Ursodeoxycholicʻakika: aʻo no ka hoʻohana 'ana, analogs, hōʻike manaʻo

Nei, no ka iapaau ana o kekahi mau akepaʻa lesions ua increasingly hoʻohana ursodeoxycholicʻakika. Na Ke Kumu no ka hoʻohana ana i ka Nine Inch hui nui kona laulā ma na maʻi nui. He aha mea keia mea? He aha ka ursodeoxycholicʻakika? Ma aha huahana ia mea i hiki mai?

hōʻikeʻano

Ursodeoxycholicʻakika, i ka hana o ka i ka nānā 'ana ma luna o kona kumu a me ka waiwai, mea he keʻokeʻo-melemele mea pōaka ka pauka. Ua loaʻa i kaʻaiʻana awaawa. Kēia waiwai i loko o ka maʻamau functioning kanaka meaola ua hua mai la i ka poe liilii, mea. Kona mau 'umekaumaha mea e pili ana 5% ma ke kaupaonaʻana o ka heluna bile nāʻakika. He hydrophilic, a i ole cytotoxicity. Kēia Nine Inch i huiia Ua wailana ma ka waiʻona, a mauʻaʻei aceticʻakika, iki wailana ma ka chloroform a kokoke insoluble i loko o ka wai. Ursodeoxycholicʻakika ua ole iloko o loko o nā huahana. Ua i loaʻa i loko o ke au bladder o ka mea eleele bea.

Ursodeoxycholicʻakika (UDCA) mea he epimer o chenodeoxycholicʻakika. Initially ka mea, i ia no ka iapaau ana o ka reflux gastritis a me splitting gallstones. Over manawa, ka mea, hoomaka ae la ia e hoʻohana ', a ma na mea he nui' ē aʻe ka maʻi. UDKH noʻonoʻo i ka loa paʻa o ka bile nāʻakika.

Kanawai o ursodeoxycholicʻakika

I ka lā, i ka hoʻohana 'UDKH mea he maʻamau Inc no kela cholestatic akepaa maʻi me ka autoimmune ke keʻena. Keʻano papa hana o ka hana ana o keia Agena mea e stabilize na keena o ke kino. Kona nā lātoma hiki e hoohui i loko o ka membranes o ke akepaʻa keena - hepatocytes. No ka mea, o keia mea hiki ke hana ia aku hoʻopale i corrosive aʻe ka mea. Kēia hepatoprotective Agena i ka choleretic hopena. UDKH emi naʻokoko hoʻololi kemikala i loko o ke ake, a ua ālai 'kona omo i loko o ka naʻau liʻiliʻi. Kēia lāʻau 'emi, a ke hoala mai lithogenicity bileʻakika maʻiʻo ma loko. Ua hoʻokāʻoi aʻe ana i ka ha awina o lipase, pancreatic a me gastric secretion. Ursodeoxycholicʻakika i ka hypoglycemic ia, a stimulates ke kahua a me ka hookaawale ana o ka bile, e ho'ēmi i kā naʻokoko.

Kēia lāʻau makemake ia ka helehelena a piha cleavage o ka naʻokoko pohaku. I ka mea kumu ka mea, ua hoʻohana 'ia hou pinepine ana. Ai pili aku me ka naʻokoko, ka mea maoli i ka solubility o kona nā pōaka, i hana deleteriously ma gallstones. UDKH i immunomodulating hana i mea e hoomahuahua i ka lymphocyte ha awina, ho'ēmi i kā ka hōʻike o okoa antigens ma na membranes o hepatocytes. Ka mea, e loli ai i ka helu o T-lymphocytes, ho'ēmi i kā ka helu o eosinophils.

UDKH ho'ēmi i kā ka lehulehu o ka naʻokoko ma ka bile ma kona hoopuehu a me ka hoʻololi o ka waiwai i loko o ke kinowai aniani pae. Ka mea, e loli ai ka enterohepatic holo o ka bile paʻakai. E like me ka hopena o keia ua hoʻemi reabsorption i loko o ka gut o endogenous hydrophobic a me kaʻawahia i huiʻia. Kēia lāʻau i ka pololei a me ka hepatoprotective choleretic hopena. Ursodeoxycholicʻakika, mai i hōʻike manaʻo o ka hoʻomalu ma hepatology ÷ ike kona laulā, Ua hiki ke hoemi akepaʻa fibrosis i loko o kona momoma degeneration.

palapala noi

Ursodeoxycholicʻakika, a noi ua hana ma lalo o ka hooponopono ana o ka mea e hele ana i kauka ua häʻawi mai ma ia pathological ana:

• imua o ka naʻokoko pohaku IIeEeAIEUIeXAIIUE i loko o ka gallbladder a like leki uea;

• hikiʻole e hana endoscopically paha surgically;

• maʻi, atypical, a me ka huʻi autoimmune hepatitis ;

• imua o ka naʻokoko pohaku ma hope me mechanical a me ka extracorporeal lithotripsy;

•ʻawahia (lāʻau, ka waiʻona), ake pōʻino;

• sclerosing cholangitis;

• iniiaiie biliary cirrhosis, a me i na hoailona o ka decompensation;

• atresia, biliary'āpana;

• cystic fibrosis;

• maʻiʻeleu hepatitis;

• cholestasis ma parenteral no kou kino;

• biliary dyskinesia;

• biliary dyspeptic maʻi pale me ka biliary dyskinesia a me ka holetsistopatii;

• maʻi opistorhoze;

• congenital biliary atresia;

• biliary reflux esophagitis a me ka reflux gastritis.

Ursodeoxycholicʻakika (UDKH) i hoʻohana no ka Kāohiʻana o ke akepaʻa poino e poloʻai pule ma aaieieno? O cytostatics a me hormonal contraceptives. Ua Ua hoakaka ia no ka 'ē aʻe mai ke kumu ma ka stagnation o ka bile. UDKH hāʻawi no ka adjuvant Inc ma ke akepaʻa transplantation 'ole' ē aʻe hui,.

Contraindications

Ursodeoxycholicʻakika, i hōʻike manaʻo ka hapanui loa 'oluʻolu, he contraindications kaumaha. Mau nā:

• hoʻoʻino maʻi o ka make bladder, liʻiliʻi a me ka bile ducts i loko o ka huʻi pae;

• rentgenopolozhitelnye gallstones me kiʻekiʻe kalipuna maʻiʻo;

• iaʻi o ka biliary'āpana;

• hypersensitivity;

• cirrhosis i decompensation;

• Crohn ka maʻi;

• haʻi paewaewa ma ka functioning o na pancreas, ake a me ka hakuʻala.

hoʻokau 'o ka i

Ursodeoxycholicʻakika, olelo ao no ka hana i maopopo Hōʻike i ka wa e kaawale aku o ka ikaika hoʻokau 'i loko o kona palapala noi, ua i ia mau keiki, i ka 3 makahiki ma ka mea hōʻikeʻikeʻuʻuku palapala. No kā lākou hoʻohana ana i ka slurry ec i kēia lāʻau waiwai. Hiki i keia manawa, mākaukau i ole, ua mālama 'ia kūpono haʻawina nona i' ike i ka hopena o keia waiwai cholelitolitic ke kaumaha ma muli o ka makahiki o ke keiki. I ka Ia manawa, haʻawina mālama 'ia i loko o ke alo o ke keiki me ka biliary atresia a me kekahi ake maʻi i ole hōʻike kekahi pediatric pilikia.

Hoomakaukau i loaʻa ka ursodeoxycholicʻakika, haawi mai i ka hapai wahine wale i ka wa a ka Manao iho la ia hopena o ka Inc me keia Agena mea oi aku ma mua o ka Loaʻaʻia kamepiula a hiki i ka unborn keiki. Mākou e ole hoʻopoina i ka piha scientific study o ka Nine Inch palekana no keia waeʻano o nā mea maʻi uaʻaʻole pau keia la. No ka ua i ikeia ina paha UDKH komo i loko o ka umauma o ka waiu, mālama nui ua pono ai i loko o ke kauoha o ka lāʻau i ka poe wahine.

ʻaoʻao waiwai

Ursodeoxycholicʻakika, olelo ao no ka hoʻohana i ka 'ole wale i ka hoʻokau' i loko o kona palapala noi, akā, no hoi i hikiʻaoʻao waiwai, e alakai i ka pathologicalʻike manaʻo e like me:

• constipation, diarrhea;

• nausea;

• mahuahua transaminases;

•ʻeha ma ka akau luna quadrant a me epigastric māhele'āina;

• allergic ili reactions (ka ohane, wikiwiki);

• calcining na pohaku.

Lapaʻau o iniiaiie biliary cirrhosis keia hoʻomākaukau i kekahi manawa ke kumu i ka hoʻomanawanui i decompensation ao pau, nalowaleʻana aku ma hope o withdrawal loaa ana keia k.

precautionary ana

E ana litholysis naʻokoko pohaku ka hoʻohana UDKH pono e lawe i loko, no ka mea ma lalo nei:

• lākou nui mea i oi ma mua o 2 knm;

• ka mea, e mai i malu ma ka radiograph;

• gallbladder ua functioning maʻamau;

• ducts mālama patency;

• he Oe piha i na pohaku emi ma mua o ka hapalua;

• ka maa bile leki uea 'aʻole e loaʻa nā pōhaku.

He aha nā kapu ma ke komo mea ursodeoxycholicʻakika? Na Ke Kumu i keia 'inikua hoʻomākaukau i ka' ana i ka lōʻihi-makahiki lapaʻau, i mea oi aku 1 ka malama, pono e mau (1 kela 30 lā), e hoʻomaka ka mālamaʻana o hepatic transaminases, phosphatase, bilirubin, gamma-glutamyl transferase koko. E mālama nei ia kālailai mea pakahi aku la ia nui i loko o ka loiloi mua 3 mahina o ka Inc me UDKH. I ka laulā o ka iapaau ana ua hookupaa iho la ia ma ka X-Ray kela i nā malamaʻeono, a ultrasound bile. No ka mea Kāohiʻana o ka recurrence o ke kāʻili 'ana e hoʻomau i ka cholelithiasis lapaau, a ma hope o piha noho male' ana o nā pōhaku. Ua hiki ke lawe i na mahina.

Ma lapaʻau UDKH wahine o ka hanau keiki ana nā makahiki ua? Aeiiaiaoaony e hoʻohana ike loea ano o ka palekana i ka hāpai keiki. Ua hiki e 'ole-hormonal ai' ole contraceptives na dala uuku o ka estrogen.

Release palapala a me ka laʻau heluna

Ursodeoxycholicʻakika, ma i manual haawi i ka piha ano o kona? Eaia circuitry, ua ua hanaʻia i loko o ia mau laʻau heluna 'ano apau loa.

• Capsules a me na papa io o ka 150 a me 250 mg;

• wehe na keiki.

Laʻau heluna UDCA pololei i pākahi. Ua hilinaʻi nui ma luna o ka oolea o ke kanaka ana, a me kona kino ke kaumaha. Ma ka hapanui o na hihia, ka mea, ua hoakaka ia e 10-20 mg / kg no ka lā. Kēia mahele lāʻau ua ia i kekahi manawa, ma ke ahiahi. Ka lōʻihi like 'ole o ka Inc hilinaʻi nui ma luna o ka hoike. Kēia lāʻau ke kemu i loko o ka poe uuku naʻau liʻiliʻi, a ma hope o 3 hola o ka wai koko ua kaulana no kona kiekie loa lehulehu. A eia i? Eaia medicaments i loaʻa ka ursodeoxycholicʻakika,ʻo ia ka mea, i ka iniiaiie bileʻakika i loko o ke kanaka kino. Keia mea i na hoopai ana a hiki i keʻano o nā loli 'a me ka hopena hope o ia auoiaea like metabolites ma feces a me ka mimi.

Duration o Inc me ka nānā 'ana i ka hele kauka. Ua hiki e okoa ke kaumaha ma muli o ka 'ano o ka maʻi. Ma kekahi hanahana loa hoopii, ke hiki aku UDKH ai 'mau no ka makahiki.

AaOIeIOUIeXAOAaIN me nā ai '

Ma ka olelo? Eaia a me UDKH "Cyclosporine" unpredictable, piʻi pū ka omo o ka hope. I ka wai koko dramatically maoli i ka lehulehu o ka lāʻau lapaʻau hoomakaukau. Ma pohihihi keia hihia i ka loaa ana UDKH ka poʻe me ka makaukau "Ciprofloxacin" hope lehulehu emi.

Ursodeoxycholicʻakika (analogues)

Ursodeoxycholicʻakika (capsules, papa) ua hanaʻia ma lalo o kekahi mau inoa. Na konohiki OAOOUIEeE excipients komo i loko o lākou haku mele 'ana. Ke'ī mai, ke kuai hiki halawai mau ai 'me ka ursodeoxycholicʻakika.

• Capsules "Ursosan" i hoakaka ia no ka Inc eiei? Ake maʻi, cholelithiasis, me ka biliary reflux gastritis a me ka reflux esophagitis, iniiaiie cirrhosis, ai 'a me kaʻawahia ake poho, cholecystectomy, waiʻona maʻi, sclerosing cholangitis, Biliary atresia, nonalcoholic steatohepatitis. Ursodeoxycholicʻakika ( "Ursosan") ua hoʻohana 'ia no ka Kāohiʻana o ke akepaʻa lesions.

• maloko o na papa "Ukrliv" ka poe i lawe i ka hepatic hoʻopilikia, maʻi hepatitis, cholelithiasis.

• Capsules "Ursofalk" koho no kela maʻi o ka gallbladder a me akepaa, ai ukali ma cholestasis, he emi no kekahi akepaa hana, ke kiekie naʻokoko pae. Mau nā iniiaiie biliary cirrhosis a me ka sclerosing cholangitis, reflux gastritis a me ka reflux esophagitis, hepatitis o kekahi etiology, naʻokoko pohaku, cystic fibrosis, mau lesions o ke akepaʻa, bile stasis. Ua makaukau ua hoʻohana 'ia e like me ka prophylactic ku e ake ino, i ka wa e loaa ana potent ai'.

• maloko o na papa "Ursodeks" ka poe i lawe ma biliary cirrhosis ole decompensation symptoms a me reflux gastritis. Ka mea, i hoʻohana 'ia e hoike mai i ka poe liilii, naʻokoko pohaku ma ka maʻamau functioning o ka laau make bladder.

• Capsules "Ursodez" hoʻohana i ka uhai ia naʻokoko pohaku, i ka iapaau ana o ka reflux gastritis, no ka mea symptomatic Inc no iniiaiie cirrhosis o ke akepaʻa a me i na hoailona o ka decompensation.

• Capsules "Ursolizin" koho no ka mea hoʻoheheʻeʻia naʻokoko na pohaku, a me ka symptomatic hana o biliary cirrhosis, gallbladder cholesterosis a me ka reflux gastritis. Ka lāʻau 'Ua hoʻohana' ia i loko o ka luna 'Inc no nā mea maʻi me ka maʻi hepatitis a me ka cirrhosis.

• Capsules "Choludexan" hoʻohana i ka iapaau ana o uncomplicated cholelithiasis, maʻiʻeleu hepatitis, kanakaʻona mau a me kaʻawahia ake lesions, nonalcoholic steatohepatitis, iniiaiie biliary cirrhosis, iniiaiie sclerosing cholangitis, cystic fibrosis, biliary dyskinesia, reflux gastritis a me ka reflux esophagitis.

• Capsules "Urdoksa" mea i koi 'ia ma iniiaiie biliary cirrhosis, a me i na hoailona o ka decompensation, reflux gastritis. Ka lāʻau 'ua pono hoike mai i ka naʻokoko na pohaku uuku a me ka meakino, me ka maʻamau hana o ka laau make bladder ana ka malama ana.

• Capsules "kahaʻimo C", ia ma uncomplicated cholelithiasis, iniiaiie cirrhosis, huʻi a me ka maʻi hepatitis, sclerosing cholangitis, atresia intrahepatic'āpana, reflux gastritis a me ka reflux esophagitis, cholestasis, iloko o parenteral kino, biliary dyskinesia, akepaa maʻi, me ka cystic fibrosis, momona gepatoze, dyspeptic syndromes. Ke kanaka e hoomakaukau i ua hoʻohana no ka Kāohiʻana o ke akepaa poino ma o ka hoʻohana o hormonal contraceptives a me cytostatics, pohaku ho okumu ma obesity.

Ursodeoxycholicʻakika, analogs o keia mea i lawe wale i hoakaka ia ma kekahi kauka.