"Moxifloxacin": aʻo no ka hoʻohana 'ana, hōʻikeʻano, haku mele' ana

Ka medicament "Moxifloxacin" pharmacological hopena o ka i ana au i ke hoakaka ia mahope, pili ia i ka pae ana o quinolones. Ke hoʻopololei i ka bactericidal, antibacterial hopena. Next, i kūpono ai ka lapaau "Moxifloxacin" mākou hewa o ka lawehala. Na Ke Kumu no ka hoʻohana 'ana, analogues e kekahi e hōʻike i ka pauku.

kanawai

Pehea kaʻeleu Agena "Moxifloxacin"? Description o ka lāʻau e hoʻomaka me ka hōʻike o keʻano papa hana o kona kanawai ma ka koʻohune. me ka inhibition (suppression) o ka mea koʻohune topoisomerase IV a me II Bactericidal hopena hana pili. Kēia, ma ka huli, hiki aku ai i ka haunaele ma ka replication keʻano o ka hanaʻana o ka EKOLU, DNA? Aiiio biosynthesis microbial keena. E like me ka hopena, ma laila e hele mai lākou e make ai. Medicament "Moxifloxacin" manual wehewehe like me ka palahalaha pae antibiotic.

e kū'ē'ē mai

Ma ka antibacterial hana o ka ai ' "Moxifloxacin" mai i pili i nā maomeka e hoonaukiuki i ka ia'ku i tetracyclines, macrolides, aminoglycosides, cephalosporins a me penicillins. Ua i ia pono, a me ka hope o ke kea-e kū'ē'ē mai. Hiki i keia manawa, na hihia o ka wai koko kumupaʻa i ole hōʻike '. Uluwehi O ia'ku "Moxifloxacin" ulu muli o kona kulana lohi e mau mutations.

huahelu o ka ha awina

O ia hoʻi, "Moxifloxacin (manual - kona hoaoia'na,) e loli ai na mea he nui ke kanana nei o Gram-maikaʻi a me Gram-io koʻohune,ʻakika-hookeai koʻohune, anaerobes, atypical microorganisms (mycoplasma, chlamydia, a pela aku), a me ka hoi koʻohune mea e hoʻopale ai i macrolide a me ka Hoʻokolohua-lactam antibiotic ai ' .

omo

I ka loaa ana i ka moʻolelo omo o ka lāʻau "Moxifloxacin" kokololio, a aneane piha. Loa bioavailability ka wā lawelawe intravenously a ana naau - no ka mea o ka 91%. Wā lawelawe hōʻike waha '(50-1200 mg mahele lāʻau, 600 mg / lā no 10 lā) laina pharmacokinetics o ka lāʻau. ʻO kā mākou lehulehu me 400 mg malama ma hope o 0.5-4 hola. I ka pili ka poʻe me ka ai loaʻa ka hua i loko o ka lōʻihi like au Cmax (, elua no hora) a me kona ka ho'ēmiʻana ma kahi o 16%. Duration omo penei koe ua hoʻololiʻia. Aka hoi, i kēia mau 'ike e ole i ka lapaʻau cia e leie aku ka hoʻohana' ana i ka lāʻau "Moxifloxacin", nānā 'ole i ka ai. Ma hope o ka hookahi intravenous infusion o 400 mg no ka hora i kā mākou lehulehu ia lŘlŘ ma ka hope o ka infusion.

hoi o ka makana

I loko o nā lāʻekolu o ka palapala noi ua hiki equilibrium. Paa i ka wai koko nā polokina - ma kahi o 45%. Ua memo 'ano kokololio hoi o ka makana o ka lāʻau "Moxifloxacin" nā loko a me nā'aʻaʻa. Highest nā hoʻohui like i loko o ka akemāmā'aʻaʻa a me ka bronchi mucous,ʻili a me ka subcutaneous hale, sinuses, hoʻoʻino foci. Ke tuha a interstitial loli medicament ua loaʻa i loko o MAKAHIKI MDCCCXVI NU nā polokina, noa palapala. Kona lehulehu, uaʻoi kona kiʻekiʻe ma mua o ka wai koko. Together me keia k ua loaʻa i loko o nui dala i loko o nā loko peritoneum nā'aʻaʻa wahine wahine nā loko, a ma ka peritoneal loli.

pūnao

Medicine "Moxifloxacin" (hōʻike o ka lāʻau i loko o ka annotationʻikepili maupaʻa 'ike) hele i ka lua o ka biotransformation pae. ʻaʻa puʻuwai excretion hoʻokō'ōnaehana a me ka naʻau liʻiliʻi unaltered i loko o ka palapala o ka sulpho i huiʻia me ka AEeOEXAaI glucuronide. Ua loaʻa nā metabolites i loko wai koko. Lākou lehulehu haʻahaʻa ma mua ia o ka palapala i huiʻia. Haʻawina i hōʻike, i kēia mau hoʻololi iho huahana mai ole i ka io ole ma ke kino

O ia hoʻi, "Moxifloxacin", mai i ka mea, ua kuhikuhi?

Ka lāʻau 'Ua pono no infectious hoʻoʻino pathologies i loko o nā mākua i hoʻonāukiuki aku ma microorganisms ka pā lonoaʻili ana. Ma 'ana, nāʻikepili hai aku i ka exacerbation o ka maʻi bronchitis pele, huʻi sinusitis, pneumonia (kena ae la ma ke kanana nei o koʻohune hoike mau ia'ku i na. H. Ka antibiotic) kaiāulu-lilo. O ia hoʻi, "Moxifloxacin" kauoha no ka hoʻohana paipai no nā mea palahēhē oʻaeʻae'aʻaʻa a me ka ili, subcutaneous hale huikau lesions (iho mailoko o diabetic wawae like hoʻi), a me ke kūʻai '-abdominal nā mea palahēhē (polymorphic keʻano o ka hanaʻana, intraperitoneal abscesses, a pela aku). Ua ia ka wā o ka medicament mai Streptococcus pneumoniae hoʻopale i mau antibacterials, a me ke alo o ka hoʻopale ke kanana nei i ka penicillin, elua a oi pūʻulu o ai 'o ka lua o ka hanauna cephalosporins, macrolides, tetracyclines. Ma nāʻikepili pū nā hoʻoʻino lesions ma ka pelvic nā loko uncomplicated ano. I ka endometritis a me ka salpingitis e hoi hoʻoikaika e noonoo i na mea (e like me ka hoike ana o ka pili a hiki i ka lāʻau "Moxifloxacin" kauoha no ka hoʻohana). Eye kulu i hoakaka ia no ka mea koʻohune conjunctivitis, hoonaukiuki ma microorganisms ikepili koʻikoʻi i ka medicament. Ua mea no hoi e pono ke lawe i ka mooolelo o ka na iapaau ana o infectious pathologies alakaʻi.

Medicament "Moxifloxacin": ka laʻau heluna a me ke ala o ka hooponopono

Haawina i koho naau (hōʻike waha ') a intravenously. . Duration o ke lapaau i ka medicament "Moxifloxacin", ka laʻau heluna o ka a - 400 mg / lā, ke kaumaha ma muli o ka 'ano o ka maʻi a me kona oolea, e like me ka malama pākōlea hopena:

• Exacerbation o ka maʻi bronchitis papa - 5-10 lā.
• Community-lilo pneumonia - 7-14 lā sequential Inc (intravenous ukali e ku unaʻai ana).
• Kahi I'aʻaʻa, ili (uncomplicated), a me ka huʻi sinusitis - 7 lā.
• A hiki ke kūʻai '-abdominal nā mea palahēhē (huikau) - 5-14 lā sequential Inc.
• I ka huikau lesions a me subcutaneous nā hale o kaʻili - 7-21 lā.
• Ma hoʻoʻino pathologies o ka pelvic nā loko - 14 lā.

No ka 'ike hou aku, he pili ia i ka lāʻau "Moxifloxacin" manual. Papa e ole e ae, e mama. Holoi ia me ka wai ka pono i loko o ka uuku buke.

hualoaʻa hoʻohana

Medicine "Moxifloxacin" (kulu) i e lawelawe i nā mea maʻi ma ka makahiki. Mea hōʻike i ka hana hou mai ma ka lima o ka lā. Ma hope o ia 'oe e hoomau oe iapaau ana no kekahi 2-3 lā. Nā mea maʻi i loko o ka hoʻohuli ai i nā maka haʻaheo lāhui i ke kulu ekolu mau manawa o ka lā. Inā he mea i kanawai no elima mau lā ke hoala mai i ka ninau o ka pono o ka Inc aʻike. Ka lōʻihi like 'ole o ka lapaau hilinaʻi nui ma luna o ka papa bacteriological a me ka lapaʻau a me ka oolea o ke pathology.

Hou ma no ka infusion pāʻoihana

Medicament "Moxifloxacin" manual ia kekahi e komo i ka hora. Ka lāʻau 'pela ke e ma undiluted paha ma nāu kekahi palapala. Ke kākoʻo pāʻoihana He hana maʻalahi me ka paʻakai koloriside 0,9%, ka wai no ka pahu kui, dextrose pāʻoihana ma ka lehulehu o ka 10% a me ka 40%, 20% xylitol, "Ringer". E hoʻohana i akaka wale nō ke kinowai. Ma hope o dilution o ka medicament koe hale hānai no ka lā i mehana ea. E ole e mālama i loko o ka Pahu Hau mea. Inā e ka lawelawe i ka infusion me nā konohiki, kela mea keia mea o ka i lawelawe kaawale.

ʻaoʻao waiwai

Aie i ka iapaau ana ka lapaʻauʻia "Moxifloxacin" paha, e hoʻoikaika i nā mea palahēhē fungal, leukopenia, anaemia, thrombocytopenia. Ma kekahi mau hihia, o ka Inc he mea he mahuahua i ka prothrombin manawa, thromboplastin nā hoʻohui like ka loli. Ma kekahi hoʻomanawanui iki mai i ka lāʻau hiki i allergic reactions, laryngeal edema, urticaria, anaphylactic kŰia, pruritus, eosinophilia, wikiwiki. Ma pohihihi keia hihia, he mea hyperglycemia, hyperlipidemia, hyperuricemia. Ma ka iapaau ana o paha ka noʻonoʻo 'kāna hana. I ka pau, nā mea maʻi i ka mahina hyperactivity, uunu nui, kaumaha, depersonalization, hallucinations, psychotic reactions, pu ma suicidal manaʻo. Commonʻaoʻao waiwai nā headaches, pōniuniu, tremors, drowsiness, ka hilahila, ono pā lonoaʻili kāna hana, hiamoe haunaele, disorientation. Ma kekahi mau hihia, i lapaʻau me ka lapaʻauʻia e ke hihia hoʻi ōhumu, ke kāʻili 'ana, pu ma na lapaʻau hoikeana, hypoesthesia, kāna hana o ke ano o ka hohono. A helu o nā mea maʻi i worsening o ka olelo, noonoo,ʻike ākea neuropathy, amnesia, polyneuropathy. I ka pili topically, hihio e deteriorate a kona make. Naʻe, i ka hope o ua manaoia e e he transient kulana.

Ole ma ka mea'ōnaehana mānowai koko'ōnaehana

Part o ka hopena o ka noi o ka lāʻau "Moxifloxacin" i ka QT-wā mawaena prolongation i loko o nā mea maʻi me ka hypokalemia, palpitations, vasodilation, tachycardia. Pohihihiʻaoʻao waiwai nā hypertension a me ka hypotension, ventricular tachyarrhythmias, syncope. Loa kākaʻikahi mālama cardiac hopu. Mau ka hapanui typical no kanaka predisposed i ka huʻi ischemia, bradycardia (clinically nui).

Hopena ma luna o nā nenoai a me nā loko

Ma kekahi mau hihia, i ka lāʻau hiki i pokole o ka hanu, a me asthmatic kulana. Ua malama A helu o nā mea maʻi kāna hana i loko o ka digestive'āpana. Ma kekahi, e kū'ē i ke kāʻei kua o ka iapaau ana-emergent nausea, ka luaʻi, diarrhea,'ōpū eha. KŘpa a ua manaoia mauʻaoʻao waiwai ilihune ikaika loa ka makemake, dyspepsia, flatulence, gastroenteritis (koe wale no ka erosive), constipation. Kekahi hoʻomanawanui iki mai i ua hōʻike 'stomatitis, dysphagia, pseudomembranous colitis. Ke Inc e paha mahuahua ma transaminases, hepatic dysfunction, i ka ulu ana o ka fulminant hepatitis, hepatic hoʻokō 'ole' ana i ke ola-na olelo hooweliweli au. Loa kākaʻikahi malama bullous cutaneous reactions (ʻawahia epidermal necrolysis, Stevens-Johnson maʻi pale). Kekahi nā mea maʻi ua hoano e myalgia, arthralgia, convulsions, mahuahua Muscle leo, tendonitis, Muscle nawaliwali. tendon ruptures ke hana i loko o pohihihi keia hihia, arthritis, gait haunaele like me ka hopena o ke poho a hiki i ka musculoskeletal nenoaiu. hiki i nā mea maʻi ma ka iapaau ana me ka lapaʻauʻia e ae nānā mau kāna hana o ka urinary nenoaiu. Ma kekahi, ia dehydration (hoonaukiuki diarrhea a emi ma ka kinowai buke hoopauia),ʻaʻa puʻuwai dysfunction, insufficiency. Commonʻaoʻao waiwai nā sweating, nonspecificʻeha, malaise. Ma ka intravenous paha thrombophlebitis paha phlebitis.

ʻO wai ka mea i häʻawi mai ai iä na mea?

I ka lapaau "Moxifloxacin" contraindications e like penei:

• Tendon pathology ma ka moolelo e hoʻomohala i ka hopena o ka Inc quinolone antibiotics pae.
• Loaʻa nui elongate QT-wā mawaena (congenital a lilo).
• Electrolyte haunaele (pakahi aku la ia hypokalemia uncorrected).
• Bradycardia (clinically nui).
• Heart ole me ka ho'ēmi i kā ejection hana i loko o ka ventricle hema.
• Aʻe ' naau pāpana (ma ka mōʻaukala).

I ka lactose intolerance, monakō koko-galactose malabsorption, lactase deficiency ua hoi i paipai medicament "Moxifloxacin" (lāʻau haku mele 'ana maupaʻa lactose, nolaila, na pathologies i oleloia e komo i loko o ka papa inoa). 'Aʻole i hāʻawi ia hoʻi, hapai ole lactating. Papa a me ka pāʻoihana i aeia e mākaʻikaʻi nā mea maʻi makahiki 18 makahiki. Paipai lāʻau ma ka hihia o ka hypersensitivity i na eiiiiiaiou.

kūikawā hihia

Mālama nui ua pono i ka hookohu o ka lāʻau a hiki i nā mea maʻi me ka Central ko mākou hopohopo'ōnaehana abnormalities e predispose i ke kūpono 'ana o ke kāʻili' ana. Ke kamepiula pūʻulu nā nā mea maʻi me ka proarrhythmic Hawaii. Mau nā, ma ka nui, nā huʻi ischemia, o ka oi aku i loko o ka kūpuna a me nā wāhine. I malama mālama nui i loko o nā mea maʻi i ake cirrhosis. laʻau heluna hoʻoponopono i ke koi 'ia ma concurrent Inc hoʻi ua hakumakuma i ka lehulehu o ka potasiuma.

No ka 'ike hou aku,

Mea hōʻike i ka lāʻau ua pono tolerated ma na mea he nui nā mea maʻi. Hoʻomalu pinepine i koi 'ia ke koʻi no infectious lesions. O ke kumu ho i ka mea i ka lāʻau i ka kŘpa a kiʻekiʻe ka hoʻokōʻana o ka nui koʻohune. Eia naʻe, he mea mau i ka pilikia o kaʻaoʻao waiwai, a i komo i ka huina hoonui ao "Moxifloxacin" manual. Analogs o ka lāʻau ma ka hihia o ka pono e koho i ke kauka pākahi. E puku i mea paahana e hiki mau ai 'like: "Avelox", "Vigamoks", "Rotomoks", "Moksifur", "Moksin" a me na mea e ae. A hiki aku i ka hopena maikaʻi 'ole, i ka pahi mea hōʻemi, a hanana o symptoms i mea ole hōʻike i loko o ka hōʻuluʻulu manaʻo, e pono e imi koke' inikua noonoo. I ka hoʻohana 'ana i nā paka ua e pale aku hui' ana me excessive dala o ka lāʻau i ka maka. Inā keia hana, e pono like 'āwīwī i hiki me ka nui o ka wai. I Ina o ka overdose holomua o kaʻaoʻao loa.

ma ka hopena

Ka lāʻau "Moxifloxacin" noʻonoʻo pono potent antibacterial. Ma pili ana me keia loa ia ua e waiho i ka uhai i ke kauka o ka kuhikuhi. Ma kekahi, e pili ana i ka helu a me ka alapine (frequency) o ka palapala noiʻano. Mai oi i ka laʻau heluna. Intravenous ka pahu kui e halihaliia oia iwaho o ka kūikawā study ma ka palapala hōʻoia no limahana nana e e hiki ke kokua ina e pono ai. Oe e ole ka hoʻoponopono-lapaʻau. I ka wa e kaawale aku o ka hopena o ka Inc mea e pono ke ike i ke kauka. Pono mamua, e hoʻohana i ka lāʻau "Moxifloxacin" E akahele heluhelu i ka olelo.