Ka lāʻau "Carboplatin": aʻo no ka hoʻohana, analogs a me nā hōʻike manaʻo

He aha e puku i kēia lāʻau 'like "Carboplatin"? Analogs o keia k, e e helu 'ia ma lalo nei. Nō hoʻi i loko o nā mea o kēia 'atikala e e hooku iho la ia ike e pili ana i ka pololei ana o ka la dala, kona nāʻikepili, aoao' ole a me nā contraindications.

Haku mele 'ana hōʻike, i ke kinona o ka medicament

Ma ka palapala i loaʻa lāʻau "Carboplatin"? Ka Hookah koi ana i ka hoʻopololei hiki ke kuai me ke keʻokeʻo lyophilized pauka manao ia no ka makaukau o ka intravenous pāʻoihana. Konaʻeleu 'Oponopono mea carboplatin, a me ka hou - mannitol.

Ma ke kuai ana o ka pahu kui kiaʻana i kāna "Carboplatin", ka haku mele 'ana o ka a mākou i hōʻike mai iā ia ma luna, ke hele mai i loko o ka hue ili i i waihoia ma ka pepa'ōpala.

pharmacological waiwai

He aha mea i ka lāʻau "Carboplatin"? Na Ke Kumu no ka hoʻohana 'ana, manaʻo hoike i ka luna''okanikaʻole hui i loaʻa i ke kaumaha metala e like me platinum.

Poe akamai i paipai i keʻano papa hana o ka hana ana i keia mea kökua ka mea ku pono i kona hiki ke hoopaa i ka DNA. E like me ka hopena, i hanaʻia vnutrispiralnye crosslinking kuahu DNA 'ole, a inhibit kona hoʻololi kemikala. A like hopena ia lŘlŘ nānā 'ole o ka halepaahao kalapona pae. It E e hoʻomaopopo i ka hydration carboplatin, a ma ia hanaʻeleu ano o ka lāʻau mea nui ke kua'āina ma mua o ka hydration o cisplatin.

Kinetic kiko'î o ka medicament

Pehea ke ano o na kanaka kino o "Carboplatin" puʻunaue ana i ka waiʻona? Na Ke Kumu no ka hoʻohana hākālia nō ia ma hope o ka hookahi mea, o keia Agena i loko o ka palapala o ka infusion (iv) 60 minuke, i loko o ke koko lehulehu o ka noa (a laila amenable ultrafiltration) a me ka huina platinum emi iho e like me ka mau-pae kumu hoʻohālike o ka mua o ka papa pharmacokinetics.

E hoʻomaka ana manawa o noa platinum-ola o ka hola 2 hola, a me ka maʻi T1 / 2 - 3-6 hola. Ua E hoi e hoʻomaopopo i ka huina platinum ua wehewehe aku e like ka loiloi mua hapa-ola, akā, ma ka hopena-ia hou (ma kahi o ka lā).

Hai hooponopono o ka lāʻau i 4 lā i loko o ka lalani i loko o ke koko o ka hoʻomāhuahua platinum i malama. Mahope o kekahi lā ma hope o ke noi ana o ka lāʻau ma kahi o 85% o ka hana 'Oponopono i loko o ka wai koko ua paa ia i nā polokina kulana.

Pehea o ka hoʻopau o ka lāʻau "Carboplatin"? Alakaʻi koi ana i ka la hoomalolo ua lokoʻano nui puʻupaʻa (30% o ka mahele lāʻau kuu ma unmodified ano).

Ma kānaka cs 60 ml / min, a ma luna o kahi o 65% a me ka 70% o ka hoʻohana metering auoiaea no ka 11 a me ka 23 hola, niioaaonoaaiii.

Mai ka hoʻopau o ka "Carboplatin" i wahi kokoke loa ma glomerular kānana, wale heʻuʻuku lehulehu ike i loko o kaʻaʻa puʻuwai tubules, a wehewehe i ka haʻahaʻa nephrotoxic Loaʻaʻia o ka lāʻau 'i like i ka cisplatin.

Anticancer lāʻau "Carboplatin": hoike

Ma kekahi mau hihia, hōʻike i ka hoʻohana 'ana i ka lāʻau ma lalo o noonoo? E like me ka olelo, ia mea no ka lapaau ana o na kēia mau hikoko:

• ovarian Ka maʻi 'aʻai;
• cervical Ka maʻi 'aʻai;
• germ aeea hikoko i loko o nā kānaka a me nā wāhine;
• osteogenic sarcoma;
• akemāmā Ka maʻi 'aʻai;
• medulloblastoma;
• haanou ana mai o ka ai a me ke poo.

Bans ke ano o ka infusion pāʻoihana

He aha e na contraindications lāʻau i "carboplatin"? I ka hana o keia k ua pāpā inā:

• umauma-e ai ana;
• mea hakuʻala pathologies (e laʻa me, CC emi o 15 ml / min);
• hāpai keiki;
• hypersensitivity e carboplatin a me nā na laau, a me he platinum;
• loa myelosuppression;
• nui ke koko poho, a me ka poe i ike i ka mea hou i hala;
• i kamaliʻi.

No hoi me ka mālama nui keia ka lapaʻauʻia ua hoakaka ia no:

• i nā vaccination;
• lohe hoʻopilikia;
• ʻaʻa puʻuwai kāna hana;
• naau iwi lolo hematopoiesis, a me nā kūlana hope radiotherapy a me ka chemotherapy;
• laua ana o nephrotoxic ai '(e laʻa me, "Cisplatin");
• huʻi nā mea palahēhē o ka mea hoʻomaʻi, fungal a me ka mea koʻohune kumu.

Medicament "Carboplatin": kauoha no ka hoʻohana

Pehea e hana i ka anticancer lāʻau e hoʻohana? E like me ka poe akamai, keia medicament hiki ke pili me ka monotherapy, a ma ka hoʻohui pū 'ia me kekahi' ano me he like ia (e laʻa me, ma ka hui pu ana, me ka "Paclitaxel" hoʻomākaukau).

Ke kaumaha ma muli mea nui, a ma ka hoʻomanawanui ua IIeEeAIEUIeXAIIUEʻeho, kauka hoʻohana okoa dosing "Carboplatin". Ka mea, e haawiia mai intravenously me ka infusion no 17-55 minuke.

Pehea e au e hoʻohana i ka lapaʻauʻia "Carboplatin"? Alakai kuhikuhi mai la lakou i na kēia dosages o keia mea paahana.

• 100 mg / heʻahā like mika hoʻomanawanui kino i kēlā lā i 5 mau lā;
• 300-400 mg / huinahalike mika o ke hoomanawanui, i kekahi manawa, o kela mea keia 4 pule.

It E e hoʻomaopopo i ka wā mawaena ma waena o hooponopono o ka lāʻau, ma ka like ana o ka 100 tausani platelets / mm o a me ka 1.5 tausani neutrophils / mm o, e ia ma ka liʻiliʻi 4 pule.

Ma mua a ma hope o noi ana o ka "carboplatin" hou 'ana i lawelawe ke kinowai like hoʻi me ka hooko ana mai ka lalau wale, diuresis ua koi' ia.

Inā ke hoʻomanawanui i ka wi hematological kaʻawahia a lōpū e Pono e emi i ka laʻau heluna o ka lāʻau a hiki i 26%.

I kaʻaʻa puʻuwai pathologies nunui maoli i ka pilikia o kaʻawahia hopena o ka lāʻau, a no ia mea, emi ka mahele lāʻau ma muli o ka CC pae.

Ma ka kūpuna, e like me ka pono i mua i mālama 'ia ma ka myelosuppressive Inc, e e hoemi ia 22-25% ka laʻau heluna.

Prior e hoʻohana, ka infusion pāʻoihana e hoʻomaka kona pilikia makapō nana i mea e ike ai i ko laila mea i kekahi akā, i loko o kona waihoʻoluʻu a me impurities.

He aha e hui pu he lepo lā lāʻau "Carboplatin"? Na Ke Kumu no ka hoʻohana ana i koi iʻeleu lāʻau pono e nāu kekahi ma ka monakō koko 5% pāʻoihana a me ka paʻakai koloriside 9%. Ma keia hihia i ka malama lehulehu e e 0.5-1 mg / ml.

Ka lāʻau pāʻoihana E e hoʻomākaukau pono ma mua me ka hoʻohana 'ia, mai ka mea i kā mākou holopapa ola o kekahi poʻe'ē he hoomalolo mea like i ka lā hoʻokahi.

Hana ma-ke ano

He aha hopena maikaʻi naoh ke kumu o ka lāʻau "Carboplatin"? Reviews e pili ana i keia mea paahana koi i ka mea hiki ke hoonaukiuki i ke kūpono 'ana o ke kēia adverse ole:

• Gastrointestinal nā loko: loko o 11-12 hola ma hope o hoʻohana ana i ka lāʻau, i ka hoʻomanawanui i ka mahina nausea a me ka luaʻi. Hoemiia pilikia o emetic reactions ka hoʻohana 'ana i ka mua? Eaia antiemetics, e like me intermittent mea, o ka medicament no 5 mau lā, a me ke ana intravenous infusion no ka lā. Kekahi, i kekahi nā mea maʻi i adverse reactions e like me diarrhea, abdominalʻeha, li nui o ka waha a me ka constipation.
• hematopoietic'ōnaehana: ka hoʻohana 'ana i nā māhele kiʻekiʻe o "carboplatin" ke uhi i ka hana o ka iwi lolo hematopoiesis. Nō hoʻi, he nui ka helu o nā mea maʻi akaka symptoms o anaemia, i ka nui o ka i hilinaʻi nui ma luna o ka laʻau heluna o ka lāʻau i hoʻohana. Pinepine pilikia a me ka lapaʻau complications e like me infectious maʻi, kuni, kahe ana ke koko a me ka hawewe septic.
• NAʻike ākea a Central ko mākou hopohopo'ōnaehana: aia no he likelihood kiʻekiʻe o ka uluʻike ākea neuropathies, e like me ka ka ho'ēmiʻana o ka hohonu tendon reflexes, o ka oi aku i ka poʻe ma luna o 65 makahiki. Eia hou, e hiki no na hoailona o CNS kāna hana hana. Hooloihi ae i lapaʻau me ka lapaʻauʻia hiki i huina neurotoxicity.
• Nā loko o ka hihio: ma ka hoʻohana o na dala ia mea paha i ka? Aiaiiuie mea hōʻemi a piha lilo o ka hihiʻo, a me ka poho o ka mea hiki, e ike i ka malamalama, a hoomaopopo waihoʻoluʻu. Maka hoihoi hou ia ana a me ka hana hou ana ia lŘlŘ i loko o kekahi mau pule ma hope o discontinuation o ka lāʻau. I kanaka me kaʻole hakuʻala kuleana pili i, ka mea, ua malamaia lakou me kiʻekiʻe nā māhele o ka lāʻau, malama cortical makapo.
• lohe nā loko: i ka hoike ana o "Carboplatin" i loko o kekahi nā mea maʻi he mea ototoxicity, i hoike mai ai ia ia iho i loko o ka palapala o ka lohe poho a me ka tinnitus.
• Allergies: wela, lapuwale ia erythematous, pruritus, anaphylactic naoh, urticaria, hypotension a me ka bronchospasm. Mau waiwai i hana i loko o kekahi mau minuke ma hope o ka lāʻau 'hooponopono. Nō hoʻi, ma ka pohihihi keia hoopii, hoʻomanawanui iki mai i ka mahina exfoliative dermatitis.
• ʻaʻa puʻuwai'ōnaehana: i ka hoike ana o "Carboplatin" kekahi hoʻomanawanui iki mai ka mahina i ka pokole a me ka mehana mahuahua i loko o ke koko a me ka lāʻau urea nā hoʻohui like. Ma keia hihia, huʻi poino i ka puʻupaʻa ka loa pohihihi keia. Ka pilikia o ka nephrotoxicity ma luna o ke kāʻei kua o ka pono o keia Agena maoli me ka mahele lāʻau, a pēlā hoʻi me kanaka muaʻia me ka cisplatin.
• Electrolyte koena: hypocalcemia, hypokalemia, hypomagnesemia, a me ka hyponatremia.
• Ake: i? Aiaiiuie mahuahua ma ka bilirubin nā hoʻohui like, KANAWAI a'ākilikai phosphatase i loko o ke koko hiki ke malama. People poe i ua malamaia lakou nei, me ka kiʻekiʻe nā māhele o ka lāʻau i ka autologous iwi lolo transplantation, nānāʻana aku i paewaewa ma ka akepaʻa.
• Other reactions: hemolytic-uremic maʻi pale, luhi, alopecia, congestive naau e hemahema, maʻi palū-e like symptoms, myalgia / arthralgia, allergic reactions, cerebrovascular kāna hana.

kiko'ī

He aha nā mea maʻi e ike mua ka hoʻohana 'ana i ka lāʻau "Carboplatin"? Na Ke Kumu, pākuʻi hoʻopaʻapaʻa ana i ka infusion o keia k ma lalo o ka ikaika nā limahana o ka 'inikua limahana wale hiki ke lawe mai, i specializes ma ka iapaau ana o cytotoxic konohiki. Ma keia koho kanaka hoʻoponopono hikiʻawahia loa, o ka oi aku ka wā kiʻekiʻe nā māhele o ka lāʻau.

Ma ka papa o ka Inc me keia Agena, a ma luna o ka mea e hiki mai ana na malama ekolu, nā mea maʻi e hoʻohana ike loea contraceptives.

No ka mea e hoomakaukau ai, a mahope hooponopono o ka lāʻau pāʻoihana pono e hoʻohana 'inikua lako i e ole no Aluminum. O ke kumu ho i ka mea i ka wā e hana ia me ka lāʻau precipitate ua hana a ua hoailono aku la ka ho'ēmiʻana i ka lāʻau hopenaʻoi loa.

Ma lapaʻau, "Carboplatin" koi 'ia papa'āweʻaweʻa kemika neurological examinations, a me na kanaka kūpuna, a muaʻia me ka cisplatin.

Hoʻohana hou o keia ka lapaʻauʻia i alakai i ke kūpono 'ana o ototoxic loa, a no ia mea, e halihaliia oia iwaho o ka mālama'-iapaau ana audiometric ho'āʻo ma.

Ma lalo o ka hooponopono ana o ka clinically nui aʻe 'ana o ka hālāwai hoʻolohe i pono i ka mahele lāʻau hoʻoponopono "Carboplatin" a me kona piha abolition.

Inā ka huina hoonui komo i kaʻili a me ka maka, holoiʻia ia koke me ka nui o ka wai. Inā ale, i ka mea e pono ai ka hoʻoponopono 'ana i ke kōkua palapala hōʻoia no.

Similar ai '

He aha lāʻau analogues hiki ke auou caiaiai "Carboplatin"? Na Ke Kumu no ka hoʻohana 'aʻole e apo ia i loko o kēia mau mea i ike. Ma hope mai ia oe, e i e huli i ka hoao ana i ka Kauka. E like me ka rula, poe akamai i waiho aku i ka hoʻohana i kēia mau analogues "Carboplatin" "Tsitoplatin", "Teksalok", "Displanor", "Oksiplat", "Oxaliplatin", "Platinol", "Cisplatin", "Eloxatin", "Platikad", "Plaksat "" Oksitan "," Oksatera "," Ekzorum ".

Reviews o anticancer ai '

no ke aha la oe e pono ai e like me ka lāʻau 'like "Carboplatin" ( "Carboplatin Teva") Ano, e ike. Na Ke Kumu no ka hoʻohana ana i keia k ua, ua ho'ākāka 'ia ma kekahi ma luna.

Loiloi 'ana o nā mea maʻi i ka kaʻawahia a me ka hopenaʻoi loa o ka lāʻau "carboplatin" Ua controversial. Kekahi kanaka olelo e pili ana i ka maikaʻi i nā hualoaʻa ma ka iapaau ana o kekahi mau maʻi 'aʻai, a me ka loa pinepine hōʻike i kaʻawahia ole o ka ai' i kela kanaka nā loko a me nā 'oihana, e like me nā ioʻike manaʻo. Mau loea, e olelo aku i ka mea, ua pili i ka kanaka ahonui ioeeiiaiey o kaʻeleu lāʻau waiwai a me kona mau ano. Ma kekahi hihia e noi mai ana i ka maʻi 'aʻai chemotherapy. Inā ka lāʻau "Carboplatin" ka hoʻomanawanui mea i pono ai no kekahi kumu a me kekahi, a laila ka mea, ua auou caiaiai ia analogs. Kēia hope antitumor lāʻau kōkua i loko o 90% o ka hihia.