"Nimesulide": hōʻike manaʻo, hoʻohana a analogues

Nonsteroidal antiinflammatory konohiki mea he kūikawā papa o ka ai 'ka nui ekolu ole: antiinflammatory, antipyretic a me ka analgesic. Ma muli o ia mau pharmacodynamic ano o keia pae o ka ai 'ua hoʻomano hoʻohana' ia i loko o 'inikua hana. E ka nānā aku i nā hiʻona o ka palapala noi "Nimesulide" lāʻau, ahonui e hoike e pili ana i kēia lāʻau lapaʻau huahana, e like me ka hiki adverse ole a me nā hiʻona o ka dosing.

pharmacodynamic ano

"Nimesulide" ka 'elele o ka pae o ka' ole-steroidal Anati-hoʻoʻino ai '. Ma kona lāʻau pae pili ia e wae nā mea kūpale o ka'ūhū cyclooxygenase-2, i ka mea pono, e loaʻa ai inhibition o? Iecaianoaaiiuo o prostaglandins ma ka li nui.

Kekahi kiʻiona hiʻona o keʻano papa hana o ka hoʻokō ' "nimesulide" hoʻomanaʻo o kona hiki e inhibit wehe i ka'ūhū kapaia myeloperoxidase, a me ka nui loa inhibits ka? Iecaianoaaiiie o noa radicals ole ka heluna o keʻano o ka hanaʻana a me ka chemo- tigmotaksisa a me ka phagocytosis. Eia hou kekahi, "nimesulide" ka poʻea pau e suppression o ke kahua o ka ʻeho necrosis ololi a me nā 'uao i komo i loko o hoʻoʻino reactions o ka meaola.

Ke pharmacokinetic ano o

I ka papa kuhikuhiE ala hele o ka hooponopono ana o ka medicament mea ku una, ku pono i ka bioavailability kiʻekiʻe o ka lāʻau, uku o kā mākou lehulehu ma ka wai koko o nā mea maʻi. Pela, ua loaʻa i ka i kā mākou lehulehu ma hope 120-180 minuke ma hope o ka hoʻoponopono, a me ka degere o ka paa o ka lāʻau me ka wai koko nā polokina mea kokoke i ka 98% o ka kope hoʻolauna dala "nimesulide" ko lakou hoomakaukau ana (lākiō i nā mea maʻi, a kauka e hooiaio ia).

I ka papa kuhikuhiE kino i loko i ka lāʻau pūnao o ke akepaʻa. Ma ke kaʻina hana o ka biotransformation i loko oʻeleu metabolite kapaia hydroxynimesulide. I ka papa kuhikuhiE ala hele o ka excretion o ka lāʻau o kona excretion i loko o ka mimi (no laila, IeEeAUUXAAaO ma kahi o 65% lāʻau), ua excreted ma kahi o 35% o ka lāʻau i loko o ka faeces.

ʻaneʻane a pau nā mea maʻi ma mua lawe ana ka lanakila o kekahi hou 'ike e pili ana i ka lāʻau "Nimesulide". Na Ke Kumu no ka hoʻohana 'ana, analogs, nāʻikepili a me contraindications,ʻaoʻao' ole - o ka loa pinepine ia noi ninau.

nāʻikepili

Nāʻikepili no ka lāʻau "Nimesulide",ʻaʻole no ka nui loa. I waena o lākou e pono ke kūʻai 'ana i kumumanaʻo huʻi eha i kupu mai, me ka iniiaiie osteoarthritisʻeha, a iniiaiie dysmenorrhea ia lŘlŘ. Ma pediatric me ka hana pono e like me ka hoʻokō 'ana o ka lāʻau. Keia ua mea e hoikeike ma ke komo haʻalele "Nimesulide" 'o ia hoʻi hōʻike manaʻo. ka mea, ua i? aeiiaiaoaony e kuai i na keiki ma lalo o 12 makahiki o ka makahiki - ë he mähele wale no keia.

Contraindications i ka lāʻau

Like a pau nonsteroidal Anati-hoʻoʻino ai ' "nimesulide" ua contraindicated ma ke alo o gastric ulcer ole duodenum kina (12 duodenal ulcer) i loko o ka huʻi ke kahua, ua hakumakuma ka detoxifying ake hana, oiai i kauoha mai ai i ka lāʻau a me hepatotoxic ai'. Ka lāʻau 'Ua contraindicated i loko o nā mea maʻi me ka nui emi i loko o kaʻaʻa puʻuwai excretory hana (creatinineʻae emi o 30 ML / min), hematological kāna hana a me clotting pilikia, nā mea maʻi me ka hoʻopōʻino mea'ōnaehana mānowai koko kuleana pili i.

"Nimesulide" ua contraindicated ma ke alo o nā mea maʻiʻoki lāʻau lapaʻau pathology, hapai a me ka poe makuwahine, a me na keiki ma lalo o 12 makahiki o ka makahiki no ka mea, o ka pahiki kiʻekiʻe o adverse reactions. Ia mea,ʻaʻole e pono ke hāʻawi aku "Nimesulide" no ka lapaau o ka maʻi palū a me ka maʻi palū-e like ana o ka hyperthermia.

ʻaoʻao waiwai

Kēia hana,ʻaʻole wale wehewehe aku ma ka kiʻekiʻe Anati-hoʻoʻino haʻawina akā, i ka mea hiki wale mai kiʻekiʻe o adverse reactions. Ka mea ana i hookuu loko o ka hebedoma mua o ka Inc me "Nimesulide". Reviews o ka hanana o kaʻaoʻao 'ole haʻalele nui ia e makemake.

Skin a me ka iliʻaoʻao 'ole e pili ana me na hoikeana o allergic reactions i ka lāʻau a me ka a e hōʻike i ka hanana o ka ili maneo a me rashes, dermatitis, redness, urticaria. Loa emiʻaoʻao 'ole ana e like me ʻawahia epidermal necrolysis, Stevens-Johnson maʻi pale.

Ma ka hapa o ka gastrointestinal'āpana kākaʻikahi hiki i kahe ana ke koko, perforation o ulcers. More pinepine e ala aʻeʻoe i loko o ka eha o ka epigastric aina, nausea, ka luaʻi, diarrhea paha constipation.

Ma ka hapa o ka Central ko mākou hopohopo'ōnaehana hiki i lethargy, excessive sleepiness, ka pinepine headaches a me kāna hana pōniuniu, vestibular kāna hana.

Mai kaʻaoʻao o ka hematopoiesis'ōnaehana a me ka mea'ōnaehana mānowai koko'ōnaehana i hoʻoikaika i eosinophilia, thrombocytopenia, a me ka pancytopenia, anaemia maʻi pale, tachycardia, ua hoʻokiʻekiʻeʻia ke koko, no ka hooulu ana o ka hyperkalemia.

Ka hoʻohana o "Nimesulide" a me ka hōʻike manaʻo

E ho ohana i ka "Nimesulide" paa ia kona wahi i loko o lapaʻau rheumatologic maʻi o ka musculoskeletal nenoaiu. I loko nō o ka nui hoʻokau 'ma ka hoike ana i ka lāʻau "nimesulide" maikaʻi i kou manaʻo e pili ana ia ma muli o ia kona kiʻekiʻe ka hoʻokōʻana i loko o ka iapaau ana o rheumatic ka maʻi. Keia mea aie a hiki i ka specificity o ka waiwai ma cyclooxygenase-2 a me keʻano kiʻekiʻe o ka selectivity no keia'ūhū.

Cautions

He aha pono e akahele ka wā e lawe i kēia lāʻau 'like "Nimesulide"? Na Ke Kumu no ka hoʻohana 'ana, ahonui hōʻike manaʻo hōʻike aku e pili ana i kekahi mau olelo ao. An nui wahi i loko o ka mākaʻikaʻi "nimesulide" hoomalolo o ka hoʻohana 'ana o ka palena iki pākōlea mahele lāʻau o ka lāʻau. I ka wa e kaawale aku o ka hopenaʻoi loa me ka palena haʻahaʻa dosing e loaa ana i ka lāʻau e ke hele.

Ma ka hihia o hepatotoxicity o ka lāʻau (i ua ua hoʻonānā ma ke koko biochemistry) e loaa ana i ka lāʻau 'i pono e pani koke. Kēia pūʻulu o ka hoʻomanawanui iki mai (e hoʻomōhala aeea ake eha) hou paha hiki ole "Nimesulide." It E e kaulana ia a hiki i ka wa e kaawale aku o kaʻaoʻao waiwai akepaʻa lāʻau e ole e hui me ka hepatotoxic ai ', nā NSAIDs, analgesics. No hoi, e hooki ma ke inu waiʻona.

"Nimesulide" E e ke kiʻekiʻeʻano o ka mālama nui i haawiia mai ai i nā mea maʻi me hepatic aʻaʻa puʻuwai insufficiency, e pale i ka pilikia o ka Holomua o ka hope.

E e uku ai i ke koho ana i ka lāʻau, e hoʻomanawanui iki mai me ka maʻi palū-e like symptoms pakahi noonoo. O ke kumu ho i ka mea i "nimesulide" inā paʻa antipyretic ai a me ka mea hiki ke makakiʻi na symptoms o ka mea koʻohune maʻiʻaʻai.

Uluwehi O hana kūleʻa

Aie i ka hiki kiʻekiʻe o ka lāʻau i ka i intestinal kahe ana ke koko "Nimesulide" E ole e hui me anticoagulants e like me "Warfarin" me he mea he pilikia kiʻekiʻe o kaʻaoʻao loa.

Ka hiki o ka lāʻau ma loko i ka hana o ka cytochrome P450. Ma nānaina o ka ooieoeiiaeuiiai ha awina o inhibition o ka'ūhū laʻau heluna o ka ai 'metabolized ma ka mea o ka cytochrome pono e hooponopono hou i lalo.

"Nimesulide": analogues, hōʻike manaʻo

O ka papa kuhikuhiE analogs (e like me kaʻeleu Agena) e "Nimid", "Nimesil", "Remesulid", "bipi-sanovel". Ka lāʻau 'Ua loaʻa ma ka papa palapala 100 mg sachets paha i loko o ka palapala o ka tuko pīlali i 10 mg (no 1 g. O ka tuko pīlali). Pākōlea ha awina o analogues o ka lāʻau mea maikai, pela no nā mea maʻi e pili ana i kā lākou mau hōʻike manaʻo haʻalele like maikaʻi. Nā mea maʻi e waiho ana i ka "Nimesulide" 'o ia hoʻi nāʻana, papa e uuku ma mua o ka lāʻau i loko o ka palapala o ka sachet.

ka hopena

"Nimesulide" mea he potent Anati-hoʻoʻino Agena e hana hoʻoʻino maʻi, o ka oi aku musculoskeletal nenoaiu. eʻoiaʻiʻo e kukakuka me kou kauka e pili ana i ka lawe "Nimesulide" lāʻau no ka mea, o ka mea kamepiula kiʻekiʻe o kaʻaoʻao 'ole ka pono. Waikiki kauka kuhikuhi i ka lāʻau, a me nā mea maʻi lawe kona 'oluʻolu, no ka mea, ka paipai' ana kokololio ka ho'ēmiʻana o ka maʻi symptoms.