"Fosinopril": olelo ao no ka hoʻohana. "Fosinopril": nāʻikepili no ka hoʻohana 'ana, maoli counterparts

"Fosinopril" mea he inhibitor o angiotensin hoʻololi ''ūhū. Ka lāʻau 'Ua hypotensive hana, ka mea hiki ke hoʻohana' ia no kiʻekiʻe ke koko, wale, a me ka luna 'Inc. Eia kekahi, o ka medicament ka lawe natriuretic, vasodilating a me cardioprotective hana, ka mea, ua hoʻohana 'ia i loko o ka hui pu ana me ka' ē aʻe ai 'i ka iapaau ana o ka naau ole.

Pharmacological waiwai "fosinopril"

E hoomakaukau ai "Fosinopril" i loko o ka kino i ke ano o ka hana metabolite mea e kaumaha ana kanawai ma angiotensin hoʻololi ''ūhū. Ke k ho'ēmi i kā ka uku o ke kahua o ka angiotensin 2, normalizes ka systemic ke koko, maikaʻi ia ma luna o nā ipu koko.

Angiotensin hoʻololi ''ūhū ha awina ma 10, 20 a me 40 mg lāʻau ua kūpono kou hoemi ma ka awelika no 7 hola (i wikiwiki aku 2 hola, akā,ʻaʻole hope ma mua o 12 hola ma hope o ka lawe ana i ka ka lapaʻauʻia). Iloko o ka lā ka mea, ua hoemi ia 7-15%.

"Fosinopril" papa ae, e hookaawale ia myocardial hypertrophy a me dilation o ka ventricle hema, ma ke alo o ia mau olelo he hoʻonui i kā lākou hoʻopau. Ke k inhibits ke kahua o ka aldosterone a ua lawe mai i loko o ka adrenal glands, maoli i ka ha awina o ka kallikrein-kinin'ōnaehana, stabilize ka bradykinin ka maʻiʻo i loko o nā'aʻaʻa a me ke koko. Manawa Inc me ka nānā 'ana ma o ka hoʻohana' ana o "fosinopril", piʻi pū liberatiou waiwai i ka hoʻoikaika 'ana i ke koko lako i nā puʻupaʻa, i natriuretic, vasorelaxant hana. Ke medicament ho'ēmi i kā iecaianoaaiiuo arginine vasopressin a me endothelin-1, a hana vasoconstrictor.

Ma ka hoemi i ka'aloʻahiʻa (diastolic, systolic) e e ulu, a me ka postural orthostatic tachycardia naoh 'aʻole e hoʻololi' ana i BCC. Aia nō i nā loli i loko o ka reflex hana o ka myocardium,ʻaʻa puʻuwai a me ka cerebral koko pele. Aia i ua ole 'aʻe' ana i ke koko lako i kaʻili, na nā loko, skeletal Muscle'aʻaʻa.

E like me ka manual, "Fosinopril" hoʻohana i loko o ka hookahi mahele lāʻau, i ka hypotensive hana i ua loa haʻi ma hope ma kahi o elima hola. Ke kūpono ole, ua paa ia no ka lā, a leie aku oe, e malama i ka maʻamau ke koko, kiko'î. No ka hōʻike 'ana i ka mea i kā mākou e hiki ia ua koi' ia e ua hala kekahi mau pule.

Ma lapaʻau "fosinopril" hypertension ke hoʻoikaika 'ana i ke kino o ka pane ana i ka kokololio emi ana i loko o ke koko, systemic. I ka hui Inc me thiazides a "Fosinopril" mea e akaka oi hai antihypertensive haʻawina. Inā pono, ana i ka "fosinopril" i i hoʻomōhala i ka maʻi pale, ia mea,ʻaʻoleʻo ia i loko o ka hihia i ka wa a ka ke kāpaeʻana ua i dramatically. E hoomakaukau ai? Ienoai aa ka hoʻomanawanui ka wā paakiki e kahe ana o ke ano maʻi naʻau e hemahema, e like me ke kino o ka pane i physical stress.

E pili ana i ka h ÷ ike ike ana o mutagenic a me ka genotoxic waiwai i loko o ke au o ka iapaau ana "Fosinopril" ka lapaʻauʻia alakai IeEeAUUXAAaO lākou e kaawale aku. Eia naʻe, no ka pono o ka cytotoxic nā māheleʻo ia i kekahi mau kāna hana pili me ka chromosomal aberrations. Haʻawina i mālama 'ia ma kaʻiole a me nāʻiole hōʻike i ka kela la i keia mahele lāʻau i oi aku 400 mg / kg aʻole i symptoms o carcinogenicity. Ma muli o ke kiekie nā māhele i kane iole hoʻokomo akula pinepine ikea lipomas. Kela la i keia nā māhele o ka lāʻau i ka 60 mg / kg i ka iole i ole i kāna hana pili i ka manaʻo o reproductive kuleana pili i. Wā lawelawe medicament hapaiʻiole (kela la i keia mahele lāʻau mai i 400 mg / kg no ka lā) a me nā 'Olu (kela la i keia mahele lāʻau 40 mg / kg) ana intoxication, lāʻau he kūlana maikaʻiʻole i ka papa o ka hāpai keiki.

Omo ia hoʻi, "Fosinopril" hoʻohana Noi wehewehe aku i na mea, ma muli o ke emi nuiʻai. By kumu o ka mua-alahele pūnao bioavailability iki (36%). "Fosinopril" hydrolyzed, i kēia kaʻina ia lŘlŘ i loko o ke koko, ake a me ka gastrointestinal iwi ma muli o ia kona manaʻo fozinoprilat i hanaʻia, i mea he kaila metabolite. Ua loaʻa ke i kā mākou kiʻekiʻe o ka lapaʻauʻia i loko o ke kino ma kaʻawelike ekolu paha hora ma hope o kona palapala noi. Hapa-ola ia lŘlŘ 12-15 hola. Palapala a me ka wai koko Ua kokoke piha - mai i 98%, mea liʻiliʻi o ka buke o ke haawi aku.

Ka lapaʻauʻia aʻole i 'aʻe i nā palena placental a me ke koko-lolo o ke'ākeʻakeʻa mai, i ka wā o ka iapaau ana mea i loaʻa i loko o ka umauma o ka waiu. I cirrhosis (kanakaʻona mau, biliary) ua hoʻemiʻae, hydrolysis puka mai lohi. I kaʻaʻa puʻuwai insufficiency ia lŘlŘ hoʻohuikau diatsidnyhʻeleu metabolites excretion, lāʻau i loaa i loko o ke kino. Ke hoʻohana no dialysis, e wehe i ka lāʻau o ka meaola "Fosinopril" manual ka hōʻike 'ana mai i ka hana a' aʻole e paka i ka makemake hopena.

Nāʻikepili "Fosinopril" hoomalolo

"Fosinopril" i hoakaka ia no ka naau a me ka hoʻokō 'ole' hypertension. Ma ka hihia mua, i ka lāʻau o ke kumu no nā Inc, i loko o ka lua o ka luna 'ua hoʻohana' ia no Inc a me ka monotherapy.

Iapaau ana me "Fosinopril"

Nō kāu, papa e inu ana i kekahi a me nā manawa i ka lā i loko o ka ia manawa. Ma ka iapaau ana o ka hypertension paipai mua 10 mg o ka lāʻau, a me ka hope - 20-40 mg. Ma ka hui lapaʻau, koe wale no ka wā "fosinopril" ua hoʻohana 'diuretic, lawe 10 mg o ka lāʻau. Ma keia hihia, ana ka mālamaʻana o ke koko,, ke i kā mākou hiki mahele lāʻau o ka lāʻau, he 80 mg no ka lā. Inā i ka lāʻau, kekahi mahele lāʻau 'aʻole e ka palua ana o ua skipped. Lapaʻau nā māhele hua mai la i ka hoʻohana 'ana i na mea paahana e waihoʻia kekahi kauka hiki ole lawe i ka nui a uuku dala o ka lāʻau a me ka hoomahuahua i kona alapine (frequency) o ka hoʻohana' ana, aole hoi e hiki ke hana i ka ke kāpaeʻana "fosinopril" me ke kuka mau i ke kauka.

Ma mua o ka lawe i ka lapaʻauʻia "Fosinopril" e manual e waiho ia oe hoao i ka degere o ka mea ulu i loko o ke koko,. Ma ke kauoha o ka iapaau ana i loko, no ka mea okoa lapaʻau ana, ke kauka e mau kanaka hoʻoponopono i ke ano o ka hoʻomanawanui.

E loa kń i ka pilikia o ka? Acaeoey o ka haumāna hypertension, he uuku mahele lāʻau ua paipai i bedtime. Antihypertensive lapaʻau ana i nā lā ma mua o ka hoʻomaka o ka Inc, "fosinopril". Inā ua hana mua oe diuretic Inc mea e emi i ka pilikia o symptomatic hypotension,? Ee loli a me ka electrolyte koena, diuretic me ka nui loa emi i ka mahele lāʻau, ma kekahi hihia, e lawe ana i ka lāʻau 'loa (no ka 4-7 lā ma mua i ka mua mahele lāʻau "fosinopril") pau ana.

Ma hope o myocardial infarction Inc o ia hoʻi, "Fosinopril" aʻo ma ka noi e leie aku oe, e hoʻomakaʻekolu lā ma hope. Ma lapaʻau pono regular ana o ke koko, a me ponopono lauana oʻike ākea koko (kulana kupono ma mua Inc, ka pāʻana o loko o 3-6 mahina o Inc i loko o ka wā e hiki mai hōʻoia ua hana keia makahiki, oi pinepine ka mālamaʻana i e pono ai ka wā he kiʻekiʻe pahiki o ka hanana o ke neutropenia). A eia hoi, he mea pono e kū kino ke kaupaonaʻana, e kaha i ke kūlana o nā puʻupaʻa, a creatinine pae, potasiuma i loko o ka haku mele 'ana o ka wai koko kumuʻiʻo, koko urea naikokene. Iloko o ka iapaau ana e pono e hahai i kaʻai.

Hoʻomanawanui iki mai kona malignant hypertension he pūʻulu ka lapaʻauʻia mahele lāʻau i nā hoomahuahua ae la lakou (na po), e noonoo pono i ka mea hou i loko o ke koko,, oiai o ka hopena, e e maximized.

Contraindications i ka loaa ana "Fosinopril" lāʻau

I ka ka lanakila o na papa io "Fosinopril" nāʻikepili no ka hoʻohana i manaoia ka poʻe me contraindications. Ua hoʻohana 'ia i ke k ma ka hihia o ka hypersensitivity i kona eiiiiiaiou, a no kekahi hana i alu ai'. Ka lapaʻauʻia i hoakaka i nā mea maʻi kanaka kahiko, malalo o ka 18 makahiki o ka makahiki a me ka hapai wahine, breastfeeding wahine. Contraindication uaʻelemakule e kahe anaʻaʻa puʻuwai ole. Contraindications nā angioedema (idiopathic, hereditary) me ka makana i ka manawa o ke kohoia ana o ka lāʻau ', like me ka poe i ka mōʻaukala i olelo ia hyperkalemia, hypotension.

hāpai keiki

Papa "Fosinopril" manual ua papa i ka hana i hāpai keiki, no ka mea, ai 'o kēia' ano hiki ke alakai i developmental kāna hana, a fetal make.

Inā ka hāpai keiki o ka wā o ka manaʻo o ka Inc koi kokololio abolition o ka lāʻau. Ma ia hihia, he ultrasound study, e kuhikuhi i ino ai i ka fetus.

A keiki kona makuwahine i hana i hāpai keiki "fosinopril", hiki ke loaʻa hyperkalemia, hypotension, oliguria. Inā ulu oliguria, ia mea nui ia i kākoʻo no kaʻaʻa puʻuwai perfusion a me ke koko, kulana kupono paha mau. Inā ka hakuʻala hana, a ma ka mea e normalize ke koko, mogzhet e hana transfusion a dialysis.

Hoʻokau 'ia ka hoʻohana' ana o "Fosinopril" hoomalolo

I ka apuepue lede autoimmune mai e lawe i ka mooolelo o ka lākiō o ka pomaikai a me ka Loaʻaʻia ka pilikia o ka iapaau ana o ia hoʻi, "Fosinopril". Na Ke Kumu no ka hoʻohana 'ana, pane hōʻike i ka pono, e noonoo i ka ka pilikia a me ka pomaikai ma ka kēia hihia.

• coronary artery maʻi;
• ke alo aku o ka hoomanawanui transplanted hakuʻala;
• gout;
• mimikō;
• angioedema mōʻaukala;
• maʻi ano o obstructive akemāmā maʻi;
• hyperkalemia me ka 'inideka oi aku ma mua o 5.5 mmol / H;
• desensitization;
• cirrhosis;
• obstructive loli, pu e hoʻopōʻino koko outflow mai o ka naau (aortic stenosis, mitral);
• loa naʻau ole;
• ʻai, hoomaopopo ana i ka kaupalenaʻai ana o ka paakai maʻiʻo 'ole o ka palena iki nui o ka paʻakai i loko o ka ai hoopauia;
• hyponatremia;
• leukopenia, thrombocytopenia;
• kekahi kaʻina hana (dialysis, anesthesia) hana;
• atherosclerosis, a e loli ai i ka lalo lala;
• dehydration;
• ʻaʻa puʻuwai ole creatinine luna 300 pmol / L;
• wa e poohina ai;
• hepatitis;
• pilikia a me ka lolo a me ka coronary koko;
• stenosis;
• kumu ma i ka hōʻemiʻana BCC.

ʻaoʻao 'ole mai o ka "Fosinopril" lāʻau

Available i ka medicament "Fosinopril" hōʻike manaʻo, a alakai noonoo i ka likelihood o ka ulu kekahiʻaoʻao ona. Kānāwai i loko o kāna hana o ka hematopoiesis'ōnaehana a me ka mea'ōnaehana mānowai koko kahua. Hiki loli o ka'emi'ōnaehana, digestive nenoaiu, i ka ulu ana o ka hana ana makaukau. Kekahi nā mea maʻi i loli ma ka keʻena hoʻokolohua kiko'î a me adverse hanana, i ka hoike ana o ka loli ana i kaʻili, musculoskeletal nenoaiu. E ana ka haunaele ma ka ÷ naehana hanu a me ka urogenital kahua. I waena o nā adverse kino reactions - hyperhidrosis, ke kaupaonaʻana poho, ka luaʻi, kuni, angioneurotic edema, kino ulu i loko o infectious keʻano o ka hanaʻana a me hoʻoʻino keʻano o ka hanaʻana i loko o lymph aka wahi, lymphadenopathy, worsening o ka gout. Kekahi pilikia i lapaʻau E e hoike ai i kou kauka. Higher pilikia o adverse hanana pili me ka hoʻohana kūpono 'ole o ka ai'.

Overdose "Fosinopril" lāʻau

I lāʻau lapaʻau, "Fosinopril" pane hōʻike i ke ola ana pahiki o ka overdose like me ka hopena o ka loa i ka paipai mahele lāʻau. Overdose ua pu ma huʻi hoikeana o ka hypotension,ʻaʻa puʻuwai e hemahema, nanea ana, kŰia, bradycardia, mai ka pioloke o ka wai a me ka electrolyte koena.

Paka i kekahi mahele lāʻau ka ho'ēmiʻana a hoʻopau o ka medicament holoi opu, a haawi aku i ka hoʻomanawanui, e inu i ka sorbent. , He mea nui i ka poʻe lawe i ka papamoe kulana, ia mea pono e hoʻokō ana nona ma hoʻoulu i ka BCC. Ua hoi pono symptomatic Inc. Hemodialysis ma keia hihia, aole ia e haawi i ka makemake kanawai.

Uluwehi O AaOIeIOUIeXAOAaIN "Fosinopril" hoomalolo

Ka pahiki o ka hanana o ke hyperkalemia lani kiekie loa ia ka hoʻohana 'ana ai', i ua haku o ka potasiuma paakai ae pani ai, cyclosporine, supplementation me ka potasiuma, potasiuma-loa lakou e minamina diuretics.

Ke kanawai o ka lāʻau i hoike nui pono ma ka hoʻohanaʻana i nāʻano, i ka hypotensive kanawai, a me ka waiʻona. A nawaliwali kanawai ma mua o manao ia mea i loaʻa i ka hopena o ka pono o ka waiwai i haʻalele i ka renin-angiotensin-aldosterone'ōnaehana, estrogen, NSAIDS a me sympathomimetics. Ma na hihia ia mea e pono ke hoole, eʻae i kēia mau kālā a puku "Fosinopril". Analogs i waeʻia e ke hele kauka. Ma ka manawa kūpono o ka hoʻohuiʻia i ka lāʻau a me nā ai 'hiki ke loaa mai ka hoʻomalu.

Analogs, "Fosinopril" synonyms lāʻau

"Fosinopril" i synonyms a me analogues. No ka synonyms no "Fosinopril-Teva", "Monopril." Mai keia pae o ka ai 'he "Fosinopril-OBL», «Fozikard". O na synonyms oe ke koho "Fozinal", "Fozinotek".

A hiki i ka iapaau ana, aole ia e ae o ia hoʻi, "Fosinopril" aʻo no ka hoʻohana ', synonyms a analogs hoonoho hoʻomalu no ka lapaau. Analogs "Berliprilom ',' Renitec '" ramipril "," Moeksom "," lisinopril ". Ikeia analogs hoi nona "Prestarium", "Enap" a me ka "enalapril". Of analogues hiki ke hāʻawi "Tritatse", "Akkupro", "captopril". Hiki lapaau hoʻohana 'ana i ka "Palapala" a me "Prenessa".

Inā ua papa i ka hana o ka lapaʻauʻia "Fosinopril" aʻo no ka hoʻohana ', analogs a synonyms koho hoʻoholo hoʻomalu.

Reviews o ka la hoomalolo "Fosinopril"

He nui ke koho i ka akau Anati-hypertensive ka lapaʻauʻia i ka hoomanawanui, e lawe i ka mooolelo o ka 'o kona kino. Inā "Fosinopril" lāʻau kupono kanaka, ua hoemiia ka pono i ka manaʻo koikoi, a me kaʻaoʻao ona mai i kānāwai. E like me ka nāʻana, he mea he noaaeeecaoee o ke koko,, iaono? Ienoai nohona ola. Inā adverse reactions o ke kino, a e malama, ka mea i mehana, ka hapanui e hoao ei haunaele, flushing, cough.

High ke koko, ke alakai i ka pili me ka poho i ka nui nā loko mea pilikia, pela oe Pono manawa e e ka mea e pono ai Inc, a heluhelu i ka hōʻikeʻano o ka lapaʻauʻia "Fosinopril" analogues, no kaʻike a me nā maikaʻi kēia 'ike.