Pōkole peptides a polypeptides me hapa o ka haʻuki kino. He aha e koho?

Peptides mea he kaulana mea i hoʻohana 'ia i loko o nenoai i loko o ka makaukau o ka haʻuki kino o ka' âlapa ma aeoaeuneiai a me ka 'oihana sport [3]. All peptides - haʻuki kino eiiiiiaiou - hiki ke maheleia i loko o 2 pūʻulu: pōkole (liʻiliʻi) peptides a me polypeptides ( "nui"). Nā peptides i haku o ka poe noonoo ole eiiiiiaiou -'amino nāʻakika. Inā kekahiʻakika'amino i loaʻa i ka uuku o ka'amino nāʻakika, no ka laʻana 3 a me 4, - ia mea he pōkoleʻakika'amino. Inā kaʻakika'amino mea 20-30'amino nāʻakika, a oi - ia mea he polypeptide. Polypeptides - keia mea kokoke i ka like me ia o nā polokina - ki nā lātoma i loko o mākou kino. No ke aha la ka mea nui no laila, i ka mahele i loko o pōkole peptides a me polypeptides? Mai ka lōʻihi o kaʻakika'amino hilinaʻi nui no kona kuleana pili i, ka hoʻokōʻana a me ka maluhia, i ka wa ia i loko o haʻuki kino.

Currently mahalo me ka sport kino eiiiiiaiou i polypeptides i ka paipai momona wela ikaika, hoonui Muscle nuipa a, mahuahua e hoʻonele, ka hoʻoikaika 'ana nohona ola. Naʻe, ka mea, i nui drawbacks. Polypeptides, o ka oi akuʻakika'amino hormones, i e incompatible i kekahi i kekahi, ma loko o nā hormones maoli i loko o ke kino. Eia hou, i ka "nui" peptides i haole i ke kino, a hiki i allergic reactions. High physical hana i mau ho'āʻo ma ka 'âlapa, pinepine he hoʻonui i ka emi ma e hoʻonele, a hoi maoli i kaʻaoʻao allergic reactions mai ka hoʻohana' ana i nā polypeptides. No ka mea, na polypeptides i pinepine kaʻawale mai ka holoholona meaola [2, 3, 9], i wāwahiʻia ai ka hoʻomaʻemaʻe 'ike loea i loko o ia palapala impurities i e ike - haole nā polokina, DNA koena ai, nā mea hoʻomaʻi, prions, a i loaa immunogenicity (hana e induce allergy) a hiki alakai i ka ulu ana maʻi.

Ua mea hiki e hana pela, e malama pono keia mau mea waiwai o bioregulatory polypeptides, a ma ka mea ia manawa, e wehe i ko lakou mau hewa? Ae, e ka mea, ua lilo ia i mea e hiki ai. E like me ka hopena o nā makahiki o ka noiʻi, ka mea i loaʻa i kēlā me kēia polypeptide mea heʻeleu-oaio? A - i ka hapa uuku wale no o ka mea, i mea kuleana no ka hana o kaʻakika'amino. Ma muli o ka Ikepili o ka haku mele 'ana o polypeptides e like me ka kūikawā' enehana maikaʻi Pharma GmbH pōkole peptides i ua hana, oia hoi o ka 2, 3 a me 4'aminoʻakika residues [5, 6, 7]. Ua pōkole peptides i pono e kaʻawale mai ka holoholona nā'aʻaʻa, a me ka mea hiki ke synthesized chemically. He lua pele no ka mea, kemikala peptides mai i pihaʻi me nā mea hoʻohui i i allergies. Penei IPH pōkole peptides ma luna o ka 'ole loa'ālike i maoliʻeleu (iaea ooieoeiiaeuiiai) polypeptide nā lātoma-oaio? A, a i ole ike ma ke kino, e like me na waiwai. He nui ka e hoailona oukou i ka pōkole peptides IPH, iʻano nui "hana" o ka polypeptide lātoma hoʻohana i ka haʻuki kino ma pae haʻahaʻa ma mua o ka "nui peptides."

ʻO kekahi mea nui ia Morohiha o IPH pōkole peptides o ko lakou waiwai, ua maikaʻi ke kemu ma ke kino hoʻohālikelike i ka polypeptides. Pehea ke ano o keia hana? Nā polokina a me polypeptides komo i ke kino a me ka ai, e komo i ka'ōpū a me ka naʻau liʻiliʻi. Aia ka mea, e me ke kōkua o kūikawā nā'ūhū (peptidases) "oki" i loko o liʻiliʻi koena ai - pōkole peptides oia hoi o ka 2 a 3'aminoʻakika residues. A laila, pōkole peptides komo i ke koko, a kaʻi aku i na nāʻiʻo a me nā nā loko a me nā'aʻaʻa, a i ka hoʻokonukonu hopena. Ka hapa nui o na polypeptides, a loaa ia makou e like me kekahi hapa o nā haʻuki kino e e "ʻoki" peptidase a e ole i ka mea i makemake kanawai, a me ke kanawai, e e nawaliwali. Ma keia pōkole IPH peptides i kekahi hapa o nā haʻuki kino e koke mai ka'ōpū a me ka naʻau liʻiliʻi komo i ke koko a me nā'aʻaʻa, me ka wawahi. Currently maikaʻi Pharma GmbH 'ia a synthesized i ka moʻo o ka pōkole peptides, i kapaia o IPH, no ka mea lāʻau lapaʻau, ka ai, mea hoʻonani a me ka haʻuki hana, a hoʻoulu i ka'ōnaehana paleʻea, ko mākou hopohopo a me ka endocrine nenoai, i antioxidant waiwai, haʻalele pūnao, a malama no ka Kāohiʻana o ka maʻi' aʻai, a mahuahua longevity [5, 6, 7, 8]. It E e kaulana i polypeptides ka mea, e ike mau i ka kiko'īʻano papa hana o liluwelo haʻawina, akā, no ka pōkole peptides IPH ia haʻawina paʻa nui maʻalahi a ua hiki mai ai i nā'ōewe kumumea i ka holoʻokoʻaʻakika'amino hanaʻano papa hana [1, 5, 6, 7, 8, 10 ]. Ua apono 'oe, e hoomakaukau aku no ka hopenaʻoi loa a me ka maluhia o ka pōkole IPH peptides hua mai la ia e maikaʻi Pharma GmbH (Germany).

Penei, ka pōkole peptides IPH, loaa a pau o ka liluwelo loa o polypeptides, palekana, ole-immunogenic, i 'epekema-ma muliʻano papa hana o ka hana a me ka mea o ka maikaʻi pāʻoihana like me ka haʻuki kino eiiiiiaiou [4] a me ka maʻi lele o? Acaeoey o kēia pharmacology a me hakakino lapaau.

Sources hookoiaʻi ka hopenaʻoi loa a me ka maluhia o ka pōkole peptides

1. Ashapkin VV, Linkov NS, Havinson VH, Vanyushin BF Epigenetic maomeka peptidergic rula hooponopono o ka'ōewe olelo i kūnewa kanaka keena // Biochemistry. - 2015. - V. 80, hoopuka aku. 3. - P. 374-388.
2. Zilov I Kumuʻiʻo eiiiiiaiou ma ka hana kūikawāʻai no sportsmen // kino. - 2014. - T.83, №53. - C. 133.
3. Mezenova NY, vertuhaya VV, Volkov VV, Baydalinova ls Mezenova oj Hoʻoholo 'ana iʻanoʻenehana kiko'î a me ka pauka, o ka hana peptides mai iʻa unahi me hapa o ka Bio-huahana i nā haʻuki kino // hana o nā kulanui. Haʻapili kemika a me Biotechnology. - 2016. - №2 (17). - S. 104-114.
4. Havinson VH, Trofimova SV, Trofimov door, Kachan EY, Wiener Usmanov IA Terekhina RN, Kryuchek es, EA Pyrozhkov Nā Papahana nānā 'ana i hoʻoulu i ka nui o ko lakou hoomakaukau ana kiʻekiʻe papa gymnasts hana o kūikawā physical aʻo a me kaʻakika'amino bioregulators. // Nā Kūlana. - St. Petersburg: St. Petersburg Bio-hooponopono a me Gerontology Institute.. - 2013. - 44 p.
5. Khavinson V.Kh., Polyakova VO, Linkova NS, Dudkov door, Kvetnoy IM Peptides hooponopono Cortical Thymocytes Differentiation, ka hoʻonuiʻana, a me Apoptosis // Pai o'amino nāʻakika. 2011. ArticleID 517137. P. 1-5.
6. Khavinson V.Kh., Tendler SM, Rfsyanenko NA, Tarnovskaya Si, Linkova NS, Ashapkin VV, Yakutseni PP, Vanyushin BF Tetrapeptide KEDW hana me ka DNA a me Regulates'ōewe 'aoʻao o // American Pai o Biomedical Sciences. - 2015. - Vol. 7, N3. - P. 156-169. Khavinson V.Kh., Tendler SM, Vanyushin BF, Kasyanenko NA, Kvetnoy IM, Linkovan.S., Ashapkin VV, Polyakova VO, Basharina makou, Bernaotte A.ʻakika'amino rula hooponopono o ka'ōeweʻana a me ka kumuʻiʻo hoʻololi kemikala ma Bronchial Epithelium // akemāmā. - 2014. - Vol. 192. - P. 781-791.
7. Medvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, Dergunova LV kaʻakika'amino semax e loli ai i ka hōʻike o nā'ōewe e pili ana i ka'ōnaehana paleʻea, a vascular nenoai ma ka iole lolo mea nui ischemia: genome-akea transcriptional Ka Ikepili // BMC Genomics . - 2014. - Vol. 15. - P. 228.
8. Stadnik J., Kęska P.ʻiʻo, a me kaʻawaʻawa ai nā huahana like me ka kumu o bioactive peptides // ActaSci Pol .Technol. Aliment. - 2015. - Vol. 14, N 3. - P. 181-190.
9. Sweetwyne HI, Pippin JW, Eng DG, Hudkins KL, Chiao Ya, Campbell HI, Marcinek DJ, Alpers ce, Szeto HH, Rabinovitch PS, Shankland SJ ka mitochondrial-hoʻomākaʻakika'amino, SS-31, iaono? Ienoai glomerular kuhikuhipuʻuone i kaʻiole o ka holomua makahiki // hakuʻala Int. 2017. S0085-2538 (16) 30652-4.