Recombinant erythropoietin. Recombinant kanaka erythropoietin

Erythropoietin (EPO) - glycoprotein hōmona e hoʻi i ka uku o ka erythropoiesis i loko o kānaka. Na keia hui ua synthesized kuhikuhi i loko o nā puʻupaʻa, he uuku dala (ma kahi o 10 pakeneka) ua hua mai i loko o ke akepaʻa. Ka hōmona erythropoietin haʻalele no ka mahele a me ka differentiation o erythroid a hiki. Pae o endogenous hōmona i loko o ke koko wai koko o ola kanaka loli aʻe i loko o ke akea huahelu a me ka mea inversely hapaʻauhau i ka hemoglobin lehulehu, a me ka degere o ka oxygenation o nā'aʻaʻa. E hana ma ka hoʻokaʻawale a? Iecaianoaaiiie o keia hōmona i mea e lapaau ka loa maikaʻi kēia.

'Ole a me ka waiwai hōmona

Ke lātoma ninoieo o ka'amino nāʻakika hōmona. At deficiency o endogenous erythropoietin i Ua heʻoi emi i loko o ka nui o ka hemoglobin a me kaʻulaʻula koko keena, ka mea, ua ulu ka ai-kapaia eritropoetindefitsitnaya anaemia. koe hiki ole no ka nele o kūpono mea lāʻau lapaʻau hiki i nei, e like me ka lāʻau? iaea o ka anemia. I kēia lā, me ka nele ma luna o ka hōmona i loko o ke kino o ke kanaka, kauka i hoakaka ia recombinant erythropoietin. Ka makaukau i loaa mai ka holoholona keena ma a ka hoʻolauna'ōewe code for Na kanaka EPO. Recombinant kanaka erythropoietin ma ka'aminoʻakika a me ka haku mele 'ana carbohydrate mea'ālike i ka hōmona maoli, maoli i ka helu o kaʻulaʻula koko keena, reticulocytes, haʻalele no ka biosynthesis o hemoglobin i loko o na keena. Ke liluwelo ha awina o ka kūpono nā mea i okoa mai ka endogenous hōmona. Recombinant erythropoietin Aʻole e ho'āʻo cytotoxic 'ole, a' aʻole i pili i ka leucopoiesis. ʻepekema paipai i EPO pāʻani aku me kekahi eritropoetinchuvstvitelnymi receptors, a i aia ma luna o ka halepaahao ili honua.

A kaʻina hana no ka hoomaemae recombinant kanaka erythropoietin

Recombinant kanaka EPO - o kekahi o ka loa nui nā polokina hua mai ma na mea he nui liluwelo a me ka mea lāʻau lapaʻau poʻe a puni ka honua no ka lāʻau Inc. Na keia hui ua synthesized ovary keena Chinese hamster (ma) ma recombinant DNA 'ana i kūpono. Kekahi polypeptide kaula recombinant EPO be 165'amino nāʻakika, ka pōpilikia hakakino kaumaha o 24.000 Yeah, a me ka malama hakakino kaumaha o ka glycosylated kumuʻiʻo - 30 400 Da. Branch erythropoietin mai impurities ua lawe mai ma ka ion-mail, aʻo Solomona chromatography. Kanaka recombinant EPO i ka maemae o 98%.

Recombinant erythropoietin a me analogs kona mau

E hoʻoulu erythropoiesis kaʻina kauka hoʻohanaʻokoʻa ai ':

• "Aranesp";
• "Aeprin";
• "Epobiokrin";
• "Bioein";
• "Vepoks";
• "Binokrit";
• "Epokrin";
• "Gemax";
• "Epogen";
• "Eprex";
• "Epovitan";
• "Epomaks";
• "Giperkrit";
• "Eralfon";
• "Eritrea";
• "Recormon";
• "Epostim";
• "Epozino";
• "Epoetin Hoʻokolohua".

Mua oe e puku i ka recombinant erythropoietin analogues, e nīnau aku i ke kauka.

nāʻikepili

Lapaʻau o nā loea pinepine i ka hana me ka eritropoetindefitsitnymi anaemia (EDA). Kēia pūʻulu nā ke kēia pathologies:

• anaemia o malignant neoplasms;
• kakahiaka anaemia o prematurity i hāʻawe (mua 34 pule gestation) me ke kino kaumaha o 750 a hiki i 1500 g.;
• nephrogenic anemia;
• Anemia i ka maʻi maʻi (hepatitis C, rheumatoid arthritis, HIV maʻiʻaʻai, alimentary Canal maʻi).

A kiʻiona hiʻona o ka luna-deficiency anaemia o ka mea i ka mea, i ole ia hao hoomakaukau. A nei, ka mea wale nō ka hoʻokō Inc o ka transfusion. Aie i ka mea i kēiaʻano o ka Inc mai he nui helu o kaʻaoʻao mau waiwai, a me ka pilikia kiʻekiʻe o ke EYI o ke koko-hanau pathogens o ka pilikia infectious maʻi (HIV, hepatitis nā mea hoʻomaʻi, etc.), keia hana i ke kālā no lapaau ua aneane loa i hoʻohana. Recombinant kanaka erythropoietin kōkua, e hoʻoikaika i ka pono o ke ola no nā mea maʻi me kaʻike, o "eritropoetindefitsitnaya anaemia." Biosynthesis a me ka hoike ana o recombinant kanaka EPO wehe i ka hou au i loko o ka iapaau ana o ka anemia eritropoetinzavisimyh.

Contraindications

Kauka mai e waiho aku i ka lawe ana o recombinant erythropoietin (e manual ao mai e pili ana ia) i loko o ke alo o ke kēia mau pathologies:

• thromboembolism;
• hypersensitivity i ka lāʻau;
• impossibility o ka hoʻokō anticoagulant Inc;
• hoolilo cerebral mapuna hoe a myocardial infarction;
• lolelua ka angina;
• kipi hypertension;
• manawa o ka hanau keiki ana a me ka breastfeeding;
• refractory hypertension.

dosing regimen

Ka laʻau heluna a me ka lōʻihi like 'ole o ka hana noaia i kukulu ai ma ka pololei kanaka kumu, ke kaumaha ma muli o ka oolea o anaemia, me ka nui ana o ka hoʻomanawanui a me ke ano o ka pathology. Ka lāʻau 'Ua manao ia no ka parenteral ana. Ka loiloi mua nā māhele ke oko a ma ka laulā mai ka 50 a hiki i 150 Iu / kg. Ka mahele lāʻau E e like ke kaumaha ma muli o ka hoʻomanawanui i ka makahiki. Recombinant erythropoietin ua ana lawelawe iho la no 3 manawa i ka pule. Inā overdose ua ua māhuahuaʻaoʻao ole. Ka hopena i oi a emi hiki ma hope 2-3 pule o ka palapala noi.

ʻaoʻao kanawai

Oe i kauoha mai ai recombinant kanaka erythropoietin? Na Ke Kumu no ka hoʻohana 'aʻole e hookaawale ia i ka hooulu ana o kaʻaoʻao loa. Ka mea, e:

• myalgia;
• pōniuniu;
• hyperthermia;
• drowsiness;
• ka luaʻi;
• headache;
• diarrhea;
• arthralgia;
• hypertension;
• umauma eha;
• thrombocytosis;
• tachycardia;
• hypertensive hoʻoponopono ulia;
• convulsions;
• steatosis;
• e hoohaunaele ana i ka nui o AST, Alt i loko o ke koko;
• erythrocyte germ aeea aplasia;
• eczema;
• angioedema;
• ili lapuwale ia a me ka maneo;
• asthenia;
• hives, redness a me ke ahi ma ke kahua o ka hooponopono;
• hyperkalemia;
• ka ho'ēmiʻana o ke kumuʻiʻo lehulehu ma ka wai koko ferritin;
• hyperphosphatemia.

Erythropoiesis stimulants ma haʻuki

Nei, pinepine hoʻohana lāʻau ' "Epovitan" (recombinant kanaka erythropoietin). Na keia mea paahana Ua pinepine hoʻohana 'ia i loko o haʻuki (hana pāʻani, bodybuilding,' auʻau, biathlon). I aku la o hoomakaukau haʻalele no ka biosynthesis oʻulaʻula koko keena, i ka huli hele aku ai i ka hua i loko o ka maʻiʻo o ka o oxygen no pa alima ka leo o ke koko, a, nolaila, i ka hoomahuahua i loko o ke koko o oxygen nona iho, a O ₂ haawi i nā loko a me nā'aʻaʻa. Kēiaʻano papa hana o ka hana maoli ka aerobic hoomau ana o ka 'âlapa. Ua mālama A like ai ka wā nooaai ka 'âlapa i loko o ka midlands, kahi o ka nele o ka O ₂ i loko o ka lewa ke kumu o ka hooulu ana o ka hypoxia, a ma ka huli haʻalele no ka biosynthesis o endogenous erythropoietin. e hoʻohana 'ia EPO hoomakaukau ana i ka hui pu ana, me ka insulina, ulu hōmona (GH, somatotropin) a me ka stanazolol.

Excessive, kipi 'ana o "Erythropoietin" lāʻau i loko o haʻuki hiki i ke koko clots i IeAUPIIe, IAa IO hiki aku i ka make. Huai ae recombinant EPO ka loa paʻakikī, no ka mea, ka mea kemikala i huiʻia nā hale a mea'ālike i kona physiological Analog, no laila, i kēia biosoedinenie nō illegally hoʻohana ma kiʻekiʻe-hana haʻuki like doping.