'O ka papa helu Prothrombin, ke kūlana a me ka waiwai

Prothrombin inideka, o ka uku o ka i mea like i 95-105%, - o kekahi o na nā hoailona characterizing koko clotting. 'O ka coagulation o ka toto he'ano ma'alahi ia, e pili ana i ka ho'opili'ana o nā protein kūikawā i kapa'ia he mau mea coagulation. Hiki ke ho'oikaika'ia o kēia ka'ina ma nā ala'elua - ma loko a me waho.

'O ia ka hua'ōlelo prothrombin e kuhikuhi ana i ka ho'onā'ana o ka hana'ana ma ke alanui'ao'ao. Loa'a i kēia mau mea: i ka wā e uhaki'ia ai ka pono o ke kino ('eha), kapa'ia he thromboplastin kikokiko, he pilikino kūikawā i loko o nā mea a pau o ke kino, ua huna. 'O ia ke kumu o ka hopena i ka hopena o ka ho'ohemo'ana i nā kumuhana (V, VII, a me X, II, I), e hana ana kekahi i kekahi. 'O ka hopena, he pai ke kāpili koko, a kāpae ke koko.

'O ka mea i'ōlelo'ia prothrombin index

Ho'okumu'ia nā mea pale i loko o ke ake. 'O kēia mau mea,'o II, V, X nā hua'ōlelo K. Me ka hapa o kēia hua'ahā ua ho'opi'i'ia ko lākou mana'o. No laila, aia nā hewa o nā hemostasis. 'O ka'ikepili prothrombin,'ike'ia ke'ano o ka prothrombin, hiki ke kauka:

1. Ho'ohālikelike e like me ka hana o II, V, a me VII a me X mau kumu ho'ohui
2. 'O ke kumu o kēia hō'ike e ho'okolokolo ai i ka hana o ke ake
3. Ma ke kīpī o ke kino me ka hua'a K
4. E pili ana i ke kūlana o ka pūnaewele ho'ohui kala
5. Hiki i kēia hō'ike ke nānā i ka pono o ka haukūna me nā mea hana'ehā.

Pehea i ho'oholo'ia ai ka hua'ōlelo prothrombin?

Ua ho'oholo'ia ka hua'ōlelo prothrombin i loko o ka capillary a i'ole ke koko'ona. Ma ka lua o ka hihia, ua lawe'ia ke koko ma ka'ōpū o ka'ōpū i loko o ka'ōmole a me ka mea e pili ana i kahi o 9: 1. Ma ke'ano he mea'oko'a, ho'ohana'ia ka hale sodium. I loko o ka ho'okolohua, ho'oka'ina'ia ke koko. Ho'ohana'ia ka plasma i ka ho'oholo'ana i ka manawa prothrombin (PT). 'O ka ma'amau o ka PV aia ma ka laulā o 12 a 20 mau kekona, ma muli o ka hana o ka thromboplastin, i ho'ohana'ia i ka manawa o ka ho'olele'ana i kēia kele.

'O ka'ike'ana i ka PV o ka mea ma'i, hiki iā'oe ke helu i ka PI,'o ia ho'i, ka index prothrombin, ka mea ma'amau i loko o nā papahana like'ole he'ano'ē a'e. He mea like i ka lākiō px ola kanaka i ka PV hoomanawanui, hoonuiia ka 100:

PI / PV zdor./Pv ma'i. X 100 (95-105% ka helu)

'O ke'ano ko'iko'i o PI

Ke ho'onui'ia ke kala, PV, a prothrombin paha, ka mea i ho'olālā'ia ma ka 12 a 20 kekona, a pi'i ka PI. Hiki i ka wā o ka hāpai'ana, me ka nui o ka trauma, ke komo aku ka nui o ka thromboplastin i loko o ke koko.

Eia ke'ano, pi'i ka PV, a ke emi nei ka PI me ka emi'ana o ka coagulation, e like me ke'ano o ka pilikia'ole o nā kumu ho'ohāpili, ma nā ma'i ate he nui, me ka lālā Kaila K (hiki ke hana me nā cholestesis, dysbacteriosis, me ka ma'i'ole o ka'ōpū). Pi emi me ka haahaa fibrinogen 'ole ka loiloi kino kīnā, me ka maʻi pale DIC, ma ke alo o ka waiwai i inhibit clotting.

He aha ke INR

Lapaʻau o ʻauhau'ēʻaʻe anticoagulants maoli ai ho'ēmi i kā prothrombin inideka. Hiki ke'oko'a kona kūlana ma'amau i kēlā me kēia hale ho'okolohua. No laila, i hiki ai ke ho'ohālikelike i nā hopena o nā kānalua i loa'a i loko o nā papahana ho'okolohua like'ole, ua ho'okomo'ia kahi ho'ā'o ho'ona'auao, e like me MNO. 'O kēia ka helu i helu'ia. Ua ho'oholo'ia ma ke kumu o ka lakene o ka manawa prothrombin o ka mea ma'i, ka nui o ka PV ma'amau a me ke ki'eki'e o ka helu kuhi mana'o thromboplastin (MIC).

MNO = (MF b-th / MF norm) i ke ki'eki'e o MIC

I loko o kahi kanaka olakino, INR ka mea i ka helu 0, 8-1.2.

Ho'ohana'ia kēia'ike e ho'oholo i ka pono o nā mea'oko'a. I ka mālama'ana i nā mea'ehā, ke ho'opau'ia ka coagulation, (e la'a, ma hope o ke kāpili na'au), e ho'onui'ia ka INR i 2-3. Me ka nui o nā ku'i'ana, ua emi iho ka INR. 'O ka lakio ma waena o PI a me INR he mea ia i ka emi'ana o ka PI, pi'i ka helu MNO.