Insulina-e like ulu ololi: ka kūmau a me ka haiahū kūmau

Insulina-e like ulu ololi i kapa hōmona like i loko o Nine Inch 'ole i ka insulina. Ua regulates aeea differentiation keʻano o ka hanaʻana, i ko lakou ulu ana a me ka ulu ana. Ua Ua pū kākou ma ka monakō koko pūnao.

Mōʻaukala o ka Kaka

Back i loko o ka weuweu 50s o ka iwakalua kenekulia, ua? Aaei epekema i waena o ka ulu hōmona (Mahele), i ua i kapaia o ka ulu hōmona a me ke kino o ka keena, he mea kekahi intermediary. Kēia hopena kupu mai ka mea e ulu hōmona i ka hopena wale nō ma luna o ka meaola ola, akā, i ka wa a ka mea, ua lawelawe i loko o ka Muscle keena, a hiki ina ka mea, ua i loko o ka nutrient meakino, i malama ole ai.

Ma ka 1970s, ka mea i loaʻa somatomedins, i i oleloia ma na uao. Ka mea, i kapaʻia insulina-me ka ulu ana aʻe. Initially kaʻawaleʻekolu pūʻulu o ka waiwai: A somatomedin (IGF-3) a me B (IGF-2), C (IGF-1). Akā, ka mea i manao ia ma ka 1980s i ulu insulina-e like ololi-2, e like me 3 - kēia mea wale nō i kekahi mana artifact, akā, ma ka ike maopopo ia hakuʻole. Wale hoopaa i ke alo o ka IGF-1.

'ole

Insulina-e like ulu ololi 1 (IGF-1) he 70'amino nāʻakika i kuahene intramolecular linkages me ka lei-na alahaka. He Heʻakika'amino ka mea e hoopaa ai i ka wai koko nā polokina, ka ai-kapaia maoli ulu ololi. Ka mea, ae somatomedins noho hana nui ana. Ua lawe kekahi mau hora, oiai ma ka noa palapala la manawa mea i oi mamua o 30 minuke.

Ke hōmona Ua like ke proinsulin, no ka i loaa ia ia i kona inoa. A i loko o ka hoʻololi kemikala o somatomedin nunui kūlana pâʻani 'o ia ma ka insulina' ana. Ma hope o nā mea a pau, e ka poʻea pau i loaa i ke koi 'ia'amino nāʻakika ma ke akepaʻa, e hoʻomaka i keʻano papa hana o ka hanaia'na o ka FMI.

hoʻololi kemikala hōmona

I aku la o ulu ololi noʻonoʻo endocrine mediates ka hoʻolako 'hana o ka ulu hōmona. Ua Ua synthesized ma hepatocytes o ke akepaʻa ma muli o ka mea loaʻa stimulation. Ma aneane a pau nā'aʻaʻa i ka hana o ka ulu hōmona ua hoʻolako 'ia e IGF-1. ia i loaʻa, mai ke akepaʻa, i loko o ke koko, a me ka mai ma laila, ma ka 'uao' ana o ka lawe nā polokina i loko o nā'aʻaʻa a me nā loko. I aku la o hōmona stimulates ka ulu o ka iwi, connective'aʻaʻa a me nāʻiʻo. Nō hoʻi, insulina-e like ulu ololi synthesized kū kaʻawale ma na mea he nui nā'aʻaʻa. Inā pono, kēlā halepaahao hiki kū kaʻawale hoolako ia lakou iho me keia waiwai.

Secretion o IGF-1 ma ke akepaʻa, piʻi pū ma lalo o ka hana ana o estrogens, androgens, insulina. Akā, ka mea glucocorticoids ua hoemiia. Ua Ua manaoia e lilo i kekahi o na kumu i kēia mau waiwai lakou aloha i ka ulu a me ka hooulu ana o ka meaola a me kona uku o ka moe maturation.

waiwai

IGF ma Muscle aeee ka lawe ulu noho haumāna kahi hope a me ka insulina. Ua catalyzes ka hoʻololi kemikala o ke kumuʻiʻo , a 'aʻole hoʻi i ka kaʻina o ka make. Ua hoʻi i hoʻololi i ka pūnao, ka paipai 'ana i ka hōʻeleu i momona aa ana.

Insulina-e like ulu ololi-1 ua pili me ka pituitary gland a me ka hypothalamus. He loaa ia i loko o ke koko hilinaʻi nui ma ke koho ana o nā hormones. No ka laʻana, ma ka haʻahaʻa lehulehu maoli ka secretion o ka ulu hōmona. Hoi kekahi poe kanaka maoli he? Iecaianoaaiiuo o ka ulu hōmona-opa hōmona. Akā, ma kiʻekiʻe pae o ka IGF-1 secretion o mai la ua hoemiia hōmona.

Ma waena o somatostatin a me insulina-e like ulu ololi mea ua hookupaaia ka pololei pili. Me ka ulu ana o kekahi o ia mau mea, piʻi pū, a me ka lehulehu o ka lua.

Mākou E hoi e hoailona oukou i hana ia me ka lāʻau anabolic 'âlapa i ke kumukuai o ia. Ua Ua ua pinepine paʻi i ka hopena o nā haʻawina a i kapa ai i ka hopena maikaʻi hopena o ka hookolokolo ana e lawe ai 'i pihaʻi me insulina-e like ulu ololi (IGF). Kā lākou hana ke alakai i ka mimikō, pilikia makapō hoʻopilikia, kāna hana o ka naau Muscle, neuropathy, hormonal ka hoʻohuikau '. Eia hou, ua waiwai no kekahi o ka nui catalysts ulu o cancerous hikoko.

hiʻona IGF

Ua Ua ua mālama ia insulina-me ulu ololi 1 ua kuu iho la i ka elemakule, a me ka noho 'ana kamaliʻi, a me ia mea i ka lani kiekie loa i waena o adolescents. Akā, e like me ka noiʻi i loaʻa ia mua kanaka nona ka nui o keia hōmona mea kokoke i ke kee na palena o ka maʻamau no kā lākou mau makahiki pae ola hou. Eia hou kekahi, ka mea i emi prone i ka naau mai a me ka ipu koko. Kaawale, e pono ke kūʻai 'ana i kumumanaʻo i hoʻoulu i ka huina i hāpai keiki.

Koko lehulehu i ka lā mea e pili ana i ka ia. No laila, ka mea, ua hoʻohana 'ia e Loiloi i ka hana hoʻohaunaele i loko o ka ulu ana o ka ulu hōmona. Ma hope o nā mea a pau, i ka lehulehu o ka ulu ana hōmona i loko o ke koko loli aʻe ma ka lā, i ka i kā mākou kaʻilikai i hoakaka ia ma ka po. Nolaila, i ka pololei i ka huina mea problematic.

Hoemi i ka lehulehu o ka hōmona

IGF-1 Uaʻike wale nō i loko o ka makahiki 1978. No laila, ua, ua lilo loa i ka hailona o ka noiʻi, like me ka hopena o i i kau i ka helu o ke kānāwai. Penei, o ka nele o kona wā kamaliʻi o ke kumu no ka lohi o ka ulu a me ka physical? Acaeoey o ke keiki. Akā, i pilikia ina insulina-e like ulu ololi hoemi i loko o nā mākua. Ma hope o nā mea a pau, ka mea, ua hoʻomaopopo i ka underdevelopment o na nāʻiʻo, ua hoʻemi iwi nuʻa, loli i loko o ka 'ole o nā bipi kūpaluʻia.

Kena ae la e hoomaloka o IGF i e ka nui o nā maʻi. Iwaena o lakou, hakuʻala pilikia, ake. Pinepine i ke kumu o ka hoemi dala o IGF mea he maʻi e like me hypopituitarism. He He ano ma i ka lua hiki ana paha markedly ho'ēmi i kā? Iecaianoaaiiuo o pituitary hormones. Akā, i ho'ēmi i kā ka? Iecaianoaaiiie o somatomedin me ka nele o ka mana, a, oi wale, pololi.

Ke mahuahua ma ka IGF

I loko nō o ka hopena mea, i ke kumu no ka nele o ka IGF-1, ia mea,ʻaʻole e pono ke kuhi ana i ka hua ma ka helu o kona i inoino loa.

No laila, ina ka insulina-me ulu ololi 1 hōʻano hou, ka mea e alakai i ka acromegaly i loko o nā mākua a me ka gigantism i loko o nā keiki. ua hoikea mai oia, i hāʻawe maʻi like penei. Ka mea, hoʻomaka ka, pili iwi ulu. Kēia mea like me ka hopena o nā kumu,ʻaʻole wale nō, alahula ulu, akā, i mahuahua hope i abnormally nui nui like 'ole.

Acromegaly, a ia lŘlŘ i loko o nā mākua hele aku ai i? Anoe? O ka'ūhā iwi, na lima a me ka maka. I ae aku a me na nā loko. Kēia e alakai i ka make ma muli o ka cardiomyopathy - i ka maʻi i loko o i loli cardiac Muscle, hana kue i kona kuleana pili i.

Loa pinepine ke kumu i maoli he insulina-e like ulu ololi, he pituitaryʻeho. Mai ia oe ke loaa hoomaemae iho o me ke kōkua o ka lapaʻauʻia, chemotherapy, a me ka mea hiki ke wehe surgically. Ka Ikepili kōkua hoʻoholo pehea holomua Inc, a kaha paha o ka hana i lawe mai ka maiau. No ka laʻana, ina kaʻeho ua ole loa, ua wehe, ua mahuahua ka lehulehu o IGF.

e mālama nei i ka noiʻi

E diagnose loli i loko o ka lehulehu o ka insulina-me ulu ololi i loko o kēia keʻena hoʻokolohua-oaio? A hoʻohana IHLA hana. No laila, i kapaʻia immunohemilyuminestsentny Ka Ikepili. Ua Ua nānā ma ka'ōnaehana paleʻea pane o antigens. I ka anu u hoʻokaʻawale koi 'ia ka waiwai i pili ia beacons - phosphors, a e hiki ma lalo o ultraviolet malamalama. Lākou nui o ka luminescence ua anaia ka hoʻohana kūikawā lako a - he luminometer. E like me ka mea, i ka lehulehu o koho 'ona i loko o ka lāʻau lapaʻau.

Survey awina

E ho oholo IGF-1, insulina-e like ulu ololi, ia mea pono e lūlū mai ke koko ma ke kakahiaka obligatory hookeai. Ae e inu wale ka wai papu. I ka wā mawaena ma waena o ka hope palaoa, a me ka pa o ka mea no ka noiʻi e e oi aku mamua o ewalu hola. He mea nui i 30 minuke ma mua o ka haawi ana o ke Ka Ikepili ka hoʻomanawanui ua ma koena. No ka noiʻi lawe venous koko.

A, poe akamai i waiho aku, e haʻalele i ke Ka Ikepili i ka huʻi naehana maʻi (mea hoʻomaʻi ole mea koʻohune me Kinohi) i mea e hoʻopau wahahee hualoaʻa.

averages

I ka hoopiha ana mai ano i loko o ke keʻena hoʻokolohua ia mea nui e hoakaka i ka makahiki. Ma hope o nā mea a pau, ka mea hilinaʻi nui ma luna iho ona laila mea e e he ololi no insulina-me ka ulu ana. Ke kūmau ua hookupaaia no kēlā me kēia waeʻano pākahi. Ua mea no hoi e pono e kālele ana mai ma luna o averages akā, ma luna o nā 'ikepili o ka keʻena hoʻokolohua ma a au i lawe ho'āʻo ma. No ka laʻana, ma adolescents elemakule 14-16 makahiki hōmona pae paha e mai ka 220 a hiki i 996 ng / ml. A i loko o nā mākua, a ua oi aku mamua o 35 makahiki, ka mea e ole oi aku i ka waiwai o ka 284 ng / ml. I ka mua o ka hoomanawanui, ka mea haahaa i ka i kā mākou kiʻekiʻe o ka IGF e ia. Ma hope o 66 makahiki, me ka uku ua waiho ia ma ka laulā 75-212 ng / ml ma hope o 80 - 66-166 ng / ml.

Children IGF pae e no hoi hilinaʻi ma luna o kona mau makahiki. I keiki keiki, i mea ole, a hiki 7 lā, ka mea, e ia mai ka 10 a hiki i 26 ng / ml. Akā, ma hope o 16 mau lā, a mai ai i 1 makahiki, i hoonoho i ka uku ma 54-327 ng / ml.

ʻike, o ka maʻi

Ua hoʻoholo i ka insulina e like ulu ololi, e mea hiki ke diagnose i ka helu o ka maʻi. Mahuahua kona kiʻekiʻe o ka hoike ole wale no gigantism i loko o nā keiki a me nā acromegaly i loko o nā mākua. Kēia e He hōʻailona o ke akemāmā hikoko a me ka opu, maʻiʻaʻa puʻuwai ole hiki. Akā, he mea pono e kaulana no hoi ia ia mea hiki ke hoomahuahua, lalau dexamethasone, adrenostimulyatorov, alpha, Hoʻokolohua-blockers.

Hoemiia IGF pae i loko o nā keiki i ka hōʻike dwarfism. Ma nā mākua, i kaʻilikai ua pinepine hoemiia ka wā hypothyroidism, cirrhosis, anorexia nervosa a wale e hookeai ana au. Kekahi i kekahi no ka hiki kumu o ka maʻi hiamoe deprivation hea, a? Eaia helu o ka ai 'me ka kiʻekiʻe nā māhele o nā estrogens.