"Cyclosporine": kuhikuhi no ka ho'ohana. "Cyclosporin A": ke a'o. Kūle'a nā maka i ka cyclosporine

Ma ke ano, he mau waiwai hiki ke uhi i ka ke kelepona hele, a humoral e hoʻonele i loko o ka holoholona kino lawe mai ma T-lymphocytes. He hiki ke ana lawe mai hui, transplants a me ka pono mai pili me hihia hoʻi'ōnaehana paleʻea nenoai. One ua cyclosporin mea he kūlohelohe i huiʻia.

hōʻikeʻano

E wehewehe ana o ka waiwai pili a hiki i ka hoʻopaʻa 'ana i fungal ke kanana nei Tolypocladium inflatum a me ka Cylindrocarpon lucidum. Synthesized o biologically hana Luna e like me cyclosporin A, a pela aku ho'āʻo immunological hana ku e lymphocytic koko keena. Kēia hiʻona mua loaa i loko o ka makahiki 1972 ma kaʻepekema mai "Sandoz" o ka Hawaiian Keʻena. Ua Ua ua loaʻa i ka Nine Inch 'ole o ka cyclosporine'ākilikai lipophilic cyclic endecapeptide me ia i ho'ākāka' immunosuppressive hana.

Ua Ua nānā 'ana i ai' i he e wae ana ma luna o T-lymphocytes uhi i ka ke kelepona hele, a humoral e hoʻonele. Cyclosporin koko inhibits ka? Iecaianoaaiiie o lymphokines, a ho'ēmi i kā lymphocyte haʻawina, akā, i ole ia ma ke kaʻina hana o ka hematopoiesis a me ka hana phagocytes, e hoike ana i ka mea e wae ana o ka hui i loko o ke kino.

laʻau heluna 'ano apau loa

He mea e e pili ana ma ke kini puʻe wale me ka lapaʻauʻia i loaʻa ka cyclosporin, manual. I waena o nā mea a pau, e nā 'ikepili ma luna o ke kala ano o ka lāʻau. Hoomakaukau o keia waiwai hua mai la i loko o ka palapala:

• pahee capsules me ka laʻau heluna o ka 25, 50 a me 100 milligrams;
• kanakaʻona mau moʻolelo pāʻoihana a me 100 milligrams o ka cyclosporin no ml o ka pāʻoihana;
• aila moʻolelo pāʻoihana a me 100 milligrams o ka cyclosporin no ml o ka pāʻoihana;
• noʻonoʻo no ka hana ana i ka pāʻoihana no infusion aaieieno? me 50 a me 650 milligrams o cyclosporin no mililika me;
• maka paka ua a me 500 micrograms no mililika me ka cyclosporine.

Ke kaumaha ma muli o ka hana o ka laʻau heluna palapala e e okoa: no na hooponopono, no ka pahu kui, no ka topical palapala noi.

Ua Ua manaoio aku i ka uku o ke omo o kaʻeleu ke keʻena, i ka hoʻomāhuahua manawa o ka mea kiekie loa lehulehu i loko o ke koko o ka mea hōʻikeʻikeʻuʻuku, a me ka pāʻoihana no na? Eaia i manaoia like paha.

Uluwehi O "Tacrolimus": counterparts

Ma ka mea lāʻau lapaʻau kuai loaʻa nō i ka nui o ka ai 'hua mai la i ka ia mea lāʻau lapaʻau palapala, a me ka hoomakaukau i kekahi i ka ia hopena. Kaʻeleu 'Oponopono i loko o ia mea cyclosporine. Na Ke Kumu no ka hoʻohana ana i synonyms immunodepressorov e manao ana interchangeably ai 'e uhi'ōnaehana paleʻea reactions.

Iwaena o na laau encapsulated i loko o kaʻaeʻae gelatin iwi a me ka wai a pāʻoihana o ka palapala lāʻau "Sandimmun Neoral" hua mai la ma ka Hawaiian mea lāʻau lapaʻau poe "Novartis". Ka mea'ē aʻe ai 'noʻonoʻo paʻi i loko o ke kiʻi i hanaʻia e ka mea mua haku mele' ana me ka waiwai cyclosporin. Analogues e like me ai ' "Cyclosporin hexane", "Ekoral", "Tsiklopren" "Cyclosporin A", hua mai la i loko o ka palapala o capsules a me ke kākoʻo pāʻoihana no na a loaa injections.

Lākou ka papa kuhikuhiE manao - hoemi rejection ma transplantation o na nā loko a me ka iwi ka lolo. Pono ia me autoimmune maʻi, e like me ka mea e hoikeike ma ka pili ana i ka lāʻau "Tacrolimus" olelo ao no ka hoʻohana. Analogs i likeʻano, a me nāʻikepili no ka hoʻohana.

Keʻano papa hana o ka hoʻokō ' "Cyclosporin A" lāʻau

Ma ka naau o ka hana o immunosuppressive ai 'a pau o ka e wae ia ma luna o T-lymphocytes. No koe, a me ka lāʻau "Cyclosporin A". Alakaʻi au mamuli illuminates ka papa kuhikuhiE pharmacodynamic maomeka o ka hana o kaʻeleu ke keʻena, ka mea e hoopaa ana i ka mea loaʻa me ka ho okumu loko keena. Emi? Iecaianoaaiiuo o interleukins a me interferon ho'ēmi i kā ka hōʻike o nā receptors no IL-2.

Medicament "Cyclosporin A" ho'ēmi i kā ka? Iecaianoaaiiie o nā mea'aʻaʻa kuhikuhi ma kona mau keena a me nā'aʻaʻa, a lakou i manao malihini a me ka luku aku. Kēia hiʻona apono 'oe e ho'ēmi i immunological kāna hana, a emi i ka ha awina o autoimmune ka maʻi.

Great ka hoʻokōʻana "Cyclosporin A" ma ka manao o ka allograft. Ke kumu no ka rejection o transplanted nā'aʻaʻa a me nā loko o ka ho'ā hope o ka'ōnaehana paleʻea T aeee ua loaʻa. Ka mea, 'Imi hoʻomaka e e hua mai ma lalo o ka hopena o ka transplantation antigens, a he aha ka mea i ka pakuiia auanei lakou keena, e alakai ana i ko lakou make.

Hana immunodepressora hiki aku ai i ka paleʻana loulou T-aeee a me inhibition o T-lymphocytes ai ka haohao ana i ka'ōnaehana paleʻea reactions. Nolaila, i ka laulā o ka lāʻau "Cyclosporin A" (mea hoʻohana Hōʻike kēia) ia lŘlŘ ma hope o ka suppression o transplant antigens wale. Ma ka luku i ka pilina antigen lāʻau lapaʻau kino Hāʻule maila lākou necrosis o transplanted nā loko keena.

no ke aha pili

Nāʻikepili no ka hoʻohana "Tacrolimus" kauoha no ka hoʻohana ana i ka lāʻau 'ua maheleia i mau waeʻano.

Ka mua o ka transplantation paha transplantation o kona mau pou'aʻaʻa a me nā loko. A lapaau hoʻohana 'ia e pale aku rejection o ka hui, a'aʻaʻa podsazhennogo. Nō kāu, na pakui hoʻohana i kaʻili, naau, iwi ka lolo, maʻiʻaʻai, akepaa, hakuʻala, pancreas. Paha ka hoʻohana a ka lāʻau e hoʻopau rejection ma ka hoʻohana 'ana i nā immunosuppressive konohiki. Ka lua o ka waeʻano mea he autoimmune maʻi i loko o ka nui palapala. Kekahi hope paha i hoakaka ia no ka mea haʻahaʻa ka hoʻokōʻana o nā ai '.

Ma ka maʻi, ua hana lāʻau ' "Tacrolimus"? no ka hoʻohana 'ana i nāʻikepili a me ke aʻoʻia allocates huʻi ano o ka atopic dermatitis a me ka neurodermatitis, hoike ana mai o ka psoriasis, rheumatoid arthritis, a me ia e loli ai na ami uuku e wela ai. Hiki ana ma ka uveitis ma ka waena a me ka hope loa o ka maka, i ka wa wela ai choroid a me ka retina, a me nephrotic maʻi pale a me ka hōmona-gormonoustoychivoy ano.

komo lula

Lāʻau lapaʻau ua paipaiʻia ma lalo o 'inikua hooponopono i loko o ka haukapila wale. Nō kāu hoʻohana na palapala noi a intravenous drip, eia nae koho ua haawiia mai e loaa ku una pāʻoihana a me capsules.

Tableware, hoʻohana 'ia no ka hoʻomākaukau i ka pāʻoihana no intravenous ka pahu kui pono e i ke aniani, kahi o ka Tewetewe koloriside e pale aku naoh me ka o Diosekouro ka aila.

No ka dilution o ke kiaʻana i kāna hoʻohana i ka physiological 0,9 pakeneka pāʻoihana o ka paʻakai koloriside a 5 pakeneka monakō koko pāʻoihana. Dilution ua hoʻomaʻamaʻa i loko o huliāmahi mai ka 1:20 a hiki i 1: 100, ke kaumaha ma muli o ka hana. Mai i ka lāʻau mālie mai elua i eono hola.

Mua transplanting nā loko a me nā'aʻaʻa hoʻolauna mamua cyclosporin pāʻoihana no ka hola eha i umi hola. E pale aku allergic hoike ana ma ka laua waeia antiallergic lapaau a me nā immunosuppressants. Ma hope o nā pule o intravenous hooponopono o ka lāʻau e ku una palapala noi. Na kela la i keia mahele lāʻau i hoakaka ia ma kou kauka, ia mau manawa ma he umikumamalua hora.

Capsules inu a pau, me ka weheʻana i ka wahī, holoi iho la me ka wai. Ka lāʻau ma ka waiʻona ma mua hoʻohana nāu kekahi i inu i ka wai i loko o ke aniani li ili i. Ka manuale wehewehe i au mamuli pehea e unpack i ka AEeAaOA, a pehea e hōʻike degere i ka pāʻoihana puka 'o ia' ohe o ke aniani hue, i ka mea e pono koho i ka huina akau o ka lapaʻauʻia. ia ma hope o inu i ka pāʻoihana ipu holoiia me ka wai a me ka inu i ka wai, i ka mea, aole lilo o ka mahele lāʻau.

Concomitant hoʻohana ua contraindicated ai 'a me ka grapefruit wai, a ho'ēmi i kā ke kanawai o ka lāʻau, no hoi i hana ole ia e vaccination me ka noho attenuated a me ka sera mai rubella, polio,ʻo Waimānalo, mumps.

laʻau heluna

I ka hoomaka transplanted makua ke komo me ka kela la i keia mahele lāʻau o 10-14 milligrams no kilogram o ke kino ke kaumaha. Mahope oʻehiku i ka umikumamaha lā o ka lapaʻau ua ana ma ka lehulehu o ka cyclosporine i loko o ke koko. Ua Ua 'ole ma o ka uku o ke omo a me ka huli ana i loko o ke kino. Kēia anakahi mea nui ke kanaka hoʻoponopono i mea e pale akuʻaoʻao waiwai, a me ke pale aku io hana kūleʻa me nā ai '. Mahope, ua hoemiia ka kela la i keia mahele lāʻau o ka lāʻau a hiki i 3,6 milligrams no kilogram o ke kino ke kaupaonaʻana, ka mea, ua maheleia i mau hana. Pākōlea wai koko maʻiʻo o ka cyclosporin pela loli aʻe mai ka 110 a hiki i 410 nanograms no mililika me.

Ma hope o transplantation o nā puʻupaʻa loaa medicament i loko o ka mahele lāʻau o ka emi o ekolu i eha milligrams no kilogram o ke kino ke kaupaonaʻana hiki i rejection.

Iwi ka lolo transplantation pono ai ka hana ana o ka pu ana o ka cyclosporine a me ka methotrexate. A mau a mau lā ma mua o ka transplant hoʻomanawanui ua lawelawe iho la no kela la i keia intravenously o mai 2,5 a hiki i 5 milligrams no kilogram kino kaumaha waiwai.

Ma hope o ka hoʻololi i ka iapaau ana o capsules hoʻomaka me ka kela la i keia mahele lāʻau o 12,5 milligrams no kilogram o ke kino paona, a i lawe ia i nā manawaʻelua. Therapies e like ka nui o ka lāʻau 'mau mai ka ekolu a hiki i eono mahina. Ke kiʻekiʻe o ka pono, e emi i ka laʻau heluna a i ka pau 'ana o ka iapaau ana wā.

E hoʻopau i ka huʻi ana hoʻohana mua kela la i keia mahele lāʻau o ka lāʻau, mai 12,5 i 15 milligrams no kilogram o ke kino ke kaupaonaʻana (lawe mau hoʻokokoke mai). He kanalima lā pana aku au i laʻau heluna ka ho'ēmiʻana o elima pakeneka no ka hebedoma, a hala na la elima mahina o ka lawe ana i ka lāʻau hoʻopau. hou lapaʻau "Cyclosporin" medicament lawe i ka hihia o ka hai naoh. Na Ke Kumu no ka hoʻohana 'ana, manaʻo pihaʻi me ka' ike e pili ana i ke ola o ka transplanted nā loko (naau, ake). Wahi a ka 'ikepili helu, hoʻokahi makahiki ia ihoiho kanawalu pakeneka.

Lapaʻau o autoimmune maʻi pono i ka hana e hoʻokokoke i ke koho ana i nā māhele no kēlā me kēia maʻi.

Ma ka loaa ana "Cyclosporin" hoomakaukau manual ia kekahi hana maikaʻiʻole o ka loa uveitis. E pono e hoʻomaka me ka kela la i keia mahele lāʻau o 5-10 milligrams no kilogram o ke kino ke kaupaonaʻana, a pili i ka mea e ho'ēmi i li nui, a normalization o pilikia makapō kuleana pili i. I ka papa o ka lapaʻau mea ekolu i umikumamaono mahina. I loa lesions o ka hoʻohui pū 'ia me ka prednisolone ma ka mahele lāʻau o ka 200 a hiki i 600 micrograms no kilogram o ka hoʻomanawanui kaumaha.

I loa psoriasis kela la i keia mahele lāʻau mea 2,5 milligram no kilogram o ke kino ke kaupaonaʻana, hiki aku ua hana i loko o nā hoʻokokoke mai. Ka laʻau heluna Ua hoomahuahua ia ka 1 milligram no kilogram o ke kino ke kaupaonaʻana, akā, i oi aku mamua o 5 milligrams no kilogram, ina ma hope o kanakolu lā ma hope o ka hoʻomaka o ka Inc,ʻaʻohe hana hou. Ke komo ana ma hope o eono pule ina kanaka mea ineffective.

Nephrotic maʻi pale me ka maʻamauʻaʻa puʻuwai hana i loko o nā mākua, ua malamaia lakou nei, ka hoʻohana 'ana i ka laʻau heluna o ka lāʻau a hiki i 6 milligrams no kilogram kino kaumaha i loko o na keiki - i ka 5 milligrams no kilogram o ke kino ke kaumaha. Ināʻaʻa puʻuwai kuleana pili i ua hihia hoʻi, laʻau heluna - i hou aku 2,5 milligrams no kilogram o ke kino ke kaumaha.

Iloko o ka iapaau ana me ka cyclosporin maʻiʻo i ua hoʻonānā i loko o ke koko wai koko. No ka pākōlea hopenaʻoi loa pono kona lehulehu i loko o ke koko i loko o ka nui o 60-160 nanograms no mililika me.

ka mua na malama ekolu Ma pono e hooponopono o ka creatinine pae i loko o ke koko, lāʻau lapaʻau, e like me ka mea i loaʻa i loko o kēia anakahi i peʻahiʻana i ka hoʻomaka o ka rejection o ka transplanted hui, a me nā konāhua maʻi. No ka poʻe i loaʻa puʻupaʻa e hana pono, ua lawe mai ka Ikepili hookahi no kela umikumamaha mau la, ina he mau aʻe 'ana, creatinine inideka ua anaia mai ka manawa i na lāʻehiku. A hiki i ka lehulehu o ke anakahi ma mua o 200 micromoles no hano no nā mākua, a ma luna o 140 micromoles no hano no na keiki ke lilo aku abolition o ka lāʻau.

Aie i ka mea hikiʻawahia ole o ka lāʻau ua lawe mai papa'āweʻaweʻa kemika ka mālamaʻana o ka maʻiʻo o ka bilirubin, urea, amylase, makanekiuma a me ka potasiuma Ion i loko o ke koko, ake nā'ūhū ua nānā '.

Rheumatoid arthritis mea he nui ano iloko o ka mua eono pule malamaia lakou nei, ko lakou hoomakaukau ana "Cyclosporin" ma ka mahele lāʻau o 2,5 milligrams no kilogram o ke kino ke kaupaonaʻana, i ukali ia e lapaau i ka mea i kela la mahele lāʻau e ole oi 4 milligrams no kilogram o ke kino ke kaumaha. I ka poe ilihune tolerability o ka medicament mea hiki ke ho'ēmi i kona nui a hiki i ka palena iki pono ka mahele lāʻau. Paha he huihui 'ana o "Ciclosporin" lāʻau me ka uuku nui o corticosteroids a nonsteroidal Anati-hoʻoʻino ai'.

Loa ano o ka atopic dermatitis ua malamaia lakou nei, ma kela la i keia mau hoʻoponopono lāʻau i loko o ka mahele lāʻau o 2,5 milligrams no kilogram o ke kino ke kaumaha. Inā he mea ole kanawai ma hope o umikumamaha mau lā i hoakaka ia i kā mākou kela la i keia mahele lāʻau - 5 milligrams no kilogram o ke kino ke kaumaha. Inā he mea hou i loko o ka moku'āina, ka mea, ua pono i ka gradual ka ho'ēmiʻana i loko o ka mahele lāʻau o ka lapaʻauʻia.

Penei ka hoʻohana 'cyclosporine maka? maka kulu

Immunosuppressive konohiki i ua hoʻohana ma ophthalmology no ka iapaau ana o ka maka maloo. No kēia mau mea, cyclosporine. Eye kulu kona Contents (0.05 pakeneka) e-market ma lalo o ka tradename "Restasis".

Kēia Agena no a hiki i ka pae o ka laau i hoʻohana, e hoomalu aku i ka cornea a me ka humidification. Hua mai makaukau i hookahi mahele lāʻau o 0,4 milligram ehiku huewai o ka maʻiʻo ma kekahi mililika me ka pāʻoihana 500 mg oʻeleu 'Oponopono.

He aha pharmaceuticals hōʻike cyclosporine? Eye kulu paka Anati-hoʻoʻino, immunomodulatory hookoia, inhibits ka? Iecaianoaaiiie o lachrymal secretion ma maloo keratoconjunctivitis.

Pehea e hoʻohana i ka lāʻau "Restasis"

Tuamotu hoʻohanaʻano "Restasis" i loaʻa cyclosporin. 'Āpana alakaʻi ia kekahi eyedrops e lulu mua i ka hue i loaa i kekahi homogeneous opaque keʻokeʻo emulsion. Wale lailaʻoe e hoʻomaka i ka haʻaheo lāhui paka ua i loko o ka conjunctival sac o ka hoʻomanawanui ka maka. Kēia ke kaʻina hana no ua lawe mai palua i ka lā,ʻo kēlā kanaka he umikumamalua hora. I ana i ka lāʻau 'e ole hoʻopā aku i ka lihi o ka maka mucosa hue, e pale aku ingress o ka maʻiʻaʻai ma ka pāʻoihana. He nui no ka hoomanao i kou pono e hoʻohana i ka lapaʻauʻia koke ma hope o ka weheʻana i ka hue, pāʻoihana ka i koe, ua i hoʻohana 'ia, ka mea, ua hoʻohana' ia.

No laau "Restasis" lāʻau wā ua hoʻokomoʻia ka leo nā aniani kaulona. Ua wehe 'ia mamua, e hana i ka pāʻoihana, a ua hiki ke reinserted ma hope wale umikumamalima minuke.

Ka hoʻohanaʻana i cyclosporine no na holoholona

I kēia manawa, kēia immunosuppressive Agena ua hoʻohana pū no ka iapaau ana o autoimmune ka maʻi i loko o na ilio a me na holoholona.

Initially wale no ka poʻe hoʻohana cyclosporine. "Sandimmune" - aila pāʻoihana i loaʻa ka keia hui, ka wā hoʻohana 'ia e kekahi mau hoʻomanawanui iki mai, kena ae la i kekahi lehulehu o kaʻeleu' Oponopono i loko o ka wai koko.

Ua hana hou kēia palapala laila - ultramicronized cyclosporine ( "Neoral"). Ua kumu i ke kahua o ka microemulsion loko o ka AaOIeIOUIeXAOAaIN me ka wai. Ua alakai aku ai i ka hana i loko o ke omo a me ka bioavailability o ka lāʻau 'i kū'ē i ka aila pāʻoihana i mea ole pono no na holoholona.

Mea nana i hana o ke kauka holoholona ano o ka lāʻau ua noʻonoʻo i ka poe "Novartis". I ae ia lāʻau Ua hoʻokuʻuʻia i loko o 2003 i kapaia "atopic", ka mea, ua manao ia no ka iapaau ana o ka atopic dermatitis i loko o na holoholona. A hiki ia manawa, informally immunosuppressants hoʻohana no ka transplant hakuʻala nā pōpoki a me nā'īlio no ke kokua ana i symptoms o hoʻoʻino keʻano o ka hanaʻana.

Symptoms o atopic dermatitis ana hōʻike i opiopio ilio a me nā pōpoki ma waena o nā makahiki o ka eono mahina i ka makahiki ekolu. He He maʻi maʻi wehewehe aku ma recurrent relapses. Inā ua nele lifelong hoomakaukau i loaʻa ka cyclosporine e e hana. Na Ke Kumu no ka hoʻohana no na holoholona "atopic" 'o ia hoʻi kuhikuhi mai la lakou a hiki i ka manawa kūpono o ka hoʻohana' ana i ia i ka lōʻihi manawa ka pono a me ka maluhia.

Me ka i ka wā hoʻokahi aiʻai ana a me ka lapaʻauʻia i ka loli ma ka omo, ka mea, ua waiho, e lawe i ke koʻi i loko o, elua no hora hope paha ma muaʻai.

Mawaena o ka unintended hopena o ka hoʻohana 'ana i ka lāʻau' loa olelo i paewaewa ma ka digestive'ōnaehana, akā, ka mea i hōʻike 'ia i loko o ka maʻalahi ano. Otherʻaoʻao waiwai i na hoailona o ka hypertrichosis, gingival hyperplasia a me hyperplastic dermatitis. Ma ka hoemi i ka laʻau heluna o ka lāʻau 'o kā lākou gradual nalowale.

Loaa ana cyclosporin ho'ēmi i kā ka ulu a me ka ulu ana o staphylococcal nā mea palahēhē a me pathogens malassezioznogo dermatitis, ma ka pākōlea mahele lāʻau aʻole i hoʻokō 'ole' hakuʻala, hypertension, ho okumu o neoplasms. A pau kēia mau kūʻiʻo hoike haahaa kamepiula o complications iloko o lōʻihi-makahiki lapaʻau o atopic dermatitis i ka ilio.