Pemphigus vulgaris: mea, lalau mai, symptoms, lapaʻau, ka lapaʻauʻia. autoimmune maʻi

Pehea e holo ai ia i ka maʻi, e like me pemphigus? Lapaau a me symptoms o keia maʻi e kūkā mai ma lalo nei. Oe e kekahi aʻo e pili ana i na kumu o keia maʻi kaʻina a pehea kānaʻike.

kumu 'ike

Pemphigus, Hawaii photo i ua hōʻike i loko o kēia 'atikala, - i ka pae o ka pohihihi keia akā loa ke koʻikoʻi, debilitating a me ka palena papaha ona vesiculobullous autoimmune maʻi i aloha ia i kaʻili a me ka mucous membranes.

Poe akamai i kuhikuhi i ke kēia mauʻano o ka maʻi.

• pemphigus vulgaris;
• vegetans ano;
• ka lau;
• seborrhoeic (e i inoa e like me Sinera,-ke kahupuaa maʻi pale, a erythematous).

General ano o ka maʻi

Pemphigus vulgaris pahu i ka waeʻano o na maʻi o ka ili a me ka subcutaneous'aʻaʻa, a kahe ana i loko o ka maʻi palapala, me ka pinepine relapses.

Kēia maʻi He hōmona e kaukaʻi. Ua Ua wehewehe aku e holumua ai papa, e like me ke kahua o intraepidermal blisters.

Loa pinepine, pemphigus vulgaris e loli ai kanaka elemakule makahiki 50 a oi.

No ke aha la e keia maʻi ia lŘlŘ? Ke kumu no ka hooulu ana o keia maʻi, eia wale hypotheses.

Pemphigus: ka loa paha kumu

Ma mua o lapaau, i ka maʻi i loko o nīnau ka mea nui e loaʻa mai ke kumu ia mea ala ae la he autoimmune maʻi mai ka ua 'Isaaka. Eia naʻe, i loaa ia i ke kumu o ka pemphigus mea pilikia. Poe akamai i noho 'īnea nei me keia pilikia no na makahiki. Iloko o keia manawa ua waiho aku la lakou i kekahi kuhiakau.

• Exogenous aʻe, oa lawe lapaʻauʻia, me penicillin a me kona nā mea loaʻa, a me kela interferons a me nā mea a pau.
• Endogenous aʻe, me'ōnaehana paleʻea a me ka aaiaoe.
• Helu aʻe (e loli loaa nui'ā a me ka pāhawewe).
• Endocrine (e laʻa me hormonal ole i loko o kānaka).
• Nā mea hoʻomaʻi (Herpesviruses).
• E lawe i kekahi mauʻai.

Ma muli o kēia mau kumumea, ae wehewehe i ka paha hanana o ka maʻi, ke manao nei makou: pemphigus vulgaris hiki e immunological, endocrine, infectious, neurogenic,ʻawahia, etc. naʻe, ka mea e e kaulana ia he mea no na mea ike ole, ina e like me nā loli i iniiaiie paha e komo .. haumāna ano, ma muli o ke kumu kumu.

Ke'ī mai, ka mea hikiʻole, e kuhikuhi i ka kiko'ī kumu o ka noonoo autoimmune maʻi me ka nui loa hampers kona 'eleuʻike, no laila, he nui na kanaka pinepine hoʻomōhala complications nui.

nucleationʻano papa hana

Pehea o ka ulu ana o ia maʻi, e like me pemphigus? Photo ka loiloi mua ke kahua o ka maʻi, e hiki ke ike i loko o kēia 'atikala. Kilo'ōlelo aku nei au i ke kumu o ia pathologic autoaggressive kaʻina hana o ke kahua o nā mea'aʻaʻa i nā polokina pili ana i ka ohana o ka desmoglein. Ka hope ho i keʻano o ka "glue" e pili ana e pili epidermal keena Via kūikawā ai pili aku hehee wale, i ka poe i kaheaia desmosomes.

Once ho'ā 'lymphocytes a me autoantibodies hoouka mai i ka desmogleins, e kaawale epidermal keena mai kekahi i kekahi, a me ka epidermis lilo porous a me "Ke kekona'", malaila hoopuni ihi aku la, a malalo iho a hiki i ka anal o kekahi mau fungi a me koʻohune. Ma lapaʻau hana, ua kapaia acantholysis keia kŰia.

E like me ka hopena o ka luna kaʻina ka hoʻomanawanui i blisters ma luna o kaʻili, a pēlā hoʻi me kona mānoanoa. I ka Ia manawa ka mea, ua piha me ka exudate a mau fester. Over manawa, e ihi aku i nā Oe mai na a lahilahi,ʻilikai i ka'aʻaʻa, a ho okumu i pus, a mailoko o ulcers. I nui kou hihia, ua ho okumu i uhi kekahi i ka holoʻokoʻa ili o ke kino.

mōʻaukala 'ike

Mua he dermatological maʻi poe akamai i mai i ikeʻaneʻane iki. Kaʻia "pemphigus" pili i nā mea a pau lesions o mucous a me ka ili, ai ukali acantholysis, ho okumu ana o Oe a me ka poe o na a lahilahi a hiki i ke kūpono 'ana o ke suppurating na mai hehe. Naʻe, i ka 1964 i ka 'atikala i paʻiʻia i loko o ka' inikua puke, i loli i ka hoomaopopo ana o na kauka ma luna o ka maʻi ma ka nīnau, e like me kona kokoke i kaʻike, a me ka lapaau. Mai ia manawa, i ke alo o nā mea'aʻaʻa i loko o ke koko wai koko o nā mea maʻi e desmogleina lilo i ke kumu nui ana no ka 'ike o ke pemphigus.

Ma ke ala, i ka makahiki 1971, ua paʻi hou 'atikala ma i ka autoimmune ano o ka hoʻokolokolo ma au mamuli a me keʻano papa hana o ka? Acaeoey o keia maʻi.

Ka papa kuhikuhiE symptoms

Blisters ma kaʻili, mai ana ka ulu ana mai o konaʻena paha, he pono ole bladderwort, ho i ka hoailona mua o ka maʻi. It E e kaulana i kēiaʻano o ka maʻi ia lŘlŘ loa pinepine. E like me ka poe akamai, e hoike no ka 77% o nā mea a pau ia akulla 'ano o ka pemphigus.

Lesions i loko o ka palapala o Oe lakou aloha ole wale i ka ili o ka hoomanawanui, akā, i ka mucosa o ka waha a me kona puʻu. Ma hope ka mea, hohola mai ma luna o kekahi lala, mawaho wahine, maka, a no laila, ma luna o.

He aha oe e ike e pili ana i kēia mau ili mai? Nō kāu, pemphigus e hoʻomōhala ana i koke. Penei i ola ili mawaho hana liʻiliʻi Oe tensions i me ka appreciable māmā waiwai flaccid helehelena. Lākou mau Contents i ka aniani moakaka serous wai (iki turbid).

Ma hope o ka weheʻana i nā papules hanaia eroded luna, i a laila hoola, akā, e waiho i ko läkou 'o ka pigmentation o ka mea eleele.

No ka mea, he autoimmune maʻi wehewehe aku ma ka loa maʻi pele ma ka palapala. It E e kaulana ia i loko o kekahi kanaka me kekahi lapaau i malama noho'na makaainana i ulu hou ana, a i auou caiaiai ma ka aggravation.

Loa pinepine pu pemphigus vulgaris kiʻekiʻe nā mea palahēhē (candidiasis).

Aie i ka kumuʻiʻo poho, fluids a me infectious ole prognosis o keia maʻi me ka loa 'ano apau loa lakou malaila.

'Ike o ka maʻi

E like me ka weheia pemphigus vulgaris? ʻike, o ka mea maʻi ua lawe mai i loko o ka haukapila. Ke alo aku o ka maʻi ua 'akomi i ka nānā' ana ma luna o lapaʻau symptoms a me ka hopena o kālailai.

Ka mua nā:

• A symptom o asbestos-Hansen. Kēia hiʻona ua 'akomi i ka ua e kekahi manamanalima a ma luna o ka uhi aniani (a laila,ʻaʻole i komo iloko) Oe. Oia ke kaʻina hana no kōkua ai i nā poe o na epidermis i loko o ka wahi i mea e pili ana i papules, e like me mahuahua kona wahi ku ai i ka loli puʻe i loko o ka pa alima.
• Symptom Nikolsky. Kēia hiʻona ua 'akomi i loko o Oe entrainment na apana me forceps a anaanai i ka manamanalima hapa mawaho kōna ili kokoke i ka lesion paena. Pela ka mea, he poe no ka epidermis.

It E e hoʻomaopopo i ka poe pemphigus mau symptoms mea i kekahi, a me ka lapaʻau 'ana. Ua hoʻomanaʻoʻia ai ia i na hoike ana i hana i loko o nā maʻi.

keʻena hoʻokolohua ho'āʻo ma

Pehea ua diagnosed pemphigus vulgaris? Lapaʻau o autoimmune maʻi e halihaliia oia iwaho ma hope o ka 'inikua ninaninau wale. E huai ae ia i ka maʻi ua hoʻohana 'ia:

• Histological Ka Ikepili, pili i keia hookolokolo ana o smears, a me ka ai-kapaia fingerprint e hōʻike Oe acantholytic aeee ( 'o ia hoʻi, epidermal aeee mea i undergone morphological loli).

It E e kaulana ia ma ke kumu o histological Ka Ikepili o kaʻikepili e manao nei makou, o ka hooulu ana o autoimmune maʻi mea hiki ole. O ke kumu ho i ka mea i loaʻa i nā maʻi me ka like kiʻi.

• Immunofluorescence hana e huai ae intracellular hoʻokomo kālā o ka immunoglobulin G a me ka A, e like me ke kuhikuhi i nui a me ka nīnūnē antigens - desmoglein 3 a me ka desmoglein-1. Kēia papa hana o ka loa pololeiʻike.

Ke'ī mai, ai kaʻike, "ʻena pemphigus 'ua kau me ka nānā' ana i ka lōʻihi oʻikepili o ka lapaʻau symptoms a me ka lapaʻau kiʻi o ka mai, a me ka hopena o ka immunofluorescence 'ana i kūpono a me ka histologic ninaninau.

lapaʻau

I ka hoomaka ana o ka ulu o ka pemphigus vulgaris nā mea maʻi i hoakaka ia glucocorticoids. Ai 'ma keia pae i loaa ma ka hawewe nā māhele. Ke kauoha o ka lāʻau i loko o nui mea o ka nui o na hoike. Me ka pili ana i na contraindications a me kaʻaoʻao waiwai, ka mea, ua kiʻekiʻe.

He aha ina o ka maʻi ma ka ninau i hoakaka ia glucocorticoids? Hoomakaukau no ka iapaau ana o konaʻena puzyrchaki i e like penei: "Prednisolone" "Dexamethasone" a me ka "Triamptsinolon".

Once hou ana o ka hoomanawanui, a laila i loko o ka wa e kaawale aku o hou Oe, ua hoemiia ke kiʻekiʻe a me ka neʻe maila i ke kākoʻo i mea e pale aku recurrence ka mahele lāʻau o ka ai '. Oia lapaʻau o nā mea maʻi lōʻihi lawa.

Ma waho glucocorticoids, nā mea maʻi i hoʻokohu 'ia cytotoxic konohiki, immunosuppressants, a me "Methotrexate", "Azathioprine" a me "Prospidin". Ka mea, e pono ke wehe i na pilikia o adverse reactions ma hope o 'ai, inu ka walaʻauʻana ai'.

Other lapaʻau ki ina hana like

Inā loaʻa nō nāʻikepili i loko o autoimmune maʻi e hoomanawanui i hiki ke hana me antibiotics, a me ka ai 'e kākoʻo i ka mea'ōnaehana mānowai koko'ōnaehana, hooponopono ana i ke koko, a me normalize i ka functioning o ke akepaʻa a me nā puʻupaʻa.

I koiʻai ana o ka potasiuma-i loaʻa ka hope, kalipuna a me nā wikamina. No ka mea topical lapaʻau o pemphigus Anati-hoʻoʻino ai ', infusions a me decoctions o ka lau nahele hiki ke hoʻohana.

It E e kaulana no hoi ia, ke kaumaha ma muli o ka ano o ka hoʻomanawanui mea paha e häʻawi mai ai iä ia ke kaʻina hana like gemabsorbtsiya, transfusion o ke koko a me ka plasmapheresis.