Proton EII ni nā mea kūpale:ʻano papa hana o ka hana a me ka palapala noi i ka lapaau

Ma proton EII ni nā mea kūpale o ka pae o ka pharmacological Luna i emi ka uku o ka secretion o hydrochloricʻakika i loko o ka'ōpū. Me he pololei ia ma luna o ka secretory canaliculi, ka mea pono e alakai i ka makemake pākōlea ulcers hookoia, erosive gastritis, GERD. Ka hui ka loaʻa o ka ai iiiaanoaa o ai 'o like Nine Inch' ole, akā, ua okoa pharmacodynamic kiko'î, a laila kokoke i ka ia ai 'hana ana ma ka secretory keena, akā, i loko o kekahi nā hoʻohui like, a me kekahi, wikiwiki aʻela hana ai.

Proton EII ni nā mea kūpale: hakakino, ao ke ano ole hoomakaukau ana

Proton EII ni mea he luna 'kumuʻiʻo' ole lakou ke hoomaluia anal o ka hydrogen Ion ma ka gastric lumen. Ua he a mau chemically dissimilar hehee wale, ole kapaia subunits. Ka mua mea wale nō o ka kumuʻiʻo, a ua kūkuluʻia mai'amino nāʻakika. Ma kaʻili lahilahi aeea stuffer ia hoi ia ma ka kūikawā alanui, e holo ia 10 manawa, i hiki aku ai i ke kahua o ka 5-secretory Kanal puka lou. Maalo ae la oia ma ka lua o ka Ion hāʻule i loko o ka gastric lumen, a hoʻolako i ka acidification o ka meakino, a moe hydrogen inideka. Ma keia hihia ia mea i loko o kekahi o nā puka lou ka mea i kaʻeleu waena o ke kumuʻiʻo - he kaʻina o 800'amino nāʻakika, a catalyzes ka hālāwai hope o ATP, i ka papa kuhikuhiE ikehu aeea kūpapakū.

Other subunit mea he kumuʻiʻo eiiieaena i ua haku o ka polypeptide kaʻina, niioaaonoaaiii i kekahi kauoha 'ole a me ka glycoprotein kaulahao. Ke poi pu hapa o ka lātoma mea ma waho o ka cytoplasm, a me kekahi hapa o ka glycoprotein mea paha ekstratsitoplazmaticheskim mea loaʻa eiiieaena i kaʻohiʻana i i ka peahi o ka ho'ā hope o ka'ūhū H + \ K + -ATPase. Ma keia hihia i ke kumuʻiʻo hapa o ka lātoma nā keʻa i kaʻili lahilahi, hoʻokahi houʻana, A laila'ōlelo akula kona mea like me ka ai pili aku hehee ai ma waena o ka pahale mawaho, a me ka mua mea loaʻa subunit kuleana no ka mālama nei i ka catalytic naoh o ka hoʻololi kemikala o protons.

Alaila, o ka 'ole o ka proton EII ni secretory tubules parietal aeee ke hoʻopau pehea alodio ano hiki ke uhi i ka secretion o ka H + i loko o ke kino lua. Ka loa hoaponoiaʻano - ka inhibition o ka'ūhū kuleana no ka hoʻololi kemikala mea e proton EII ni nā mea kūpale.

Hoʻohana 'ana o nā mea kūpale i lapaʻau hoʻomaʻamaʻa

I ka lapaau, e hoʻomano hoʻohana proton EII ni nā mea kūpale, o ka oi aku ma ka gastroenterology, a ua pili i kā lākou waiwai, e emi i kaʻakika o gastric secretion, a pela emi ai ka nui o ka meaʻino wale i hookoia ma luna o ka opu pa, a mea oi loa nui ka wā ka mea, ua wela ai. Ma keia hihia i ka pākōlea hopena mea kuokoa o ka etiology o ka hoʻoʻino kaʻina hana, e like me ka mea ua wehe 'ia e keʻano pākīkē keiki a ma luna o ka pono o ke kino i ke kaiapuni. No hoi ka pae ana o pathologies i iapaau ana no ka hoʻokō 'ana o ka proton EII ni nā mea kūpale i ua hoʻonuiʻia gastric ulcer a me ka duodenal ulcer, erosive a me ka' ole-erosive GERD 'ano apau loa.

Mawaena o ka loa e like me ka lapaʻauʻia nā proton EII ni nā mea kūpale me ka kēia mau nōhie inoa omeprazole, rabeprazole, pantoprazole, lansoprazole, esomeprazole, a me na mea e ae. Iwaena o lakou i kuai inoa e kū mai, e like me "Omez". Laau lapaau i loaʻa i ka mea hōʻikeʻikeʻuʻuku palapala. Ka mea, ua lawe hōʻike waha 'i loko o ka hoakaka ia laʻau heluna o ka hoʻomalu, i loli aʻe ke kaumaha ma muli o ka mauʻano o ka maʻi. Oiai hele pakiko-hooponopono, e like me ka mea, he pūʻulu o nā mea maʻi i ohumu o naciiiuo exacerbation o ka maʻi gastric a duodenal ulcers. Ma nā hihia, ke hiki aku ua ua kūkākūkāʻia me ke kauka i ka manawa o ke komo.