"Clopidogrel": analogues, hoʻohana, manuale, kuai

Ma kekahi wahi, i hiki, kauka i hoakaka ia ka lapaʻauʻia "Clopidogrel"? Na Ke Kumu no ka hoʻohana 'ana, analogs, hoʻokuʻu palapala, haku mele' ana,ʻaoʻao 'ole a me nāʻikepili no ka hana ana i keia, e lapaau e hōʻike ma ka au mamuli o keia Haawina. Eia hou, oe e aʻo i ka waiwai o ka lāʻau a me nā mea maʻi manao e pili ana ia.

Release palapala a me ka haku mele 'ana

oe ke kuai i ka lāʻau "Clopidogrel" Ma ka palapala? Alakaʻi ai ia mau moʻolelo i ka lāʻau 'ua hookuu i loko o ka palapala o ka papa, a i kapa komo iā ia me ka manaʻoe kūkulu ka penaʻana. I kekahi blister he 14 apana, ma ke kae - 14 a 28, i loko o ka pepa laulau - 1 a me 2 o na papa a me ka lapaʻauʻia. I ka papa kuhikuhiEʻeleu 'Oponopono mea clopidogrel ma ka hydrogen sulphate palapala. Ke kākoʻo eiiiiiaiou i loaʻa ma loko o ka lāʻau hoʻomanaʻo nā anhydrous lactose, makanekiuma stearate, pregelatinized pia, hydrogenated o Diosekouro ka aila, polyethylene glycol 6000 a me ka microcrystalline kelulose. Film ka penaʻana, a kapa komo iā ia papa oia hoi o ka titanium'okikene lua, hypromellose, Aluminum lacquer (ma muli o ka kalameaʻai Ponceau 4 R), a me ka polyethylene glycol 400 a me 6000 hoʻokō medicament 'Clopidogrel' (kumukuai, e e hōʻike ma lalo nei) i kekahi lei o drugstores, akā, wale ma ke alo o ka kuhikuhi.

pharmacological ano

I lāʻau lapaʻau, hoemiia platelet aggregation e poloʻai pule ma nā agonists. Hana ka lapaʻauʻia "Clopidogrel" (aʻo no ka hoʻohana 'ana, mea kuai, hōʻike manaʻo, a me ka iho o nā pono keia mau mea' ike i loaʻa ma na mea he nui 'inikua punaewele, a hōʻike mai iā ia i loko o keia pepa) no ka, elua no hora, i kā mākou ka hoʻokōʻana hoike no 4-7 lā ma lalo o kaʻano o ke komo 50-100 mg no ka lā. Antiplatelet ia mau ma waena o 7 i 10 mau lā ma ka lōʻihi like 'ole o ke platelet ola.

Pharmacokinetics

Ma hope o moʻolelo hooponopono o ka lāʻau "Clopidogrel" (75 mg - maʻamau mahele lāʻau) ua hoʻomaka koke ke kemu, mai ka gastrointestinal'āpana, a me ka lehulehu i loko o ka hapa wai o ke koko ua mahuahua kānaka, akā, ma hope o 2 hola, a hiki i ka 'ilikai a hiki ke nānā' (0.025 g. / L).

Ua Ua nui metabolized ma ke akepaʻa. Ke nui metabolite Ua AEeOEXAaI derivative o ka carboxylicʻakika (ka hola 85% e hoʻomaka mea ai hoʻolahaʻia i loko o ka wai koko). Ka awelika i kā mākou lehulehu ma hope o ka puana hoʻohana "clopidogrel" He 3 mg / l, ka mea hiki ke malama hoʻokahi hola ma hope, inu.

ʻeleu waiwai a me ka metabolite irreversibly e paa ana i ka wai koko nā polokina. Palapala koeʻoleʻana.

Ma hope o moʻolelo hoʻoponopono o ka 14C-i hiki ke "clopidogrel" kokoke hapalua o ka mahele lāʻau akaka ma ka urination, ma kahi o 46% - na faeces ma 120 hola. T1 / 2 o ka papa kuhikuhiE metabolite - 8 hola.

Saturation metabolite na manawa he nui nā mea maʻi ma hope o hiki 75 makahiki o ka makahiki, i kēia 'aʻole e hoʻololi i platelet aggregation, a kahe ana ke koko manawa.

Ke koko wai koko i loko o loa hakuʻala lehulehu o ka metabolite mea mai ka 5 a hiki i 15 ml / min, no ka mea hoi, i ka wa o ka awelika maʻi oolea o ia mea 30-60. I loko nō o ka mea i ka inhibitory kanawai i loko o nā mea maʻi me ka adenosine diphosphate -ʻonou platelet aggregation i hoemi, e hoomahuahua ae la lakou kahe ana ke koko manawa, e like me ka pono me ka ola nāʻaʻa.

hoike

Nei anei oe i ka ike, no ka mea, i hana i ke kauka i hoakaka ia i ka lapaʻauʻia no nā mea maʻi i "Clopidogrel"? Analogs, a hoolilo iho la i ka medicament no ka Kāohiʻana o thrombotic complications o ischemic hahauʻana, myocardial infarction a me kaʻike ākea arterial occlusive maʻi. I ka wā hoʻokahi lapaʻau me ka acetylsalicylicʻakika a "clopidogrel" i hōʻike i Kāohiʻana o thrombotic complications, a lilo ia i kumu o ka huʻi coronary maʻi pale.

Contraindications

'Clopidogrel' (kuai i keʻena kūʻai lāʻau lapaʻau Moscow māhele mea e pili ana 510 rubles) e pili loan me:

• hypersensitivity;
• huʻi kahe ana ke koko;
• haemorrhagic maʻi pale ;
• loa hepatic hoʻopilikia;
• outpouring intracranial pathology a predisposing i ke kūpono 'ana o ke kahe ana ke koko (akemāmāʻeho, exacerbation o peptic ulcer, hyperfibrinolysis, tuberculosis);
• lactose deficiency (no ka laʻau heluna 'ano apau loa i loaʻa ka waiu kōpaʻa), hereditary galactose intolerance, malabsorption maʻi pale monakō koko-galactose.

"Clopidogrel": ka hoʻohana a me ka laʻau heluna

Nā papa e like me na kauoha, hiki ke lawe nānā 'ole o ka meaʻai. No ka mea Kāohiʻana o thrombotic hanana i loko o nā mea maʻi me ka ischemic hahau ana a myocardial infarction, kauka i hoakaka ia i kela la i "Clopidogrel" 75 mg. I ka huʻi maʻi, a ua kauoha aku ma ka hooulu ana o ka mea nui ischemic necrosis o ka naau Muscle, lapaʻau E e hoʻomaka 'ana, mai ka lā mua. Inc me ka hoʻohana 'ana o "Clopidogrel" - i hou aku 35 lā. Nā mea maʻi me ka ischemic hahau ana e lawe i kēia lapaau i eono mahina. I ka wā o ka thrombotic complications i kupu mai amid ACS me ka hookiekie ana i ka ST Hoʻohana, lapaʻau ua hoʻomaka 'ia me ka loaa disposable hoʻouka mahele lāʻau (300 mg), a me ka mea hou, aole e lawe hou aku i kekahi papa no ka lā. I kā mākou ka hoʻokōʻana ua malama hala na malama ekolu. Ka lōʻihi like 'ole o ka Inc me' Clopidogrel '(analogs a me generics hōʻike mai iā ia ma lalo nei) E ole mamua o hoʻokahi makahiki. E kū'ē i ke kāʻei kua o ka huʻi coronary maʻi pale me ST Hoʻohana elevation pinepine hoakaka 75 mg o ka lāʻau ma luna o kekahi kela la i keia manawa me ka loiloi mua hoʻokahi-manawa hoʻohana o ka hoʻouka laʻau heluna ma ka hui pu ana, me ka thrombolytic Luna a me acetylsalicylicʻakika. Once symptoms hou, e pono e hele ai i ka hoʻohui pū Inc. Hoʻomanawanui iki mai no 75 makahiki o ka lapaʻau ua hāʻawiʻia me ka hoʻouka mahele lāʻau.

overdose

Ma ka loaa ana o ka lāʻau i loko o nā māhele nui loa paipai, e hoikeike ai ma ka mahuahua i ka kahe ana ke koko manawa, a mahope complications. Ma ia wahi, i hiki, oe e pono kūpono lapaau. Ma ka hihia i ka wa e pono ai i ka hoopoina koke ana o? Iaea o hooloihi ae i kahe ana ke koko manawa, e pono i ka transfusion o TM. Aia mea i maopopo antidote.

Hana kūleʻa me nā ai '

I ka wā hoʻokahi? Eaia o "clopidogrel" me ka warfarin i nā hualoaʻa ma ka mahuahua ma ka kahe ana ke koko ana, i mea aha la keia hui pu ana, ka mahalo undesirable. Ua maoli ka manawa o ke kahe ana ke koko, a ma ka hana ana o ka lāʻau i loko o ka hui pu ana me ka nonsteroidal Anati-hoʻoʻino ai ', aspirin, glycoprotein nā mea kūpale a me heparin.

ʻaoʻao waiwai

Lapaʻau medicament 'Clopidogrel' (mea hoʻohana, ka uku, ke ano o ka hooponopono a me ka laʻau heluna i ho'ākāka 'ia ma ka au mamuli o keia mea) ke alakai i undesirable hopena:

• Koko coagulation'ōnaehana: ma ka mahina mua o ka Inc pinepine e ku oe hemorrhage, hematomas hōʻike; ma ka liʻiliʻi loa - conjunctive hemorrhage; kaʻawale hihia - intracranial kahe ana ke koko.
• hematopoietic'ōnaehana: i pohihihi keia hihia - thrombotic thrombocytopenic purpura, granulocytopenia, anaemia, me pancytopenia, a me ka anaemia aplastic.
• Ko mākou hopohopo'ōnaehana: kēlā wā i kēia wā hou headache, paresthesia, pōniuniu; pohihihi keia - vertigo; kaʻawale hihia - noʻonoʻo huikau a me hallucinations.
• Koko na moku, a me ka naau, pinepine i hana hematoma; kekahi manawa, i ke koʻikoʻi hemorrhage, vasculitis, kuu iho la ke koko.
• Naehana'ōnaehana: epistaxis, bronchospasm, pulmonary hemorrhage, interstitial pneumonitis, hemoptysis.
• Digestive'āpana: diarrhea, dyspepsia, abdominalʻeha, kahe ana ke koko mai ka digestive'āpana, gastritis a me gastric ulcer, ka luaʻi, flatulence, nausea, constipation, retroperitoneal kahe ana ke koko, colitis, pancreatitis, stomatitis, huʻi ake e loaa, hepatitis, māhuahua ake nā'ūhū.
• Musculoskeletal'ōnaehana: arthralgia, myalgia, arthritis.
• Skin: bullous rashes (Stevens-Johnson maʻi pale a me kaʻawahia epidermal necrolysis, erythema multiforme), eczema, erythematous poʻe noʻonoʻoʻole, a me ka lichen planus.
• Urinary System: hematuria, hypercreatininemia, glomerulonephritis.
• Allergic reactions: angioneurotic edema, lāʻau lapaʻau maʻi, urticaria, pseudoallergy naoh.

I ka Inc me keia k kuni ua kākaʻikahi malama, i ua ole ike i ka hopena o ka loaa ana i ka medicament, a like me ka symptom o ka pono anuanu.

Cautions

Medicine "Clopidogrel" me ka lōʻihi mālama nui ka wā e lawe kiʻekiʻe pahiki o kahe ana ke koko ma ka hopena o keʻoki lāʻau lapaʻau uao ai ', hemostatic kāna hana. Ināʻoki kino ua pono, a me ka antiplatelet keia mea nui undesirable, mai ka hooponopono ana o ka lāʻau e e kāpaeʻia no ka hebedoma mua o ka manawa i'ōleloʻia ai o keʻoki kino. Mau malama lapaau i hoakaka ia no ka loa aʻe 'ana o ke akepaa hana, a hiki i hemorrhagic diathesis. Inā na hoailona o excessive kahe ana ke koko Pono e noiʻi i ka hemostatic nenoaiu. Eia hou, i ka pono, e mau kanaka hoʻoponopono i ka hana o ka iaea ooieoeiiaeuiiai ha awina o ke akepaʻa. Mālama nui "Clopidogrel" ua hoʻohana 'ia me ka heparin, NSAIDs, warfarin. I ka hoʻokō 'mana haʻawina i loaʻa i carcinogenic a me genotoxic hopena o ka lāʻau, i ka hou, mai i ka hopena ma luna kalepa ana nona iho.

"Clopidogrel": analogs a me generics

Synonyms (analogs) ai '- he lāʻau nei ke ao hookahi ana a me ka hookahi haku mele' ana. He aha lapaau ke kuapo lapaau "Clopidogrel"? Analogs wa hoomakaukau ia no ka hana waiwai ka kēia: "Kardutol", "Detromb", "Agregal", "Trombeks", "Klopilet" "Trocken", "Plavix", "Plagril", "Plogrel", "Targetek", "Egitromb" "Clopidogrel Teva,".

Kēlā me kēia lāʻau, he okoa ano, no laila, ua aeia ka hoʻohana ma hope o ke kūkā pū me kou kauka wale.

Manao e pili ana i lapaau

He aha kanaka i ka i ana no ka makaukau me "Clopidogrel"? Reviews o ka hoʻomanawanui iki mai ia ia i ka manawa kūpono e hoolilo loa illnesses, aʻoki lāʻau lapaʻau uao ai 'i'āina maikaʻi. Nā mea maʻi e hoʻokaʻaʻike mai kiʻekiʻe efficient hana o ka medicament, ia i ua manao ia nae no ka hiki aku i ka mea e pakiko-ka lapaʻauʻia. Analogues o ka ai ', e kōkua e hoomanawanui i koho i ka mea maikaʻi koho no ia i loko o ka lākiō o ke kumukuai a me ka mea e like ai, akā, i ka manao a me ka laulā o ka hooponopono ana e e waiho i ka hoao ana i ka hoʻomalu.