻai mai a me ka lapaau

Ke medicament i nā mea maʻi me kekahi mau genotypes o ka hepatitis, fibrosis kekahi mau pae me indices o ka transaminase, a me ka nui loa ma luna o ke kūmau, IeAUPIIe, IAa IO he kiʻekiʻe mea hoʻomaʻi haawe ana.

Ke poi pu hapanui o nā mea maʻi i i ka lapaʻauʻia, waiho maikaʻi i kou manaʻo e pili ana i ka "sofosbuvir" 'o ia hoʻi. ʻO wai ka mea, ua malamaia lakou (hōʻike manaʻo pinepine apo ia 'ano' ike) mua hepatitis C interferons paipai ia ai 'ke hiki ole hoohalike. Interferons i kekahi wahi lihi iki o kaʻaoʻao waiwai, a me ka ole a pau nā mea maʻi i ka ikaika, e hali ia lakou. Like no ka hui malu pu ana o "sofosbuvir" a me ka "Daklatasvir" (loa pinepine nā mea maʻi e olelo aku no ia i ka tandem), wale heʻuʻuku pakeneka o ia i mau Luna i olelo mai ai e pili ana i ka hooulu ana o ka liʻiliʻi hopena maikaʻi 'ole like pōniuniu, headaches,ʻaʻole ikaika a me ka pōkole-makahiki poho o ka ōhumu. Eia naʻe, i kēia mau symptoms mai e hele i kekahi e like me kaʻaoʻao 'ole o ka "interferon" a me ka hopena o ka hepatitis. I ka pau ana o 2-3 pule o ka Inc i loko o na mea he nui nā mea maʻi, noho hoʻi i ka maʻamau ka maʻiʻo ma ke akepaʻa transaminases. E hoʻomaka ana mai o ka hebedoma kolu o ka lapaʻau luna 'antivirals "sofosbuvir" a me ka "Daklatasvir" ma na mea he nui nā mea maʻi no ke alo i loko o ke kino o ka hepatitis C mea hoʻomaʻi io.

No hoi, he nui loa nā mea maʻi e hōʻike i he nui ka ho'ēmiʻana o ka fibrosis i loko o kekahi mau mahina, ka hoʻohana 'ana o ka pu Inc.

O na nā mea kūʻai mai ka poe i lawe i ka luna 'o ekolu lapaau - "sofosbuvir", "Daklatasvir", "Ribaverin" - no hoi he nui oluolu i ka hopena o ka lapaau.

Aneane pau nā mea kūʻai mai "sofosbuvir" walaʻau e pili ana i kekahi maoli Hopu i loko o ka iapaau ana o ka hepatitis C ma e like me ka interferonotherapy. Ālai 'hoʻoikaika' ana i ke ola kino a me ka pono o ke ola - i ka pololei maopopo.